Abstract:
AIMS:Women are more likely to develop heart failure with preserved ejection fraction (HFpEF) than men. We studied the relationship between sex and cardiovascular structure and function in patients with HFpEF. METHODS AND RESULTS:The study included 279 participants from the PARAMOUNT study (57% women) with analysable baseline echocardiograms (mean age 71 years, 94% hypertensive, 38% diabetic). We assessed sex-based differences in baseline clinical characteristics and measures of cardiovascular structure/function. Coronary artery disease was less common in women than in men. Women were more obese and symptomatic, and less likely to have albuminuria. Women had higher indexed left ventricular (LV) wall thicknesses, worse diastolic function (lower E', P = 0.002; higher E/E', P < 0.001), while LV mass and LV volumes indexed for height(2.7) were similar. Nonetheless, female sex was associated with a trend towards higher prevalence of abnormal LV geometry (defined as concentric hypertrophy, or eccentric hypertrophy, or concentric remodelling) at baseline (unadjusted P = 0.028, adjusted P = 0.056) and 12 weeks' follow up (unadjusted P = 0.001, adjusted P = 0.006), but not at 36 weeks' follow up (unadjusted P = 0.81, adjusted P = 0.99). Despite higher LV ejection fraction in women, global LV strain was similar between the sexes, while Tissue Doppler Imaging S' mitral velocity was lower in women. Both LV diastolic and systolic stiffness were higher in women than men (P < 0.001), even adjusting for LV concentricity and clinical covariates. We observed no sex differences in systolic arterial-LV coupling, as women also had higher absolute arterial elastance compared with men, although this difference was not significant after adjusting for height(2.7) . CONCLUSION:More pronounced diastolic dysfunction may contribute to the greater predisposition for HFpEF in women compared with men.
journal_name
Eur J Heart Failjournal_title
European journal of heart failureauthors
Gori M,Lam CS,Gupta DK,Santos AB,Cheng S,Shah AM,Claggett B,Zile MR,Kraigher-Krainer E,Pieske B,Voors AA,Packer M,Bransford T,Lefkowitz M,McMurray JJ,Solomon SD,PARAMOUNT Investigators.doi
10.1002/ejhf.67subject
Has Abstractpub_date
2014-05-01 00:00:00pages
535-42issue
5eissn
1388-9842issn
1879-0844journal_volume
16pub_type
杂志文章abstract::Heart failure (HF) in elderly patients is associated with more diffuse symptoms and signs due to the presence of other noncardiac comorbidities. This can cause difficulties in assessing the correct diagnosis and initiating appropriate therapy. The four most frequently occurring noncardiac comorbidities and therapies u...
journal_title:European journal of heart failure
pub_type: 杂志文章,评审
doi:10.1016/j.ejheart.2005.01.008
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abstract:AIMS:Beta-blockers (BBs) improve outcomes in heart failure. Results from the Cardiac Insufficiency Bisoprolol Study in Elderly (CIBIS-ELD) trial previously demonstrated the feasibility of heart rate, not maximum dose, as a treatment goal. In this pre-specified analysis, we investigated the prognostic value of achieved ...
journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
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更新日期:2014-08-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
doi:10.1093/eurjhf/hfq199
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journal_title:European journal of heart failure
pub_type: 杂志文章,评审
doi:10.1016/j.ejheart.2008.08.007
更新日期:2008-11-01 00:00:00
abstract::The use of Left Ventricular Assist Devices (LVADs) has increased over the last decade because of the lack of healthy donor hearts. In this report we describe for the first time a patient with an LVAD Heart Mate II (HM II) implanted 6 months before admission, who initially suffered from severe anaemia and later on unde...
journal_title:European journal of heart failure
pub_type: 杂志文章
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更新日期:2009-08-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2003.12.013
更新日期:2004-03-15 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/s1388-9842(00)00108-2
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journal_title:European journal of heart failure
pub_type: 杂志文章,评审
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journal_title:European journal of heart failure
pub_type: 杂志文章
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journal_title:European journal of heart failure
pub_type: 已发布勘误
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更新日期:2016-02-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究,评审
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更新日期:2018-09-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究
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journal_title:European journal of heart failure
pub_type: 杂志文章
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更新日期:2002-10-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.164
更新日期:2014-10-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.2016
更新日期:2020-10-02 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,评审
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更新日期:2018-02-01 00:00:00
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journal_title:European journal of heart failure
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
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更新日期:2016-09-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
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更新日期:2013-10-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2004.04.008
更新日期:2005-01-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/s1388-9842(00)00092-1
更新日期:2000-09-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2003.09.009
更新日期:2004-03-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
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更新日期:2015-11-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ejheart.2008.02.005
更新日期:2008-04-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,评审
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更新日期:2020-08-01 00:00:00