Abstract:
AIMS:Although pulse pressure (PP) is a recognized risk factor for various cardiovascular diseases, its association with cardiovascular outcomes in patients with heart failure with preserved ejection fraction (HFpEF) is uncertain. METHODS AND RESULTS:We enrolled 512 of 951 consecutive HFpEF patients admitted to the Kumamoto University Hospital between 2007 and 2013 and divided them into five groups according to PP quintiles. Blood pressure and pulse wave velocity (PWV) were measured by an ankle-brachial index device. The PP values in HFpEF were significantly and positively correlated with PWV and LV stroke volume index, and were negatively correlated with estimated glomerular filtration rate and haemoglobin levels. Furthermore, plasma B-type natriuretic peptide levels in HFpEF patients with the lowest (<45 mmHg) and highest PP (≥75 mmHg) were significantly higher than those with other PP (45-74 mmHg). The percentage of total cardiovascular and heart failure (HF)-related events by PP category resulted in U- and J-shaped curves. The higher frequency of coronary-related events was nearly linear. In the Kaplan-Meier analysis, HFpEF patients with the lowest and highest PP quintiles had a significantly higher risk of cardiovascular and HF-related events than those with other PPs (45-74 mmHg) (log-rank test, both P < 0.01). Conversely, the frequency of coronary-related events in the highest PP group, but not in the lowest PP group, was significantly higher than in other PP groups. CONCLUSION:Pulse pressure lower than 45 mmHg and higher than 75 mmHg was closely associated with HFpEF prognosis, indicating the clinical significance of PP for risk stratification of HFpEF.
journal_name
Eur J Heart Failjournal_title
European journal of heart failureauthors
Tokitsu T,Yamamoto E,Hirata Y,Kusaka H,Fujisue K,Sueta D,Sugamura K,Sakamoto K,Tsujita K,Kaikita K,Hokimoto S,Sugiyama S,Ogawa Hdoi
10.1002/ejhf.559subject
Has Abstractpub_date
2016-11-01 00:00:00pages
1353-1361issue
11eissn
1388-9842issn
1879-0844journal_volume
18pub_type
杂志文章abstract:AIMS:To assess the prognostic value of a wide spectrum of neurohormonal and inflammatory markers along with functional status and exercise capacity, in hospitalized chronic heart failure (CHF) patients with depressive symptoms. METHODS AND RESULTS:A total of 300 consecutive hospitalized CHF patients were screened for ...
journal_title:European journal of heart failure
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doi:10.1093/eurjhf/hfp125
更新日期:2009-10-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1093/eurjhf/hfq198
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journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究
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journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
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更新日期:2007-11-01 00:00:00
abstract:AIMS:Pulmonary hypertension (PH) due to systolic left ventricular dysfunction (PH-sLVD) frequently complicates heart failure (HF), and greatly worsens the prognosis of patients with sLVD, but as yet has no approved treatment. The LEPHT study aims to characterize the haemodynamic profile, safety, tolerability, and pharm...
journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
doi:10.1093/eurjhf/hfs071
更新日期:2012-08-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究
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更新日期:2007-03-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2005.11.013
更新日期:2006-08-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章,多中心研究
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更新日期:2019-02-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2005.05.006
更新日期:2005-10-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.1601
更新日期:2020-02-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ejheart.2008.07.004
更新日期:2008-09-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2011-08-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/s1388-9842(02)00116-2
更新日期:2002-12-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.668
更新日期:2017-03-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/s1388-9842(02)00004-1
更新日期:2002-06-01 00:00:00
abstract:AIMS:The most recent European guidelines have proposed new definitions of pulmonary hypertension (PH) in left heart disease, to better approach the characteristics required to reflect the presence of pulmonary vascular disease. The purpose of this study was to assess whether different haemodynamic definitions of post-c...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.1067
更新日期:2018-04-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2008.05.001
更新日期:2008-07-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,评审
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更新日期:2017-03-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 临床试验,杂志文章
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更新日期:2007-09-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
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更新日期:2001-03-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2004.06.008
更新日期:2005-03-02 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.1740
更新日期:2020-05-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.2008
更新日期:2020-09-18 00:00:00
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journal_title:European journal of heart failure
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2004.03.003
更新日期:2004-12-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
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更新日期:1999-08-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,评审
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更新日期:2009-02-01 00:00:00