Update of ELITE-II, BEST, CHAMP, and IMPRESS clinical trials in heart failure.

abstract：BACKGROUND:Knowledge on clinical characteristics and prognosis of patients with heart failure originates from studies of selected populations in clinical trials or from epidemiological observations. Reports on the large numbers of patients with heart failure treated in community hospitals are sparse. OBJECTIVE:Are the...

journal_title：European journal of heart failure

authors： Taubert G,Bergmeier C,Andresen H,Senges J,Potratz J

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:The angiotensin II type 2 (AT2) receptor is thought to play a role in cardiovascular disorders such as neointima formation after vascular injury, cardiac hypertrophy and myocardial infarction (MI). Recently, the biallelic polymorphism G + 1675A in intron 1 of the AT2 receptor gene has been associated with le...

journal_title：European journal of heart failure

authors： Herrmann SM,Nicaud V,Schmidt-Petersen K,Pfeifer J,Erdmann J,McDonagh T,Dargie HJ,Paul M,Regitz-Zagrosek V

更新日期：2002-12-01 00:00:00

abstract：AIMS:Randomized trials have shown that beta-blockers (BBs) reduce mortality in chronic heart failure (HF). Less data are available on the role of BBs in patients with acute HF, specifically if BBs should be continued or temporarily withdrawn. The aim of this study was to evaluate the role of BBs on in-hospital outcomes...

journal_title：European journal of heart failure

authors： Orso F,Baldasseroni S,Fabbri G,Gonzini L,Lucci D,D'Ambrosi C,Gobbi M,Lecchi G,Randazzo S,Masotti G,Tavazzi L,Maggioni AP,Italian Survey on Acute Heart Failure Investigators.

更新日期：2009-01-01 00:00:00

abstract：AIMS:Psychopathologies may occur in heart failure (HF) and can be associated with adverse outcomes. Amongst neuropeptide S receptor gene functional sequence variants, the T-allele [asparagine(107)isoleucine, NPSR1 rs324981] has been identified as a risk factor for increased anxiety/overinterpretation of bodily symptoms...

journal_title：European journal of heart failure

authors： Angermann CE,Kaspar M,Marx A,Kittel-Schneider S,Menhofer D,Störk S,Ertl G,Domschke K,Deckert J,Reif A

更新日期：2017-03-01 00:00:00

abstract：AIMS:To identify novel risk markers for incident heart failure using proteomic profiling of 80 proteins previously associated with cardiovascular pathology. METHODS AND RESULTS:Proteomic profiling (proximity extension assay) was performed in two community-based prospective cohorts of elderly individuals without heart ...

journal_title：European journal of heart failure

authors： Stenemo M,Nowak C,Byberg L,Sundström J,Giedraitis V,Lind L,Ingelsson E,Fall T,Ärnlöv J

更新日期：2018-01-01 00:00:00

abstract：AIMS:To investigate the annual hospitalization rate and seasonal variation in confirmed heart failure (HF) admissions. METHODS AND RESULTS:Records from all admissions to one hospital during 1 year with a HF diagnostic code were reviewed. From 1953 admissions, 595 were excluded because they did not fulfill the diagnost...

journal_title：European journal of heart failure

authors： Martínez-Sellés M,García Robles JA,Prieto L,Serrano JA,Muñoz R,Frades E,Almendral J

更新日期：2002-12-01 00:00:00

abstract：:It is well known that atrial fibrillation can lead to heart failure, and is attributed to rapid ventricular rate (tachycardia-induced cardiomyopathy). Some recent studies suggest the possible existence of an intrinsic left-ventricular factor related to atrial fibrillation, irrespective of other elements. In order to d...

journal_title：European journal of heart failure

authors： Jourdain P,Bellorini M,Funck F,Fulla Y,Guillard N,Loiret J,Thebault B,Sadeg N,Desnos M

更新日期：2002-06-01 00:00:00

abstract：AIMS:Women are more likely to develop heart failure with preserved ejection fraction (HFpEF) than men. We studied the relationship between sex and cardiovascular structure and function in patients with HFpEF. METHODS AND RESULTS:The study included 279 participants from the PARAMOUNT study (57% women) with analysable b...

journal_title：European journal of heart failure

authors： Gori M,Lam CS,Gupta DK,Santos AB,Cheng S,Shah AM,Claggett B,Zile MR,Kraigher-Krainer E,Pieske B,Voors AA,Packer M,Bransford T,Lefkowitz M,McMurray JJ,Solomon SD,PARAMOUNT Investigators.

更新日期：2014-05-01 00:00:00

abstract：AIMS:Chronic heart failure (CHF) is associated with a higher risk for diabetes mellitus. Retinol binding protein 4 (RBP 4) is an adipose tissue-derived protein with pro-diabetogenic effects. A complete understanding of the association of CHF and insulin resistance remains elusive. The purpose of this study was to exami...

journal_title：European journal of heart failure

authors： Bobbert P,Weithäuser A,Andres J,Bobbert T,Kühl U,Schultheiss HP,Rauch U,Skurk C

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Crataegus preparations have been used for centuries especially in Europe. To date, no proper data on their efficacy and safety as an add-on-treatment are available. Therefore a large morbidity/mortality trial was performed. AIM:To investigate the efficacy and safety of an add-on treatment with Crataegus ext...

journal_title：European journal of heart failure

authors： Holubarsch CJ,Colucci WS,Meinertz T,Gaus W,Tendera M,Survival and Prognosis: Investigation of Crataegus Extract WS 1442 in CHF (SPICE) trial study group.

更新日期：2008-12-01 00:00:00

abstract：:Dilated cardiomyopathy (DCM) represents a particular aetiology of systolic heart failure that frequently has a genetic background and usually affects young patients with few co-morbidities. The prognosis of DCM has improved substantially during the last decades due to more accurate aetiological characterization, the r...

journal_title：European journal of heart failure

authors： Merlo M,Cannatà A,Gobbo M,Stolfo D,Elliott PM,Sinagra G

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Platelet-endothelial interactions modulated by adhesion molecules, may play an important role in the pathogenesis of congestive heart failure (CHF). Soluble levels of these molecules and platelet-derived substances are reportedly elevated in patients with CHF. However, no data are available on the plasma lev...

journal_title：European journal of heart failure

authors： Serebruany VL,Murugesan SR,Pothula A,Atar D,Lowry DR,O'Connor CM,Gurbel PA

更新日期：1999-08-01 00:00:00

abstract：:The use of erythropoietin (EPO) has revolutionized the treatment of anaemia associated with many conditions including chronic kidney disease (CKD). However, little is known of the cellular impact of EPO on the uraemic heart. The discovery that the EPO receptor (EPOR) is also expressed on non-haematopoietic cells inclu...

journal_title：European journal of heart failure

authors： Smith K,Semple D,Bhandari S,Seymour AM

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:The use of oral anticoagulation in patients with heart failure in sinus rhythm remains controversial as previous large randomized controlled trials (RCTs) have not shown a survival benefit. However, heterogeneity exists among heart failure patients and it is possible that high-risk subgroups may benefit from...

journal_title：European journal of heart failure

authors： Goudie A,Elder D,Deshmukh H,Szwejkowski BR,Lang CC,George J

更新日期：2015-01-01 00:00:00

abstract：:Although no universal definition exists, decompensated heart failure may be regarded as either a worsening of chronic heart failure or new-onset heart failure precipitated by an acute incident. Haemodynamic management of patients hospitalised with decompensated heart failure may include the administration of diuretics...

journal_title：European journal of heart failure

authors： Greenberg B,Borghi C,Perrone S

更新日期：2003-01-01 00:00:00

abstract：AIMS:Severe heart failure (HF) is often associated with cachexia that reverses post-heart transplantation (HTx) with frequent development of obesity. Ghrelin is a novel appetite-stimulating hormone. The aim was to determine the role of ghrelin in regulating appetite, food intake, and body composition in HF and post-HTx...

journal_title：European journal of heart failure

authors： Lund LH,Williams JJ,Freda P,LaManca JJ,LeJemtel TH,Mancini DM

更新日期：2009-08-01 00:00:00

abstract：AIMS:The proteasome prevents the intracellular accumulation of proteins and its impairment can lead to structural and functional alterations, as noted for the coronary vasculature in a previous study. Utilizing the same model, this study was designed to test the hypothesis that chronic proteasome inhibition (PSI) also ...

journal_title：European journal of heart failure

authors： Herrmann J,Wohlert C,Saguner AM,Flores A,Nesbitt LL,Chade A,Lerman LO,Lerman A

更新日期：2013-06-01 00:00:00

abstract：AIMS:To investigate the prevalence of iron deficiency (ID) in heart failure (HF) patients with normal vs. abnormal red cell indices (RCI), the associations between iron parameters and RCI, and prognostic consequences of ID independently of RCI. METHODS AND RESULTS:We analysed clinical data of 1821 patients with HF [me...

journal_title：European journal of heart failure

authors： Tkaczyszyn M,Comín-Colet J,Voors AA,van Veldhuisen DJ,Enjuanes C,Moliner-Borja P,Rozentryt P,Poloński L,Banasiak W,Ponikowski P,van der Meer P,Jankowska EA

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:In acute heart failure syndromes (AHFS), the prognostic value of left ventricular ejection fraction (LVEF), although widely accepted, has been recently challenged. In contrast, blood pressure is increasingly gaining ground over LVEF as predictor of mortality. Therefore, it is not clear whether both LVEF and ...

journal_title：European journal of heart failure

authors： Adamopoulos C,Zannad F,Fay R,Mebazaa A,Cohen-Solal A,Guize L,Juillière Y,Alla F

更新日期：2007-09-01 00:00:00

abstract：AIMS:The MITRA-FR trial showed that among symptomatic patients with severe secondary mitral regurgitation, percutaneous repair did not reduce the risk of death or hospitalization for heart failure at 12 months compared with guideline-directed medical treatment alone. We report the 24-month outcome from this trial. MET...

journal_title：European journal of heart failure

authors： Iung B,Armoiry X,Vahanian A,Boutitie F,Mewton N,Trochu JN,Lefèvre T,Messika-Zeitoun D,Guerin P,Cormier B,Brochet E,Thibault H,Himbert D,Thivolet S,Leurent G,Bonnet G,Donal E,Piriou N,Piot C,Habib G,Rouleau F,Car

更新日期：2019-12-01 00:00:00

abstract：AIMS:Urine proteome analysis (UPA) has already provided accurate discriminatory patterns of urinary peptides for renal disease, coronary artery disease, and asymptomatic LV diastolic dysfunction. UPA has now been used to characterize a discriminatory peptide biomarker pattern and establish a diagnostic classifier for h...

journal_title：European journal of heart failure

authors： Farmakis D,Koeck T,Mullen W,Parissis J,Gogas BD,Nikolaou M,Lekakis J,Mischak H,Filippatos G

更新日期：2016-07-01 00:00:00

abstract：AIMS:The identification of valuable markers of sudden cardiac death (SCD) in patients with established HF remains a challenge. We sought to assess the value of clinical, echocardiographic and biochemical variables to predict SCD in a consecutive cohort of patients with heart failure (HF) due to systolic dysfunction. M...

journal_title：European journal of heart failure

authors： Bayes-Genis A,Vazquez R,Puig T,Fernandez-Palomeque C,Fabregat J,Bardají A,Pascual-Figal D,Ordoñez-Llanos J,Valdes M,Gabarrús A,Pavon R,Pastor L,Gonzalez Juanatey JR,Almendral J,Fiol M,Nieto V,Macaya C,Cinca J,Bayes de

更新日期：2007-08-01 00:00:00

abstract：:Heart failure and sleep apnoea are major health problems with an increasingly recognized association; evidence suggests that sleep apnoea may play a role in the progression of heart failure. However, confounding factors such as obesity, hypertension and coronary heart disease make this relationship uncertain and an in...

journal_title：European journal of heart failure

authors： Ferreira S,Winck J,Bettencourt P,Rocha-Goncalves F

更新日期：2006-05-01 00:00:00

abstract：AIMS:To examine the impact of diabetes mellitus on long-term clinical outcomes in patients with myocardial infarction (MI) complicated by clinical signs of heart failure (HF) or left ventricular dysfunction (LVD). METHODS AND RESULTS:The High-Risk MI Database consists of individual data from 28 771 patients and was cr...

journal_title：European journal of heart failure

authors： Tajik AA,Dobre D,Aguilar D,Kjekshus J,Zannad F,Dickstein K,High-Risk MI Database Scientific Committee.

更新日期：2017-05-01 00:00:00

abstract：AIMS:Heart failure (HF) patients with a mid-range ejection fraction (HFmrEF) are not well characterized. Accordingly, we examined the epidemiology, pathophysiology and clinical outcomes of HF patients with a left ventricular ejection fraction (LVEF) of 40-50%. METHODS AND RESULTS:We identified 168 patients with an LVE...

journal_title：European journal of heart failure

authors： Rastogi A,Novak E,Platts AE,Mann DL

更新日期：2017-12-01 00:00:00

abstract：AIMS:The prognostic value of signs of congestion in patients suspected of having chronic heart failure (CHF) is unknown. Our objectives were to define their prevalence and specificity in diagnosing CHF and to determine their prognostic value in patients in a community heart failure clinic. METHODS AND RESULTS:Analysis...

journal_title：European journal of heart failure

authors： Damy T,Kallvikbacka-Bennett A,Zhang J,Goode K,Buga L,Hobkirk J,Yassin A,Dubois-Randé JL,Hittinger L,Cleland JG,Clark AL

更新日期：2011-12-01 00:00:00

abstract：AIMS:To evaluate in patients with heart failure (HF) due to systolic dysfunction the occurrence of polypharmacy, alternative medicine, immunization against influenza, and patients' knowledge about their medication. METHODS AND RESULTS:Sixty-five patients, 49 men, mean age 60.5+/-12.0 years answered a confidential ques...

journal_title：European journal of heart failure

authors： Martínez-Sellés M,García Robles JA,Muñoz R,Serrano JA,Frades E,Domínguez Muñoa M,Almendral J

更新日期：2004-03-01 00:00:00

abstract：AIMS:To determine whether a strategy of intensive blood pressure control reduces the risk of heart failure (HF) events consistently across the spectrum of kidney function and albuminuria. METHODS AND RESULTS:SPRINT was a randomized clinical trial in which 9361 individuals ≥50 years, at high risk for or with cardiovasc...

journal_title：European journal of heart failure

authors： Vaduganathan M,Pareek M,Kristensen AMD,Biering-Sørensen T,Byrne C,Almarzooq Z,Olesen TB,Olsen MH,Bhatt DL

更新日期：2020-07-21 00:00:00

abstract：AIMS:Although pulse pressure (PP) is a recognized risk factor for various cardiovascular diseases, its association with cardiovascular outcomes in patients with heart failure with preserved ejection fraction (HFpEF) is uncertain. METHODS AND RESULTS:We enrolled 512 of 951 consecutive HFpEF patients admitted to the Kum...

journal_title：European journal of heart failure

authors： Tokitsu T,Yamamoto E,Hirata Y,Kusaka H,Fujisue K,Sueta D,Sugamura K,Sakamoto K,Tsujita K,Kaikita K,Hokimoto S,Sugiyama S,Ogawa H

更新日期：2016-11-01 00:00:00

abstract：AIMS:Remote patient management (telemonitoring) may help to detect early signs of cardiac decompensation, allowing optimization of and adherence to treatments in chronic heart failure (CHF). Two meta-analyses have suggested that telemedicine in CHF can reduce mortality by 30-35%. The aim of the TIM-HF study was to inve...

journal_title：European journal of heart failure

authors： Koehler F,Winkler S,Schieber M,Sechtem U,Stangl K,Böhm M,Boll H,Kim SS,Koehler K,Lücke S,Honold M,Heinze P,Schweizer T,Braecklein M,Kirwan BA,Gelbrich G,Anker SD,TIM-HF Investigators.

更新日期：2010-12-01 00:00:00