The prognostic significance of heart failure with preserved left ventricular ejection fraction: a literature-based meta-analysis.

Abstract:

AIMS:Heart failure (HF) with normal or preserved left ventricular (LV) ejection fraction (HFPEF) has been reported to be associated with similar outcome as HF with reduced EF (HFREF) in registry-based and epidemiological analyses, but many of these studies excluded patients who did not have EF measurements. Conversely, prior prospective studies have reported better outcome for patients with HFPEF. We performed a meta-analysis of prospective observational studies comparing all-cause mortality in patients with HFREF and HFPEF. METHODS AND RESULTS:We searched several online databases for studies comparing outcome in HFREF and HFPEF, published before 2007. INCLUSION CRITERIA:prospective, clinical HF, near complete EF data, and mortality outcome. Review Manager version 4.2.3 software was used for the analysis. Overall, 24 501 patients [9299 deaths (38%)] from 17 studies are included. Average follow-up was 47 months; the HFPEF group was older (69 vs. 66 years) and more likely to be female (44% vs. 26%). Of the 7688 patients with HFPEF 2468 died (32.1%), compared with 6831 of the 16 813 patients with HFREF (40.6%): odds ratio 0.51 (95% CI: 0.48, 0.55). CONCLUSION:This literature-based meta-analysis demonstrates that mortality among patients with HFPEF was half that observed in those with HFREF, in contrast to previous reports suggesting that mortality may be similar between both groups.

journal_name

Eur J Heart Fail

authors

Somaratne JB,Berry C,McMurray JJ,Poppe KK,Doughty RN,Whalley GA

doi

10.1093/eurjhf/hfp103

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

855-62

issue

9

eissn

1388-9842

issn

1879-0844

pii

hfp103

journal_volume

11

pub_type

杂志文章,meta分析
  • Hospitalization for congestive heart failure: is it still a cardiology business?

    abstract:BACKGROUND:Hospital management of CHF and predictors of hospital mortality remain unclear. METHODS:To address these issues, we analyzed the hospital admissions for CHF during 1996 in a large university hospital. Patients discharged with the principal diagnosis of CHF were considered eligible for the study. RESULTS:Am...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(01)00204-5

    authors: Grigioni F,Carinci V,Favero L,Bacchi Reggiani L,Magnani G,Potena L,Barbieri A,Magelli C,Branzi A,Magnani B

    更新日期:2002-01-01 00:00:00

  • Prognostic significance of new atrial fibrillation and its relation to heart failure following acute myocardial infarction.

    abstract:BACKGROUND:New-onset atrial fibrillation (AF) after acute myocardial infarction (AMI) frequently occurs in association with postinfarction complications, particularly with heart failure (HF). AIMS:To evaluate whether postinfarction HF is associated with the subsequent development of AF and whether AF independently pre...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2004.07.018

    authors: Asanin M,Perunicic J,Mrdovic I,Matic M,Vujisic-Tesic B,Arandjelovic A,Vasiljevic Z,Ostojic M

    更新日期:2005-06-01 00:00:00

  • Plasma N-terminal pro BNP and cardiotrophin-1 are elevated in aortic stenosis.

    abstract:BACKGROUND:Echocardiography with Doppler examination of the aortic valve provides a very accurate assessment of the transvalvular gradient and is used to monitor progression of aortic stenosis (AS). Plasma brain natriuretic peptide (BNP) has been shown to correlate with end-systolic wall stress in patients with AS. AI...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(00)00074-x

    authors: Talwar S,Downie PF,Squire IB,Davies JE,Barnett DB,Ng LL

    更新日期:2001-01-01 00:00:00

  • Echocardiographic screening for non-ischaemic stage B heart failure in the community.

    abstract:AIMS:Incident heart failure (HF) continues to pose a common and serious problem. We sought to examine the value of echocardiographic predictors of new HF in a community-based elderly population at risk for HF, independent of and incremental to clinical evaluation. METHODS AND RESULTS:Asymptomatic patients ≥65 years ol...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.643

    authors: Yang H,Negishi K,Wang Y,Nolan M,Saito M,Marwick TH

    更新日期:2016-11-01 00:00:00

  • Baseline characteristics and outcomes of patients with heart failure receiving bronchodilators in the CHARM programme.

    abstract:AIMS:Heart failure (HF) and chronic obstructive pulmonary disease are common partners. Bronchodilators are associated with adverse cardiovascular outcomes in patients with pulmonary disease. The outcome of patients with HF prescribed bronchodilators is poorly defined. METHODS AND RESULTS:The Candesartan in Heart failu...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurjhf/hfq040

    authors: Hawkins NM,Wang D,Petrie MC,Pfeffer MA,Swedberg K,Granger CB,Yusuf S,Solomon SD,Ostergren J,Michelson EL,Pocock SJ,Maggioni AP,McMurray JJ,CHARM Investigators and Committees.

    更新日期:2010-06-01 00:00:00

  • Heart failure prognosis over time: how the prognostic role of oxygen consumption and ventilatory efficiency during exercise has changed in the last 20 years.

    abstract:AIMS:Exercise-derived parameters, specifically peak exercise oxygen uptake (peak VO2 ) and minute ventilation/carbon dioxide relationship slope (VE/VCO2 slope), have a pivotal prognostic value in heart failure (HF). It is unknown how the prognostic threshold of peak VO2 and VE/VCO2 slope has changed over the last 20 ye...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ejhf.1364

    authors: Paolillo S,Veglia F,Salvioni E,Corrà U,Piepoli M,Lagioia R,Limongelli G,Sinagra G,Cattadori G,Scardovi AB,Metra M,Senni M,Bonomi A,Scrutinio D,Raimondo R,Emdin M,Magrì D,Parati G,Re F,Cicoira M,Minà C,Correale M

    更新日期:2019-02-01 00:00:00

  • Prognostic utility of plasma neutrophil gelatinase-associated lipocalin in patients with acute heart failure: the NGAL EvaLuation Along with B-type NaTriuretic Peptide in acutely decompensated heart failure (GALLANT) trial.

    abstract:AIMS:Neutrophil gelatinase-associated lipocalin (NGAL) is a measure of acute kidney injury. Renal dysfunction portends significant risk after discharge from acute heart failure (AHF). Thus, a sensitive marker of renal injury might also help to risk stratify HF patients. METHODS AND RESULTS:GALLANT [NGAL EvaLuation Alo...

    journal_title:European journal of heart failure

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1093/eurjhf/hfr087

    authors: Maisel AS,Mueller C,Fitzgerald R,Brikhan R,Hiestand BC,Iqbal N,Clopton P,van Veldhuisen DJ

    更新日期:2011-08-01 00:00:00

  • Haemodynamic effects of an acute vasodilator challenge in heart failure patients with reduced ejection fraction and different forms of post-capillary pulmonary hypertension.

    abstract:AIMS:The most recent European guidelines have proposed new definitions of pulmonary hypertension (PH) in left heart disease, to better approach the characteristics required to reflect the presence of pulmonary vascular disease. The purpose of this study was to assess whether different haemodynamic definitions of post-c...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.1067

    authors: Ghio S,Crimi G,Temporelli PL,Traversi E,La Rovere MT,Cannito A,Vizza D,Scelsi L,Raineri C,Guazzi M,Oltrona Visconti L

    更新日期:2018-04-01 00:00:00

  • The role of plasma biomarkers in acute heart failure. Serial changes and independent prognostic value of NT-proBNP and cardiac troponin-T.

    abstract:AIMS:Brain natriuretic peptide (BNP), NT-proBNP and troponins are useful for the assessment of patients with heart failure. Few data exist about their serial changes and their prognostic value in patients with acute heart failure (AHF). METHODS AND RESULTS:NT-proBNP and troponin-T plasma levels were measured at baseli...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2007.05.007

    authors: Metra M,Nodari S,Parrinello G,Specchia C,Brentana L,Rocca P,Fracassi F,Bordonali T,Milani P,Danesi R,Verzura G,Chiari E,Dei Cas L

    更新日期:2007-08-01 00:00:00

  • Low value of simple echocardiographic indices of ventricular dyssynchrony in predicting the response to cardiac resynchronization therapy.

    abstract:AIMS:A recent study suggested that no single echocardiographic index of cardiac dyssynchrony can reliably identify candidates for cardiac resynchronization therapy (CRT). We examined the value of three simple echocardiographic indices for predicting the 6-month clinical and echocardiographic responses to CRT. METHODS ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurjhf/hfq058

    authors: Bordachar P,Lafitte S,Réant P,Reuter S,Clementy J,Mletzko RU,Siegel RM,Goscinska-Bis K,Bowes R,Morgan J,Bénard S,Leclercq C

    更新日期:2010-06-01 00:00:00

  • Desmin accumulation restrictive cardiomyopathy and atrioventricular block associated with desmin gene defects.

    abstract:BACKGROUND:Primary desminopathies are caused by desmin gene [DES (MIM*125660)] mutations. The clinical spectrum includes pure myopathies, cardiomuscular diseases and cardiomyopathies. Patients with restrictive cardiomyopathy (RCM) plus atrioventricular block (AVB) due to DES defects are frequently unrecognized unless d...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2005.11.003

    authors: Arbustini E,Pasotti M,Pilotto A,Pellegrini C,Grasso M,Previtali S,Repetto A,Bellini O,Azan G,Scaffino M,Campana C,Piccolo G,Viganò M,Tavazzi L

    更新日期:2006-08-01 00:00:00

  • Increasing glucose levels and BMI predict future heart failure experience from the Reykjavík Study.

    abstract:BACKGROUND:Heart failure is common in diabetes and ischaemic heart disease is the most likely link. Still, it has been suggested that the relation extends beyond such disease. METHODS:7060 subjects with two or more visits in the Reykjavík Study were followed--during 30 years from 1967. All underwent oral glucose toler...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2007.07.017

    authors: Thrainsdottir IS,Aspelund T,Gudnason V,Malmberg K,Sigurdsson G,Thorgeirsson G,Hardarson T,Rydén L

    更新日期:2007-10-01 00:00:00

  • Which patients with heart failure should receive specialist palliative care?

    abstract:AIMS:We investigated which patients with heart failure (HF) should receive specialist palliative care (SPC) by first creating a definition of need for SPC in patients hospitalised with HF using patient-reported outcome measures (PROMs) and then testing this definition using the outcome of days alive and out of hospital...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.1240

    authors: Campbell RT,Petrie MC,Jackson CE,Jhund PS,Wright A,Gardner RS,Sonecki P,Pozzi A,McSkimming P,McConnachie A,Finlay F,Davidson P,Denvir MA,Johnson MJ,Hogg KJ,McMurray JJV

    更新日期:2018-09-01 00:00:00

  • A functional variant of the neuropeptide S receptor-1 gene modulates clinical outcomes and healthcare utilization in patients with systolic heart failure: results from the Interdisciplinary Network Heart Failure (INH) Study.

    abstract:AIMS:Psychopathologies may occur in heart failure (HF) and can be associated with adverse outcomes. Amongst neuropeptide S receptor gene functional sequence variants, the T-allele [asparagine(107)isoleucine, NPSR1 rs324981] has been identified as a risk factor for increased anxiety/overinterpretation of bodily symptoms...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.706

    authors: Angermann CE,Kaspar M,Marx A,Kittel-Schneider S,Menhofer D,Störk S,Ertl G,Domschke K,Deckert J,Reif A

    更新日期:2017-03-01 00:00:00

  • Corrigendum to 'What does the lay public know about heart failure? Findings from the Heart Failure Awareness Day Initiative'[Eur J Heart Fail 2016; 18:66-70].

    abstract::The published version of this paper contained an error. The part C of the figure only has the header "multiple organs", whereas it must read: “HF does not affect multiple organs”. ...

    journal_title:European journal of heart failure

    pub_type: 已发布勘误

    doi:10.1002/ejhf.499

    authors:

    更新日期:2016-02-01 00:00:00

  • Telomere biology in heart failure.

    abstract::The incidence and prevalence of cardiovascular disease increases progressively with advancing age. Cardiovascular disease is a major cause of morbidity and mortality in Western Countries. In the near future, as the population ages, it is expected that the population prevalence of cardiovascular disease will increase d...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejheart.2008.08.007

    authors: Wong LS,de Boer RA,Samani NJ,van Veldhuisen DJ,van der Harst P

    更新日期:2008-11-01 00:00:00

  • COMBAT--conventional versus multisite pacing for bradyarrhythmia therapy: rationale of a prospective randomized multicenter study.

    abstract::COMBAT is a prospective, multicenter, randomized, blinded clinical study, with crossover design. The main objective is the comparative evaluation of atrio-biventricular versus conventional atrioventricular stimulation (atrio and right ventricle) in patients with heart failure and bradycardia as the primary indication ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2004.06.008

    authors: Martinelli M,Costa R,de Siqueira SF,Ramires JA

    更新日期:2005-03-02 00:00:00

  • Incidence of cancer in patients with chronic heart failure: a long-term follow-up study.

    abstract:AIMS:With improvement in survival of chronic heart failure (HF), the clinical importance of co-morbidity is increasing. The aim of this study was to assess the incidence and risk of cancer and all-cause mortality in a large Danish HF cohort. METHODS AND RESULTS:A total of 9307 outpatients with verified HF without a pr...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.472

    authors: Banke A,Schou M,Videbaek L,Møller JE,Torp-Pedersen C,Gustafsson F,Dahl JS,Køber L,Hildebrandt PR,Gislason GH

    更新日期:2016-03-01 00:00:00

  • Plasma B-type natriuretic peptide and anti-inflammatory cytokine interleukin-10 levels predict adverse clinical outcome in chronic heart failure patients with depressive symptoms: a 1-year follow-up study.

    abstract:AIMS:To assess the prognostic value of a wide spectrum of neurohormonal and inflammatory markers along with functional status and exercise capacity, in hospitalized chronic heart failure (CHF) patients with depressive symptoms. METHODS AND RESULTS:A total of 300 consecutive hospitalized CHF patients were screened for ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfp125

    authors: Parissis JT,Farmakis D,Nikolaou M,Birmpa D,Bistola V,Paraskevaidis I,Ikonomidis I,Gaitani S,Venetsanou K,Filippatos G,Kremastinos DT

    更新日期:2009-10-01 00:00:00

  • Does the physical examination still have a role in patients with suspected heart failure?

    abstract:AIMS:The prognostic value of signs of congestion in patients suspected of having chronic heart failure (CHF) is unknown. Our objectives were to define their prevalence and specificity in diagnosing CHF and to determine their prognostic value in patients in a community heart failure clinic. METHODS AND RESULTS:Analysis...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurjhf/hfr128

    authors: Damy T,Kallvikbacka-Bennett A,Zhang J,Goode K,Buga L,Hobkirk J,Yassin A,Dubois-Randé JL,Hittinger L,Cleland JG,Clark AL

    更新日期:2011-12-01 00:00:00

  • Connecting heart failure with preserved ejection fraction and renal dysfunction: the role of endothelial dysfunction and inflammation.

    abstract::Renal dysfunction in heart failure with preserved ejection fraction (HFpEF) is common and is associated with increased mortality. Impaired renal function is also a risk factor for developing HFpEF. A new paradigm for HFpEF, proposing a sequence of events leading to myocardial remodelling and dysfunction in HFpEF, was ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1002/ejhf.497

    authors: Ter Maaten JM,Damman K,Verhaar MC,Paulus WJ,Duncker DJ,Cheng C,van Heerebeek L,Hillege HL,Lam CS,Navis G,Voors AA

    更新日期:2016-06-01 00:00:00

  • A prognostic index to predict long-term mortality in patients with mild to moderate chronic heart failure stabilised on angiotensin converting enzyme inhibitors.

    abstract:BACKGROUND:Mortality in patients with mild to moderate chronic heart failure remains high. At present there is no easy way of identifying patients within this population at increased risk of death in the medium to long term. AIMS:To develop a prognostic index to identify outpatients with mild to moderate chronic heart...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(03)00053-9

    authors: Kearney MT,Nolan J,Lee AJ,Brooksby PW,Prescott R,Shah AM,Zaman AG,Eckberg DL,Lindsay HS,Batin PD,Andrews R,Fox KA

    更新日期:2003-08-01 00:00:00

  • Effects of exercise training on depression in patients with heart failure: a systematic review and meta-analysis of randomized controlled trials.

    abstract:AIMS:The aim of this review is to assess the effects of exercise training on the symptoms of depression in heart failure (HF) patients. METHODS AND RESULTS:Randomized controlled trials of exercise training in patients with HF and symptoms of depression were identified. The depression data were pooled using meta-analys...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/ejhf.101

    authors: Tu RH,Zeng ZY,Zhong GQ,Wu WF,Lu YJ,Bo ZD,He Y,Huang WQ,Yao LM

    更新日期:2014-07-01 00:00:00

  • Urine proteome analysis in heart failure with reduced ejection fraction complicated by chronic kidney disease: feasibility, and clinical and pathogenetic correlates.

    abstract:AIMS:Urine proteome analysis (UPA) has already provided accurate discriminatory patterns of urinary peptides for renal disease, coronary artery disease, and asymptomatic LV diastolic dysfunction. UPA has now been used to characterize a discriminatory peptide biomarker pattern and establish a diagnostic classifier for h...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.544

    authors: Farmakis D,Koeck T,Mullen W,Parissis J,Gogas BD,Nikolaou M,Lekakis J,Mischak H,Filippatos G

    更新日期:2016-07-01 00:00:00

  • Usefulness of anti-oxidized LDL antibody determination for assessment of clinical control in patients with heart failure.

    abstract:BACKGROUND:It has been suggested that oxidative stress may play a role in the pathogenesis of heart failure, this may have potential implications for therapeutic strategies. However, measures of oxidative stress are subject to confounding inaccuracies. IgG antibodies to oxidized LDL reflect exposure to the lipoprotein ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2005.04.015

    authors: George J,Wexler D,Roth A,Barak T,Sheps D,Keren G

    更新日期:2006-01-01 00:00:00

  • Self-care of heart failure patients: practical management recommendations from the Heart Failure Association of the European Society of Cardiology.

    abstract::Self-care is essential in the long-term management of chronic heart failure. Heart failure guidelines stress the importance of patient education on treatment adherence, lifestyle changes, symptom monitoring and adequate response to possible deterioration. Self-care is related to medical and person-centred outcomes in ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.2008

    authors: Jaarsma T,Hill L,Bayes-Genis A,La Rocca HB,Castiello T,Čelutkienė J,Marques-Sule E,Plymen CM,Piper SE,Riegel B,Rutten FH,Ben Gal T,Bauersachs J,Coats AJS,Chioncel O,Lopatin Y,Lund LH,Lainscak M,Moura B,Mullens W,P

    更新日期:2020-09-18 00:00:00

  • Determinants of extracellular matrix remodelling are differentially expressed in paediatric and adult dilated cardiomyopathy.

    abstract:AIMS:The left ventricular phenotype of idiopathic dilated cardiomyopathy (DCM) can appear similar in paediatric and adult patients. However, the aetiology of paediatric DCM is usually idiopathic, and often leads an aggressive clinical course. A structural underpinning of DCM is extracellular matrix changes, which are d...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfq184

    authors: Hsia TY,Ringewald JM,Stroud RE,Forbus GA,Bradley SM,Chung WK,Spinale FG

    更新日期:2011-03-01 00:00:00

  • Timing of eplerenone initiation and outcomes in patients with heart failure after acute myocardial infarction complicated by left ventricular systolic dysfunction: insights from the EPHESUS trial.

    abstract:AIMS:To test the hypothesis that an earlier post-acute myocardial infarction (AMI) eplerenone initiation in patients with left ventricular systolic dysfunction (LVSD) and heart failure (HF) is associated with better long-term outcomes. METHODS AND RESULTS:The 6632 patients of the EPHESUS study were randomized from day...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurjhf/hfp136

    authors: Adamopoulos C,Ahmed A,Fay R,Angioi M,Filippatos G,Vincent J,Pitt B,Zannad F,EPHESUS Investigators.

    更新日期:2009-11-01 00:00:00

  • Heart failure with preserved ejection fraction induces molecular, mitochondrial, histological, and functional alterations in rat respiratory and limb skeletal muscle.

    abstract:AIMS:Peripheral muscle dysfunction is a key mechanism contributing to exercise intolerance (i.e. breathlessness and fatigue) in heart failure patients with preserved ejection fraction (HFpEF); however, the underlying molecular and cellular mechanisms remain unknown. We therefore used an animal model to elucidate potent...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.239

    authors: Bowen TS,Rolim NP,Fischer T,Baekkerud FH,Medeiros A,Werner S,Brønstad E,Rognmo O,Mangner N,Linke A,Schuler G,Silva GJ,Wisløff U,Adams V,Optimex Study Group.

    更新日期:2015-03-01 00:00:00

  • The dynamic assessment of right-ventricular function and its relation to exercise capacity in heart failure.

    abstract:AIMS:To evaluate right-ventricular (RV) function during stress echocardiography (SE) and to assess its relationship with exercise capacity in heart failure (HF) patients. METHODS AND RESULTS:We included 88 patients aged 60.9 +/- 11.2 years with a mean LVEF of 27.2 +/- 9.5%. The following RV parameters were measured at...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfp200

    authors: Rubis P,Podolec P,Kopec G,Olszowska M,Tracz W

    更新日期:2010-03-01 00:00:00