Characterization of health-related quality of life in heart failure patients with preserved versus low ejection fraction in CHARM.

Abstract:

BACKGROUND:Limited comparative studies assessing the health-related quality of life (HRQL) in heart failure (HF) patients with preserved vs. low ejection fraction (LVEF) have been disparate. AIMS:The aims of this study were a) to characterize HRQL in a large population of HF patients with preserved and low LVEF and b) to determine the factors associated with worse HRQL. METHODS:Patients with symptomatic HF (NYHA Class II-IV) enrolled in the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) HRQL study completed the Minnesota Living with Heart Failure questionnaire at randomization. Patients were stratified into 2 HF cohorts: preserved LVEF (>40%) and low LVEF (

journal_name

Eur J Heart Fail

authors

Lewis EF,Lamas GA,O'Meara E,Granger CB,Dunlap ME,McKelvie RS,Probstfield JL,Young JB,Michelson EL,Halling K,Carlsson J,Olofsson B,McMurray JJ,Yusuf S,Swedberg K,Pfeffer MA,CHARM Investigators.

doi

10.1016/j.ejheart.2006.10.012

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

83-91

issue

1

eissn

1388-9842

issn

1879-0844

pii

S1388-9842(06)00339-4

journal_volume

9

pub_type

杂志文章,多中心研究
  • Predictors and prognostic impact of recurrent myocardial infarction in patients with left ventricular dysfunction, heart failure, or both following a first myocardial infarction.

    abstract:UNLABELLED:IMS: Recurrent myocardial infarction (MI) is common after a first MI and is associated with increased morbidity and mortality. Predictors and prognosis of a recurrent MI with contemporary management are not well known. METHODS AND RESULTS:We assessed the predictors and prognostic impact of a first recurrent...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurjhf/hfq194

    authors: Thune JJ,Signorovitch JE,Kober L,McMurray JJ,Swedberg K,Rouleau J,Maggioni A,Velazquez E,Califf R,Pfeffer MA,Solomon SD

    更新日期:2011-02-01 00:00:00

  • The increase in serum uric acid concentration caused by diuretics might be beneficial in heart failure.

    abstract::Patients with mild-moderate chronic heart failure (CHF) often have raised levels of serum uric acid (UA). This is due, amongst other factors, to reduced UA excretion by the kidneys, which is partly explained by restriction of sodium intake and treatment with diuretics. The decline in renal function that parallels wors...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejheart.2004.03.020

    authors: Reyes AJ

    更新日期:2005-06-01 00:00:00

  • Optimized Implementation of cardiac resynchronization therapy - a call for action for referral and optimization of care.

    abstract::Cardiac resynchronization therapy (CRT) is one of the most effective therapies for heart failure with reduced ejection fraction and leads to improved quality of life, reductions in heart failure hospitalization rates and reduces all-cause mortality. Nevertheless, up to two-thirds of eligible patients are not referred ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.2046

    authors: Mullens W,Auricchio A,Martens P,Witte K,Cowie MR,Delgado V,Dickstein K,Linde C,Vernooy K,Leyva F,Bauersachs J,Israel CW,Lund L,Donal E,Boriani G,Jaarsma T,Berruezo A,Traykov V,Yousef Z,Kalarus Z,Nielsen JC,Steff

    更新日期:2020-11-02 00:00:00

  • Circulating proteins as predictors of incident heart failure in the elderly.

    abstract:AIMS:To identify novel risk markers for incident heart failure using proteomic profiling of 80 proteins previously associated with cardiovascular pathology. METHODS AND RESULTS:Proteomic profiling (proximity extension assay) was performed in two community-based prospective cohorts of elderly individuals without heart ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ejhf.980

    authors: Stenemo M,Nowak C,Byberg L,Sundström J,Giedraitis V,Lind L,Ingelsson E,Fall T,Ärnlöv J

    更新日期:2018-01-01 00:00:00

  • The use of diuretics in heart failure with congestion - a position statement from the Heart Failure Association of the European Society of Cardiology.

    abstract::The vast majority of acute heart failure episodes are characterized by increasing symptoms and signs of congestion with volume overload. The goal of therapy in those patients is the relief of congestion through achieving a state of euvolaemia, mainly through the use of diuretic therapy. The appropriate use of diuretic...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1002/ejhf.1369

    authors: Mullens W,Damman K,Harjola VP,Mebazaa A,Brunner-La Rocca HP,Martens P,Testani JM,Tang WHW,Orso F,Rossignol P,Metra M,Filippatos G,Seferovic PM,Ruschitzka F,Coats AJ

    更新日期:2019-02-01 00:00:00

  • Update of ELITE-II, BEST, CHAMP, and IMPRESS clinical trials in heart failure.

    abstract::The ELITE-II, BEST and CHAMP Trials were reported for the first time at the American Heart Association in November 1999. These trials provide valuable new information to guide clinical practice in the management of heart failure and of myocardial infarction, although none mandate a major change from current clinical p...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(00)00053-2

    authors: Witte K,Thackray S,Banerjee T,Clark AL,Cleland JG

    更新日期:2000-03-01 00:00:00

  • The prognostic significance of heart failure with preserved left ventricular ejection fraction: a literature-based meta-analysis.

    abstract:AIMS:Heart failure (HF) with normal or preserved left ventricular (LV) ejection fraction (HFPEF) has been reported to be associated with similar outcome as HF with reduced EF (HFREF) in registry-based and epidemiological analyses, but many of these studies excluded patients who did not have EF measurements. Conversely,...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,meta分析

    doi:10.1093/eurjhf/hfp103

    authors: Somaratne JB,Berry C,McMurray JJ,Poppe KK,Doughty RN,Whalley GA

    更新日期:2009-09-01 00:00:00

  • Home telemonitoring in heart failure patients: the HHH study (Home or Hospital in Heart Failure).

    abstract:AIMS:The Home or Hospital in Heart failure (HHH) study was a European Community-funded, multinational, randomized controlled clinical trial, conducted in the UK, Poland, and Italy, to assess the feasibility of a new system of home telemonitoring (HT). The HT system was used to monitor clinical and physiological paramet...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurjhf/hfp022

    authors: Mortara A,Pinna GD,Johnson P,Maestri R,Capomolla S,La Rovere MT,Ponikowski P,Tavazzi L,Sleight P,HHH Investigators.

    更新日期:2009-03-01 00:00:00

  • Heart failure and chronic obstructive pulmonary disease: diagnostic pitfalls and epidemiology.

    abstract::Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are global epidemics incurring significant morbidity and mortality. The combination presents many diagnostic challenges. Clinical symptoms and signs frequently overlap. Evaluation of cardiac and pulmonary function is often problematic and occasionally...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1093/eurjhf/hfn013

    authors: Hawkins NM,Petrie MC,Jhund PS,Chalmers GW,Dunn FG,McMurray JJ

    更新日期:2009-02-01 00:00:00

  • Are the effects of drugs to prevent and to treat heart failure always concordant? The statin paradox and its implications for understanding the actions of antidiabetic medications.

    abstract::Most treatments for chronic heart failure are effective both in preventing its onset and reducing its progression. However, statins prevent the development of heart failure, but they do not decrease morbidity and mortality in those with established heart failure. This apparent discordance cannot be explained by an eff...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1002/ejhf.1183

    authors: Packer M

    更新日期:2018-07-01 00:00:00

  • Left ventricular SERCA2a gene down-regulation does not parallel ANP gene up-regulation during post-MI remodelling in rats.

    abstract:BACKGROUND:In most animal models of chronic hemodynamic overload of the left ventricle (LV) as well as in human end stage heart failure, the sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA2a) mRNA levels are decreased in parallel with increased atrial natriuretic peptide (ANP) mRNA levels. The situation in the remote my...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2004.10.007

    authors: Prunier F,Chen Y,Gellen B,Heimburger M,Choqueux C,Escoubet B,Michel JB,Mercadier JJ

    更新日期:2005-08-01 00:00:00

  • Improvement but no cure of left ventricular systolic dysfunction in treated heart failure patients.

    abstract:BACKGROUND:Recent advances in pharmacological and pacemaker-based treatments for heart failure (HF) have brought about significant improvements in left ventricular function. AIMS:To identify the proportion of treated systolic HF patients in whom left ventricular systolic function improves and/or returns to normal. ME...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2007.10.001

    authors: Murphy NF,O'Loughlin C,Ledwidge M,McCaffrey D,McDonald K

    更新日期:2007-12-01 00:00:00

  • Prevalence and prognostic significance of atrial fibrillation in outpatients with heart failure due to left ventricular systolic dysfunction.

    abstract:INTRODUCTION:Atrial fibrillation (AF) is common in patients with heart failure (HF) due to left ventricular systolic dysfunction (LVSD), with conflicting prognostic data. The aim of our study was to assess the prevalence and incidence of AF in patients with HF and to determine the prognostic impact of baseline AF and t...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ejheart.2006.08.004

    authors: Corell P,Gustafsson F,Schou M,Markenvard J,Nielsen T,Hildebrandt P

    更新日期:2007-03-01 00:00:00

  • Heart failure prognosis over time: how the prognostic role of oxygen consumption and ventilatory efficiency during exercise has changed in the last 20 years.

    abstract:AIMS:Exercise-derived parameters, specifically peak exercise oxygen uptake (peak VO2 ) and minute ventilation/carbon dioxide relationship slope (VE/VCO2 slope), have a pivotal prognostic value in heart failure (HF). It is unknown how the prognostic threshold of peak VO2 and VE/VCO2 slope has changed over the last 20 ye...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ejhf.1364

    authors: Paolillo S,Veglia F,Salvioni E,Corrà U,Piepoli M,Lagioia R,Limongelli G,Sinagra G,Cattadori G,Scardovi AB,Metra M,Senni M,Bonomi A,Scrutinio D,Raimondo R,Emdin M,Magrì D,Parati G,Re F,Cicoira M,Minà C,Correale M

    更新日期:2019-02-01 00:00:00

  • High intracellular Na+ preserves myocardial function at low heart rates in isolated myocardium from failing hearts.

    abstract::We investigated the hypothesis that increased intracellular [Na+]i in heart failure contributes to preservation of SR Ca2+ load which may become particularly evident at slow heart rates. [Na+]i in SBFI-loaded myocytes from rabbits with pacing-induced heart failure (PHF) was significantly higher at each frequency as co...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2006.01.013

    authors: Schillinger W,Teucher N,Christians C,Kohlhaas M,Sossalla S,Van Nguyen P,Schmidt AG,Schunck O,Nebendahl K,Maier LS,Zeitz O,Hasenfuss G

    更新日期:2006-11-01 00:00:00

  • Cardiomyocyte-restricted over-expression of C-type natriuretic peptide prevents cardiac hypertrophy induced by myocardial infarction in mice.

    abstract:OBJECTIVE:Infused C-type natriuretic peptide (CNP) was recently found to play a cardioprotective role in preventing myocardial ischaemia/reperfusion (I/R) injury and improving cardiac remodelling after myocardial infarction (MI) in rats. Our study aimed to investigate the effect of cardiomyocyte-specific CNP over-expre...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2007.02.006

    authors: Wang Y,de Waard MC,Sterner-Kock A,Stepan H,Schultheiss HP,Duncker DJ,Walther T

    更新日期:2007-06-01 00:00:00

  • The role of correction of anaemia in patients with congestive heart failure: a short review.

    abstract::Many patients with Congestive Heart Failure (CHF) are anaemic. This anaemia is associated with more severe CHF and a higher incidence of mortality, hospitalisation and morbidity. The only way to prove that the anaemia is causing this worsening of CHF is to correct it. We review here some of the published papers about ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejheart.2008.06.015

    authors: Silverberg DS,Wexler D,Iaina A,Schwartz D

    更新日期:2008-09-01 00:00:00

  • Long-term effectiveness of the combined minute ventilation and patient activity sensors as predictor of heart failure events in patients treated with cardiac resynchronization therapy: Results of the Clinical Evaluation of the Physiological Diagnosis Func

    abstract:AIMS:Monitoring early signs of clinical deterioration could allow physicians to adjust medical treatment for patients at risk of acute heart failure decompensation. To date, several strategies using different surrogate measures of clinical status emerged, but none has yet been proven to predict clinical events. We hypo...

    journal_title:European journal of heart failure

    pub_type: 临床试验,杂志文章

    doi:10.1002/ejhf.79

    authors: Auricchio A,Gold MR,Brugada J,Nölker G,Arunasalam S,Leclercq C,Defaye P,Calò L,Baumann O,Leyva F

    更新日期:2014-06-01 00:00:00

  • Oral sucrosomial iron improves exercise capacity and quality of life in heart failure with reduced ejection fraction and iron deficiency: a non-randomized, open-label, proof-of-concept study.

    abstract:AIMS:Oral sucrosomial iron (SI) combines enhanced bioavailability and tolerance compared to conventional oral iron along with similar efficacy compared to intravenous iron in several conditions associated with iron deficiency (ID). METHODS AND RESULTS:In this non-randomized, open-label study, we sought to evaluate pro...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.2092

    authors: Karavidas A,Troganis E,Lazaros G,Balta D,Karavidas IN,Polyzogopoulou E,Parissis J,Farmakis D

    更新日期:2021-01-09 00:00:00

  • Nutritional status in tricuspid regurgitation: implications of transcatheter repair.

    abstract:AIMS:To characterize the prevalence and clinical relevance of malnutrition in patients undergoing transcatheter tricuspid valve edge-to-edge repair (TTVR). METHODS AND RESULTS:Overall, 86 consecutive patients (mean age 78 ± 7 years) with moderate-to-severe tricuspid regurgitation (TR) at prohibitive surgical risk were...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.1752

    authors: Besler C,Unterhuber M,Rommel KP,Unger E,Hartung P,von Roeder M,Noack T,Zachäus M,Halm U,Borger M,Desch S,Thiele H,Lurz P

    更新日期:2020-10-01 00:00:00

  • A functional variant of the neuropeptide S receptor-1 gene modulates clinical outcomes and healthcare utilization in patients with systolic heart failure: results from the Interdisciplinary Network Heart Failure (INH) Study.

    abstract:AIMS:Psychopathologies may occur in heart failure (HF) and can be associated with adverse outcomes. Amongst neuropeptide S receptor gene functional sequence variants, the T-allele [asparagine(107)isoleucine, NPSR1 rs324981] has been identified as a risk factor for increased anxiety/overinterpretation of bodily symptoms...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.706

    authors: Angermann CE,Kaspar M,Marx A,Kittel-Schneider S,Menhofer D,Störk S,Ertl G,Domschke K,Deckert J,Reif A

    更新日期:2017-03-01 00:00:00

  • Baseline characteristics and outcomes of patients with heart failure receiving bronchodilators in the CHARM programme.

    abstract:AIMS:Heart failure (HF) and chronic obstructive pulmonary disease are common partners. Bronchodilators are associated with adverse cardiovascular outcomes in patients with pulmonary disease. The outcome of patients with HF prescribed bronchodilators is poorly defined. METHODS AND RESULTS:The Candesartan in Heart failu...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurjhf/hfq040

    authors: Hawkins NM,Wang D,Petrie MC,Pfeffer MA,Swedberg K,Granger CB,Yusuf S,Solomon SD,Ostergren J,Michelson EL,Pocock SJ,Maggioni AP,McMurray JJ,CHARM Investigators and Committees.

    更新日期:2010-06-01 00:00:00

  • Mitral annular plane systolic excursion on exercise: a simple diagnostic tool for heart failure with preserved ejection fraction.

    abstract:AIMS:Current guidelines for the diagnosis of heart failure with normal or preserved ejection fraction (HFpEF) are based on measurements at rest. However, in HFpEF ventricular dysfunction is more apparent on exercise. We hypothesized that Mitral annular plane systolic excursion (MAPSE) which is easy to acquire on exerci...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfr081

    authors: Wenzelburger FW,Tan YT,Choudhary FJ,Lee ES,Leyva F,Sanderson JE

    更新日期:2011-09-01 00:00:00

  • Diabetes mellitus and cardiogenic shock in acute myocardial infarction.

    abstract:AIMS:Cardiogenic shock is the leading cause of in-hospital mortality after acute myocardial infarction (MI). This study investigates the importance of age and preexisting diabetes mellitus on the incidence and prognosis of cardiogenic shock in a large group of consecutive patients with MI. METHODS AND RESULTS:Baseline...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2004.09.007

    authors: Lindholm MG,Boesgaard S,Torp-Pedersen C,Køber L,TRACE registry study group.

    更新日期:2005-08-01 00:00:00

  • Corrigendum to 'What does the lay public know about heart failure? Findings from the Heart Failure Awareness Day Initiative'[Eur J Heart Fail 2016; 18:66-70].

    abstract::The published version of this paper contained an error. The part C of the figure only has the header "multiple organs", whereas it must read: “HF does not affect multiple organs”. ...

    journal_title:European journal of heart failure

    pub_type: 已发布勘误

    doi:10.1002/ejhf.499

    authors:

    更新日期:2016-02-01 00:00:00

  • Pilot assessment of the response of several pulmonary hemodynamic variables to sublingual sildenafil in candidates for heart transplantation.

    abstract:OBJECTIVE:To determine the acute vasodilator effect of sublingual sildenafil in heart transplant candidates with severe pulmonary hypertension due to severe left ventricular dysfunction (LVD). BACKGROUND:Pulmonary hypertension confers an increased risk of early graft failure. PATIENTS AND METHODS:Seven patients, (mea...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2003.11.015

    authors: Angel Gómez-Sánchez M,Saenz De La Calzada C,Escribano Subías P,Francisco Delgado Jiménez J,Lázaro Salvador M,Albarrán González A,Cea Calvo L

    更新日期:2004-08-01 00:00:00

  • Heart failure with normal ejection fraction is uncommon in acute myocardial infarction settings but associated with poor outcomes: a study of 91,360 patients admitted with index myocardial infarction between 1998 and 2010.

    abstract:AIM:Data are scant on the incidence and prognosis of heart failure (HF) with normal ejection fraction (HFNEF, EF >49%) in an acute myocardial infarction (AMI) setting. The aim of this study was to examine incidence and predictors of HFNEF during an index acute myocardial infarction (AMI) and its subsequent associations...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.416

    authors: Desta L,Jernberg T,Spaak J,Hofman-Bang C,Persson H

    更新日期:2016-01-01 00:00:00

  • Frequent non-cardiac comorbidities in patients with chronic heart failure.

    abstract::Heart failure (HF) in elderly patients is associated with more diffuse symptoms and signs due to the presence of other noncardiac comorbidities. This can cause difficulties in assessing the correct diagnosis and initiating appropriate therapy. The four most frequently occurring noncardiac comorbidities and therapies u...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejheart.2005.01.008

    authors: Dahlström U

    更新日期:2005-03-16 00:00:00

  • Prognostic importance of cognitive impairment in chronic heart failure patients: does specialist management make a difference?

    abstract:BACKGROUND:Cognitive impairment is common among chronic heart failure (CHF) patients. AIMS:To determine the prognostic significance of cognitive impairment in patients participating in a randomized study of a CHF management program (CHF-MP). METHODS:CHF patients were randomized to a CHF-MP (n=100) or usual care (n=10...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2005.11.013

    authors: McLennan SN,Pearson SA,Cameron J,Stewart S

    更新日期:2006-08-01 00:00:00

  • Effects of diuretic treatment on cardiac and circulating RAS in chronic heart failure post-myocardial infarction in rats.

    abstract:BACKGROUND:Cardiac angiotensin converting enzyme (ACE) is activated by an increase in wall stress and is involved in remodeling processes. Heart failure is often treated with ACE inhibitors and diuretics although diuretic treatment could activate the renin-angiotensin system (RAS). AIMS:To examine the effects of diure...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(02)00242-8

    authors: Seeland U,Kouchi I,Zolk O,Jockenhövel F,Itter G,Linz W,Böhm M

    更新日期:2003-06-01 00:00:00