Combining the ventilatory response to exercise and peak oxygen consumption is no better than peak oxygen consumption alone in predicting mortality in chronic heart failure.

Abstract:

BACKGROUND:A low peak oxygen uptake (pVO(2)) and steep VE/VCO(2) slope are independently associated with a worse prognosis in patients with chronic heart failure (CHF). We wished to confirm whether combining these variables as a ratio would lead to a more accurate predictor of prognosis than using either alone. METHODS:388 CHF patients completed a treadmill-based cardiopulmonary exercise test (CPET) to volitional exhaustion using a modified Bruce protocol. RESULTS:212 CHF patients completed the CPET with a peak RER >or= 1.0. Of these, 48 patients died and one was transplanted during follow-up. In surviving patients, the median follow-up period was 42 months (IQR 34-49 months). The ratio VE/VCO(2) slope/pVO(2) was calculated for each individual and its ability to predict outcome compared with other variables. The Cox multivariable survival analysis showed that pVO(2) was the strongest independent predictor of mortality in CHF patients. CONCLUSION:Our study shows that the composite variable VE/VCO(2) slope/pVO(2) is a less effective prognosticator than pVO(2) alone in patients with CHF.

journal_name

Eur J Heart Fail

authors

Ingle L,Witte KK,Cleland JG,Clark AL

doi

10.1016/j.ejheart.2007.10.010

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

85-8

issue

1

eissn

1388-9842

issn

1879-0844

pii

S1388-9842(07)00431-X

journal_volume

10

pub_type

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    authors: Damy T,Kallvikbacka-Bennett A,Zhang J,Goode K,Buga L,Hobkirk J,Yassin A,Dubois-Randé JL,Hittinger L,Cleland JG,Clark AL

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    pub_type: 杂志文章,多中心研究,随机对照试验

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    authors: Bouabdallaoui N,Claggett B,Zile MR,McMurray JJV,O'Meara E,Packer M,Prescott MF,Swedberg K,Solomon SD,Rouleau JL,PARADIGM-HF Investigators and Committees.

    更新日期:2018-12-01 00:00:00

  • Telemedical Interventional Monitoring in Heart Failure (TIM-HF), a randomized, controlled intervention trial investigating the impact of telemedicine on mortality in ambulatory patients with heart failure: study design.

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    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurjhf/hfq199

    authors: Koehler F,Winkler S,Schieber M,Sechtem U,Stangl K,Böhm M,Boll H,Kim SS,Koehler K,Lücke S,Honold M,Heinze P,Schweizer T,Braecklein M,Kirwan BA,Gelbrich G,Anker SD,TIM-HF Investigators.

    更新日期:2010-12-01 00:00:00

  • Desmin accumulation restrictive cardiomyopathy and atrioventricular block associated with desmin gene defects.

    abstract:BACKGROUND:Primary desminopathies are caused by desmin gene [DES (MIM*125660)] mutations. The clinical spectrum includes pure myopathies, cardiomuscular diseases and cardiomyopathies. Patients with restrictive cardiomyopathy (RCM) plus atrioventricular block (AVB) due to DES defects are frequently unrecognized unless d...

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    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2005.11.003

    authors: Arbustini E,Pasotti M,Pilotto A,Pellegrini C,Grasso M,Previtali S,Repetto A,Bellini O,Azan G,Scaffino M,Campana C,Piccolo G,Viganò M,Tavazzi L

    更新日期:2006-08-01 00:00:00