Prognostic importance of cognitive impairment in chronic heart failure patients: does specialist management make a difference?

Abstract:

BACKGROUND:Cognitive impairment is common among chronic heart failure (CHF) patients. AIMS:To determine the prognostic significance of cognitive impairment in patients participating in a randomized study of a CHF management program (CHF-MP). METHODS:CHF patients were randomized to a CHF-MP (n=100) or usual care (n=100). Baseline cognition was assessed using the Mini Mental Status Examination (MMSE). Five-year all-cause mortality, and combined death-or-readmission, were compared on the basis of the presence (MMSE 19-26) or absence (MMSE >26) of cognitive impairment. RESULTS:27 patients (13.5%) had cognitive impairment and, on an adjusted basis, were more likely to die (96.3% versus 68.2%. RR 2.19, 95% CI 1.41 to 3.39: P<0.001) and/or experience an unplanned hospitalization (100% versus 94%. RR 1.44, 95% CI 1.06 to 1.95: P=0.019). Cognitively impaired patients had a similar (non-significant) adjusted risk of death-or-readmission in both the CHF-MP (RR 1.40, 95% CI 0.63 to 3.11: P=0.403) and in usual care (RR 1.38, 95% CI 0.75 to 2.53: P=0.305). In the usual care cohort, cognitive impairment was associated with a greater (non-significant), adjusted risk of death (RR 1.61, 95% CI 1.10 to 4.92: P=0.122). In the CHF-MP, adjusted risk of death was significantly higher for cognitively impaired patients (RR 2.33, 95% CI 1.10 to 4.92: P=0.027). CONCLUSION:These data suggest that "mild" cognitive impairment is of prognostic importance in CHF: even when a CHF-MP has been applied.

journal_name

Eur J Heart Fail

authors

McLennan SN,Pearson SA,Cameron J,Stewart S

doi

10.1016/j.ejheart.2005.11.013

keywords:

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

494-501

issue

5

eissn

1388-9842

issn

1879-0844

pii

S1388-9842(05)00327-2

journal_volume

8

pub_type

杂志文章
  • Lung congestion in chronic heart failure: haemodynamic, clinical, and prognostic implications.

    abstract:AIMS:The goal of the study was to examine the prognostic impact, haemodynamic and clinical features associated with lung congestion in patients with chronic heart failure (HF). METHODS AND RESULTS:HF patients (n = 186) and HF-free controls (n = 21) underwent right heart catheterization, echocardiography, pulmonary fun...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.417

    authors: Melenovsky V,Andersen MJ,Andress K,Reddy YN,Borlaug BA

    更新日期:2015-11-01 00:00:00

  • Echocardiographic screening for non-ischaemic stage B heart failure in the community.

    abstract:AIMS:Incident heart failure (HF) continues to pose a common and serious problem. We sought to examine the value of echocardiographic predictors of new HF in a community-based elderly population at risk for HF, independent of and incremental to clinical evaluation. METHODS AND RESULTS:Asymptomatic patients ≥65 years ol...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.643

    authors: Yang H,Negishi K,Wang Y,Nolan M,Saito M,Marwick TH

    更新日期:2016-11-01 00:00:00

  • Heart failure with preserved ejection fraction induces molecular, mitochondrial, histological, and functional alterations in rat respiratory and limb skeletal muscle.

    abstract:AIMS:Peripheral muscle dysfunction is a key mechanism contributing to exercise intolerance (i.e. breathlessness and fatigue) in heart failure patients with preserved ejection fraction (HFpEF); however, the underlying molecular and cellular mechanisms remain unknown. We therefore used an animal model to elucidate potent...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.239

    authors: Bowen TS,Rolim NP,Fischer T,Baekkerud FH,Medeiros A,Werner S,Brønstad E,Rognmo O,Mangner N,Linke A,Schuler G,Silva GJ,Wisløff U,Adams V,Optimex Study Group.

    更新日期:2015-03-01 00:00:00

  • Concomitant implantation of Impella® on top of veno-arterial extracorporeal membrane oxygenation may improve survival of patients with cardiogenic shock.

    abstract:AIMS:Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support stabilizes patients with cardiogenic shock. Despite improved oxygenation and peripheral circulation, LV unloading may be impeded due to the increased afterload, resulting in a failing static left ventricle and in high mortality. METHODS AND RESUL...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.668

    authors: Pappalardo F,Schulte C,Pieri M,Schrage B,Contri R,Soeffker G,Greco T,Lembo R,Müllerleile K,Colombo A,Sydow K,De Bonis M,Wagner F,Reichenspurner H,Blankenberg S,Zangrillo A,Westermann D

    更新日期:2017-03-01 00:00:00

  • Right ventricular dysfunction in heart failure with preserved ejection fraction: a systematic review and meta-analysis.

    abstract:AIMS:Right ventricular (RV) dysfunction and pulmonary hypertension (PH) are increasingly recognized in heart failure with preserved ejection fraction (HFpEF). The prevalence and prognostic value of RV dysfunction in HFpEF have been widely but variably reported. We therefore conducted a systematic review and meta-analys...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/ejhf.630

    authors: Gorter TM,Hoendermis ES,van Veldhuisen DJ,Voors AA,Lam CS,Geelhoed B,Willems TP,van Melle JP

    更新日期:2016-12-01 00:00:00

  • The conundrum of patients with obesity, exercise intolerance, elevated ventricular filling pressures and a measured ejection fraction in the normal range.

    abstract::Patients with obesity, a reduced exercise capacity, increased cardiac filling pressures and a measured left ventricular ejection fraction in the normal range do not have a homogeneous disorder, but instead, exhibit one of three phenotypes. First, many obese people exhibit sodium retention, plasma volume expansion and ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1002/ejhf.1377

    authors: Packer M

    更新日期:2019-02-01 00:00:00

  • Dietary sodium modulation of aldosterone activation and renal function during the progression of experimental heart failure.

    abstract:AIMS:Aldosterone activation is central to the sodium–fluid retention that marks the progression of heart failure (HF). The actions of dietary sodium restriction, a mainstay in HF management, on cardiorenal and neuroendocrine adaptations during the progression of HF are poorly understood. The study aim was to assess the...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.212

    authors: Miller WL,Borgeson DD,Grantham JA,Luchner A,Redfield MM,Burnett JC Jr

    更新日期:2015-02-01 00:00:00

  • Endomyocardial miR-133a levels correlate with myocardial inflammation, improved left ventricular function, and clinical outcome in patients with inflammatory cardiomyopathy.

    abstract:AIMS:Inflammatory heart disease represents an important cause of chronic dilated cardiomyopathy (DCM). Predicting the clinical course of patients with inflammatory cardiomyopathy (iCMP) is difficult, and the prognostic value of current biological markers remains controversial. We tested whether expression of selected m...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.579

    authors: Besler C,Urban D,Watzka S,Lang D,Rommel KP,Kandolf R,Klingel K,Thiele H,Linke A,Schuler G,Adams V,Lurz P

    更新日期:2016-12-01 00:00:00

  • Plasma N-terminal pro BNP and cardiotrophin-1 are elevated in aortic stenosis.

    abstract:BACKGROUND:Echocardiography with Doppler examination of the aortic valve provides a very accurate assessment of the transvalvular gradient and is used to monitor progression of aortic stenosis (AS). Plasma brain natriuretic peptide (BNP) has been shown to correlate with end-systolic wall stress in patients with AS. AI...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(00)00074-x

    authors: Talwar S,Downie PF,Squire IB,Davies JE,Barnett DB,Ng LL

    更新日期:2001-01-01 00:00:00

  • Renal denervation in heart failure with preserved ejection fraction (RDT-PEF): a randomized controlled trial.

    abstract:AIM:Heart failure with preserved ejection fraction (HFpEF) is associated with increased sympathetic nervous system (SNS) tone. Attenuating the SNS with renal denervation (RDT) might be helpful and there are no data currently in humans with HFpEF. METHODS AND RESULTS:In this single-centre, randomized, open-controlled s...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/ejhf.502

    authors: Patel HC,Rosen SD,Hayward C,Vassiliou V,Smith GC,Wage RR,Bailey J,Rajani R,Lindsay AC,Pennell DJ,Underwood SR,Prasad SK,Mohiaddin R,Gibbs JS,Lyon AR,Di Mario C

    更新日期:2016-06-01 00:00:00

  • Increasing glucose levels and BMI predict future heart failure experience from the Reykjavík Study.

    abstract:BACKGROUND:Heart failure is common in diabetes and ischaemic heart disease is the most likely link. Still, it has been suggested that the relation extends beyond such disease. METHODS:7060 subjects with two or more visits in the Reykjavík Study were followed--during 30 years from 1967. All underwent oral glucose toler...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2007.07.017

    authors: Thrainsdottir IS,Aspelund T,Gudnason V,Malmberg K,Sigurdsson G,Thorgeirsson G,Hardarson T,Rydén L

    更新日期:2007-10-01 00:00:00

  • The prevalence and incidence of left bundle branch block in ambulant patients with chronic heart failure.

    abstract:BACKGROUND:Approximately one third of patients with chronic heart failure have left bundle branch block (LBBB) on their 12-lead ECG. METHODS AND RESULTS:1418 consecutive patients (average (SD) age 70.5 (10.4) years; 74% male) first seen in a community heart failure clinic between December 2001 and June 2006 had a 12 l...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2008.05.001

    authors: Clark AL,Goode K,Cleland JG

    更新日期:2008-07-01 00:00:00

  • Serial measurement of galectin-3 in patients with chronic heart failure: results from the ProBNP Outpatient Tailored Chronic Heart Failure Therapy (PROTECT) study.

    abstract:AIMS:Galectin-3 is a prognostic heart failure (HF) biomarker that may mediate cardiac fibrosis. We examined the value of serial galectin-3 measurement for prognosis and response to therapy in chronic HF. METHODS AND RESULTS:A total of 151 subjects with LV systolic dysfunction (LVSD) were followed through 908 visits ov...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hft075

    authors: Motiwala SR,Szymonifka J,Belcher A,Weiner RB,Baggish AL,Sluss P,Gaggin HK,Bhardwaj A,Januzzi JL

    更新日期:2013-10-01 00:00:00

  • Association of low body temperature and poor outcomes in patients admitted with worsening heart failure: a substudy of the Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study with Tolvaptan (EVEREST) trial.

    abstract:AIMS:Risk stratification in patients admitted with worsening heart failure (HF) is essential for tailoring therapy and counselling. Risk models are available but rarely used, in part because many require laboratory and imaging results that are not routinely available. Body temperature is associated with prognosis in ot...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurjhf/hft113

    authors: Payvar S,Spertus JA,Miller AB,Casscells SW,Pang PS,Zannad F,Swedberg K,Maggioni AP,Reid KJ,Gheorghiade M,Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study with Tolvaptan (EVEREST) Investigators.

    更新日期:2013-12-01 00:00:00

  • Levosimendan improves renal function in acute decompensated heart failure: possible underlying mechanisms.

    abstract:AIMS:The cardio-renal syndrome plays a critical role in acute heart failure (HF). Levosimendan, an inodilator drug, has a positive but controversial effect on kidney. Our aim was to evaluate its effects on both renal and systemic haemodynamic parameters as well as on renal function, explaining the possible mechanisms i...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/ejhf.9

    authors: Fedele F,Bruno N,Brasolin B,Caira C,D'Ambrosi A,Mancone M

    更新日期:2014-03-01 00:00:00

  • Residual stress ischaemia is associated with blood markers of myocardial structural remodelling.

    abstract:BACKGROUND:Long-term prognosis of coronary artery disease (CAD) patients is worsened when stress ischemia persists on treatment, but the relationship with adverse cardiac remodelling had never been investigated. AIM:To analyze changes in blood markers of fibrosis in patients with chronic CAD exhibiting exercise ischae...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2006.09.010

    authors: Radauceanu A,Moulin F,Djaballah W,Marie PY,Alla F,Dousset B,Virion JM,Capiaumont J,Karcher G,Aliot E,Zannad F

    更新日期:2007-04-01 00:00:00

  • Telemedical Interventional Monitoring in Heart Failure (TIM-HF), a randomized, controlled intervention trial investigating the impact of telemedicine on mortality in ambulatory patients with heart failure: study design.

    abstract:AIMS:Remote patient management (telemonitoring) may help to detect early signs of cardiac decompensation, allowing optimization of and adherence to treatments in chronic heart failure (CHF). Two meta-analyses have suggested that telemedicine in CHF can reduce mortality by 30-35%. The aim of the TIM-HF study was to inve...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurjhf/hfq199

    authors: Koehler F,Winkler S,Schieber M,Sechtem U,Stangl K,Böhm M,Boll H,Kim SS,Koehler K,Lücke S,Honold M,Heinze P,Schweizer T,Braecklein M,Kirwan BA,Gelbrich G,Anker SD,TIM-HF Investigators.

    更新日期:2010-12-01 00:00:00

  • Clinical trials update from the American Heart Association: REPAIR-AMI, ASTAMI, JELIS, MEGA, REVIVE-II, SURVIVE, and PROACTIVE.

    abstract::This article provides information and a commentary on trials presented at the American Heart Association meeting held in November 2005, relevant to the pathophysiology, prevention and treatment of heart failure. All reports should be considered as preliminary data, as analyses may change in the final publication. In R...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejheart.2005.12.003

    authors: Cleland JG,Freemantle N,Coletta AP,Clark AL

    更新日期:2006-01-01 00:00:00

  • Desmin accumulation restrictive cardiomyopathy and atrioventricular block associated with desmin gene defects.

    abstract:BACKGROUND:Primary desminopathies are caused by desmin gene [DES (MIM*125660)] mutations. The clinical spectrum includes pure myopathies, cardiomuscular diseases and cardiomyopathies. Patients with restrictive cardiomyopathy (RCM) plus atrioventricular block (AVB) due to DES defects are frequently unrecognized unless d...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2005.11.003

    authors: Arbustini E,Pasotti M,Pilotto A,Pellegrini C,Grasso M,Previtali S,Repetto A,Bellini O,Azan G,Scaffino M,Campana C,Piccolo G,Viganò M,Tavazzi L

    更新日期:2006-08-01 00:00:00

  • European Society of Cardiology Working Group on Adult Congenital Heart Disease and Study Group for Adult Congenital Heart Care in Central and South Eastern European Countries consensus paper: current status, provision gaps and investment required.

    abstract:AIMS:To examine the current status of care and needs of adult congenital heart disease (ACHD) services in the Central and South Eastern European (CESEE) region. METHODS AND RESULTS:We obtained data regarding the national ACHD status for 19 CESEE countries from their ACHD representative based on an extensive survey for...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.2040

    authors: Brida M,Šimkova I,Jovović L,Prokšelj K,Antonová P,Balint HO,Gumbiene L,Lebid IH,Komar M,Kratunkov P,Kovačević Preradović T,Ermel R,Strenge A,Coman IM,Vukomanović V,Gatzoulis MA,Roos-Hesselink JW,Diller GP

    更新日期:2020-11-02 00:00:00

  • High prevalence of subclinical cerebral infarction in patients with heart failure with preserved ejection fraction.

    abstract:AIMS:Undetected atrial fibrillation (AF) may be common in the heart failure with preserved ejection fraction (HFpEF) population, and failure to detect this may lead to the missing of opportunities to prevent associated subclinical cerebral infarctions (SCIs) and cognitive decline. METHODS AND RESULTS:We studied 1527 p...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.812

    authors: Cogswell RJ,Norby FL,Gottesman RF,Chen LY,Solomon S,Shah A,Alonso A

    更新日期:2017-10-01 00:00:00

  • EURObservational Research Programme: a worldwide registry on peripartum cardiomyopathy (PPCM) in conjunction with the Heart Failure Association of the European Society of Cardiology Working Group on PPCM.

    abstract:BACKGROUND:The EURObservational Research Programme is a rolling programme of cardiovascular registries and surveys of the European Society of Cardiology (ESC). These registries will provide information on the nature of cardiovascular disease and its management. This manuscript provides an update on new literature on pe...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.68

    authors: Sliwa K,Hilfiker-Kleiner D,Mebazaa A,Petrie MC,Maggioni AP,Regitz-Zagrosek V,Schaufelberger M,Tavazzi L,van Veldhuisen DJ,Roos-Hesslink JW,Shah AJ,Seferovic PM,Elkayam U,van Spaendonck-Zwarts K,Bachelier-Walenta K,Mouquet F

    更新日期:2014-05-01 00:00:00

  • The effect of aspirin on the ventilatory response to exercise in chronic heart failure.

    abstract:INTRODUCTION:Patients with chronic heart failure (CHF) experience breathlessness and fatigue on exercise. One of the abnormalities seen on maximal exercise testing is an increased ventilatory response to exercise (VE/VCO(2) slope). The cause of this is unknown, but is likely to be due to a combination of interacting pe...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2003.11.008

    authors: Witte KK,Clark AL

    更新日期:2004-10-01 00:00:00

  • Prevalence and prognostic significance of atrial fibrillation in outpatients with heart failure due to left ventricular systolic dysfunction.

    abstract:INTRODUCTION:Atrial fibrillation (AF) is common in patients with heart failure (HF) due to left ventricular systolic dysfunction (LVSD), with conflicting prognostic data. The aim of our study was to assess the prevalence and incidence of AF in patients with HF and to determine the prognostic impact of baseline AF and t...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ejheart.2006.08.004

    authors: Corell P,Gustafsson F,Schou M,Markenvard J,Nielsen T,Hildebrandt P

    更新日期:2007-03-01 00:00:00

  • Attenuation of postoperative noradrenaline need by nitric oxide inhibition using L-NMMA.

    abstract::In the present report we describe that NG-monomethyl-L-arginine acetate, a non-specific nitric oxide synthesis inhibitor, administered at 1 mg kg(-1) h(-1) to a patient with critical hypotension following mitral valve surgery combined with passive containment surgery, increased the urinary output and arterial blood pr...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2005.02.001

    authors: Franco-Cereceda A,Holm P,Bredin F,Adding C

    更新日期:2005-12-01 00:00:00

  • Left atrial volume predicts abnormal exercise left ventricular filling pressure.

    abstract:AIMS:Latent heart failure at rest can be observed in a number of patients upon exercise. Considering left atrial (LA) remodelling as the reflection of the cumulative effects of the LV filling pressure (FP) over time, our aim was to investigate whether the LA volume would predict abnormal exercise LVFP. METHODS AND RES...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.131

    authors: Hammoudi N,Achkar M,Laveau F,Boubrit L,Djebbar M,Allali Y,Komajda M,Isnard R

    更新日期:2014-10-01 00:00:00

  • Clinical trials update from the European Society of Cardiology Meeting 2010: SHIFT, PEARL-HF, STAR-heart, and HEBE-III.

    abstract::This article provides information and a commentary on key trials relevant to the pathophysiology, prevention, and treatment of heart failure (HF) presented at the annual meeting of the European Society of Cardiology held in Stockholm in 2010. Unpublished reports should be considered as preliminary, since analyses may ...

    journal_title:European journal of heart failure

    pub_type:

    doi:10.1093/eurjhf/hfq186

    authors: Cleland JG,Coletta AP,Torabi A,Ahmed D,Clark AL

    更新日期:2010-11-01 00:00:00

  • Myocardial gene expression alterations in peripheral blood mononuclear cells of patients with idiopathic dilated cardiomyopathy.

    abstract:AIMS:To assess cardiac gene expression in peripheral blood cells of patients with idiopathic dilated cardiomyopathy (IDCM) and its relationship to echocardiographic left ventricular (LV) function. METHODS AND RESULTS:A complete echocardiographic study and blood sampling were performed in 65 consecutive stable IDCM pat...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfq057

    authors: Kontaraki JE,Parthenakis FI,Nyktari EG,Patrianakos AP,Vardas PE

    更新日期:2010-06-01 00:00:00

  • Evaluation of kidney function throughout the heart failure trajectory - a position statement from the Heart Failure Association of the European Society of Cardiology.

    abstract::Appropriate interpretation of changes in markers of kidney function is essential during the treatment of acute and chronic heart failure. Historically, kidney function was primarily assessed by serum creatinine and the calculation of estimated glomerular filtration rate. An increase in serum creatinine, also termed wo...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.1697

    authors: Mullens W,Damman K,Testani JM,Martens P,Mueller C,Lassus J,Tang WHW,Skouri H,Verbrugge FH,Orso F,Hill L,Ural D,Lainscak M,Rossignol P,Metra M,Mebazaa A,Seferovic P,Ruschitzka F,Coats A

    更新日期:2020-04-01 00:00:00

  • Relation of atrial natriuretic peptides to left ventricular systolic and diastolic function in heart failure.

    abstract:BACKGROUND:Plasma concentrations of atrial natriuretic peptides are correlated with atrial pressures, as are left ventricular ejection fraction and left ventricular filling abnormalities. AIMS:This study investigated the relation of atrial natriuretic peptides to both left ventricular systolic and diastolic function i...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(98)00005-1

    authors: Wijbenga AA,Balk AH,Jonkman FA,Boomsma F,Simoons ML,Man in t Veld AJ

    更新日期:1999-03-01 00:00:00