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Iron deficiency and red cell indices in patients with heart failure.

Abstract：

AIMS:To investigate the prevalence of iron deficiency (ID) in heart failure (HF) patients with normal vs. abnormal red cell indices (RCI), the associations between iron parameters and RCI, and prognostic consequences of ID independently of RCI. METHODS AND RESULTS:We analysed clinical data of 1821 patients with HF [mean age 66 ± 13 years; 71% men; New York Heart Association class I/II/III/IV (11%/39%/44%/6%); left ventricular ejection fraction >45%: 19%]. Iron deficiency (ferritin <100 µg/L or ferritin 100-299 µg/L with transferrin saturation <20%) was common irrespective of the presence of anaemia (haemoglobin <12 g/dL in women and <13 g/dL in men) or low RCI, from 75% in anaemic subjects with low mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), and MCH concentration (MCHC), to 36% in non-anaemic subjects with MCV, MCH, and MCHC above the lower limit of normal. After adjustment for clinical variables, iron parameters remained independently associated with haemoglobin, MCV, MCH, MCHC, mean reticulocyte haemoglobin content (CHR), and red cell distribution width (RDW). In multivariable Cox proportional hazard regression models there was a trend towards higher mortality in patients with vs. without ID when adjusted for relevant HF prognosticators and MCH or MCHC (but not haemoglobin, CHR or RDW). CONCLUSIONS:Patients with HF should be routinely screened for ID irrespective of the presence of anaemia or abnormal RCI. The detrimental impact of ID on long-term survival in HF is partially independent of RCI.

journal_name

Eur J Heart Fail

journal_title

European journal of heart failure

authors

Tkaczyszyn M,Comín-Colet J,Voors AA,van Veldhuisen DJ,Enjuanes C,Moliner-Borja P,Rozentryt P,Poloński L,Banasiak W,Ponikowski P,van der Meer P,Jankowska EA

doi

10.1002/ejhf.820

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

114-122

issue

1

eissn

1388-9842

issn

1879-0844

journal_volume

20

pub_type

杂志文章,多中心研究

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