Abstract：
AIMS:Aldosterone activation is central to the sodium–fluid retention that marks the progression of heart failure (HF). The actions of dietary sodium restriction, a mainstay in HF management, on cardiorenal and neuroendocrine adaptations during the progression of HF are poorly understood. The study aim was to assess the role of dietary sodium during the progression of experimental HF. METHODS AND RESULTS:Experimental HF was produced in a canine model by rapid right ventricular pacing which evolves from early mild HF to overt, severe HF. Dogs were fed one of three diets: (i) high sodium [250 mEq (5.8 g) per day, n =6]; (ii) standard sodium [58 mEq (1.3 g) per day, n =6]; and (iii) sodium restriction [11 mEq (0.25 g) per day, n =6]. During the 38-day study, haemodynamics, renal function, plasma renin activity (PRA), and aldosterone were measured. Changes in haemodynamics at 38 days were similar in all three groups, as were changes in renal function. Aldosterone activation was demonstrated in all three groups; however, dietary sodium restriction, in contrast to high sodium, resulted in early (10 days) activation of PRA and aldosterone. High sodium demonstrated significant suppression of aldosterone activation over the course of HF progression. CONCLUSIONS:Excessive dietary sodium restriction particularly in early stage HF results in early aldosterone activation, while normal and excess sodium intake are associated with delayed or suppressed activation. These findings warrant evaluation in humans to determine if dietary sodium manipulation, particularly during early stage HF, may have a significant impact on neuroendocrine disease progression.
journal_name
Eur J Heart Failjournal_title
European journal of heart failureauthors
Miller WL,Borgeson DD,Grantham JA,Luchner A,Redfield MM,Burnett JC Jrdoi
10.1002/ejhf.212subject
Has Abstractpub_date
2015-02-01 00:00:00pages
144-50issue
2eissn
1388-9842issn
1879-0844journal_volume
17pub_type
杂志文章abstract：BACKGROUND:Echocardiography with Doppler examination of the aortic valve provides a very accurate assessment of the transvalvular gradient and is used to monitor progression of aortic stenosis (AS). Plasma brain natriuretic peptide (BNP) has been shown to correlate with end-systolic wall stress in patients with AS. AI...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/s1388-9842(00)00074-x
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:In most animal models of chronic hemodynamic overload of the left ventricle (LV) as well as in human end stage heart failure, the sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA2a) mRNA levels are decreased in parallel with increased atrial natriuretic peptide (ANP) mRNA levels. The situation in the remote my...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/j.ejheart.2004.10.007
更新日期：2005-08-01 00:00:00
abstract：AIMS:We sought to test the utility of weight gain algorithms to predict episodes of worsening heart failure (WHF) using home-telemonitoring data collected as part of the TEN-HMS study. METHODS AND RESULTS:Simple rule-of-thumb (RoT) algorithms (i.e. 3 lbs in 1 day and 5 lbs in 3 days) and a moving average convergence d...
journal_title：European journal of heart failure
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1093/eurjhf/hfp033
更新日期：2009-04-01 00:00:00
abstract：AIMS:Scarce data are available on the effect of the traditional Mediterranean diet (TMD) on heart failure biomarkers. We assessed the effect of TMD on biomarkers related to heart failure in a high cardiovascular disease risk population. METHODS AND RESULTS:A total of 930 subjects at high cardiovascular risk (420 men a...
journal_title：European journal of heart failure
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1002/ejhf.61
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:Supervised cardiac rehabilitation programs have been offered to patients following myocardial infarct (MI), coronary artery bypass graft surgery (CABG) and percutaneous coronary intervention (PCI) for many years. However, limited information is available on the usefulness of rehabilitation programs in chroni...
journal_title：European journal of heart failure
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ejheart.2005.05.002
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:Chronic heart failure (CHF) is common and is frequently managed by primary care physicians (PCPs). Despite the European Society of Cardiology (ESC) Guidelines, standard treatments for CHF are frequently underutilised, particularly in primary care. AIM:To evaluate current drug therapy for CHF in adults with ...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/j.ejheart.2004.09.003
更新日期：2004-10-01 00:00:00
abstract：BACKGROUND:It has been suggested that oxidative stress may play a role in the pathogenesis of heart failure, this may have potential implications for therapeutic strategies. However, measures of oxidative stress are subject to confounding inaccuracies. IgG antibodies to oxidized LDL reflect exposure to the lipoprotein ...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/j.ejheart.2005.04.015
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:The association between serum digoxin concentration (SDC) and outcomes in women with heart failure (HF) has not been well studied. AIMS:To test the hypothesis that the effect of digoxin on outcomes in women with HF is bi-directional and dependent on SDC, as in men, and is modified by ejection fraction (EF)....
journal_title：European journal of heart failure
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ejheart.2005.10.002
更新日期：2006-06-01 00:00:00
abstract：AIMS:The goal of the study was to examine the prognostic impact, haemodynamic and clinical features associated with lung congestion in patients with chronic heart failure (HF). METHODS AND RESULTS:HF patients (n = 186) and HF-free controls (n = 21) underwent right heart catheterization, echocardiography, pulmonary fun...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1002/ejhf.417
更新日期：2015-11-01 00:00:00
abstract：AIMS:The 'Hospital at home' (HaH) model avoids hospital admission by transferring healthcare and treatment to the patient's home. We aimed to compare the effectiveness and direct healthcare costs of treating elderly patients with decompensated heart failure (HF) using HaH care vs. inpatient hospital care (IHC) in a car...
journal_title：European journal of heart failure
pub_type： 杂志文章,随机对照试验
doi：10.1093/eurjhf/hfp143
更新日期：2009-12-01 00:00:00
abstract：BACKGROUND:Recent advances in pharmacological and pacemaker-based treatments for heart failure (HF) have brought about significant improvements in left ventricular function. AIMS:To identify the proportion of treated systolic HF patients in whom left ventricular systolic function improves and/or returns to normal. ME...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/j.ejheart.2007.10.001
更新日期：2007-12-01 00:00:00
abstract：AIMS:Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) is a strong biochemical marker of heart failure and left ventricular dysfunction (LVD). Due to renal arterio-venous clearance of NT-proBNP and the correlation of plasma concentrations with renal function, we hypothesized that NT-proBNP may have potential ...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1093/eurjhf/hfq016
更新日期：2010-04-01 00:00:00
abstract：AIMS:To examine the impact of diabetes mellitus on long-term clinical outcomes in patients with myocardial infarction (MI) complicated by clinical signs of heart failure (HF) or left ventricular dysfunction (LVD). METHODS AND RESULTS:The High-Risk MI Database consists of individual data from 28 771 patients and was cr...
journal_title：European journal of heart failure
pub_type： 杂志文章,多中心研究
doi：10.1002/ejhf.797
更新日期：2017-05-01 00:00:00
abstract：BACKGROUND:Coronary artery disease (CAD) is frequent among patients hospitalized with acute heart failure syndromes (AHFS). AIMS:To describe the influence of coronary revascularization status on survival in patients with AHFS. METHODS AND RESULTS:OPTIMIZE-HF enrolled 48,612 patients with AHFS from 259 U.S. hospitals....
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/j.ejheart.2008.09.009
更新日期：2008-12-01 00:00:00
abstract：AIMS:To evaluate right-ventricular (RV) function during stress echocardiography (SE) and to assess its relationship with exercise capacity in heart failure (HF) patients. METHODS AND RESULTS:We included 88 patients aged 60.9 +/- 11.2 years with a mean LVEF of 27.2 +/- 9.5%. The following RV parameters were measured at...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1093/eurjhf/hfp200
更新日期：2010-03-01 00:00:00
abstract：OBJECTIVE:Infused C-type natriuretic peptide (CNP) was recently found to play a cardioprotective role in preventing myocardial ischaemia/reperfusion (I/R) injury and improving cardiac remodelling after myocardial infarction (MI) in rats. Our study aimed to investigate the effect of cardiomyocyte-specific CNP over-expre...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/j.ejheart.2007.02.006
更新日期：2007-06-01 00:00:00
abstract：:Heart failure and sleep apnoea are major health problems with an increasingly recognized association; evidence suggests that sleep apnoea may play a role in the progression of heart failure. However, confounding factors such as obesity, hypertension and coronary heart disease make this relationship uncertain and an in...
journal_title：European journal of heart failure
pub_type： 杂志文章,评审
doi：10.1016/j.ejheart.2005.07.013
更新日期：2006-05-01 00:00:00
abstract：:Patients with chronic coronary heart disease often suffer from congestive heart failure (CHF) despite multiple drug therapies. D-Ribose has been shown in animal models to improve cardiac energy metabolism and function following ischaemia. This was a prospective, double blind, randomized, crossover design study, to ass...
journal_title：European journal of heart failure
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s1388-9842(03)00060-6
更新日期：2003-10-01 00:00:00
abstract：AIMS:To test the hypothesis that an earlier post-acute myocardial infarction (AMI) eplerenone initiation in patients with left ventricular systolic dysfunction (LVSD) and heart failure (HF) is associated with better long-term outcomes. METHODS AND RESULTS:The 6632 patients of the EPHESUS study were randomized from day...
journal_title：European journal of heart failure
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1093/eurjhf/hfp136
更新日期：2009-11-01 00:00:00
abstract：AIMS:Although pulse pressure (PP) is a recognized risk factor for various cardiovascular diseases, its association with cardiovascular outcomes in patients with heart failure with preserved ejection fraction (HFpEF) is uncertain. METHODS AND RESULTS:We enrolled 512 of 951 consecutive HFpEF patients admitted to the Kum...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1002/ejhf.559
更新日期：2016-11-01 00:00:00
abstract：AIM:Mineralocorticoid receptor antagonists (MRAs) improve outcomes in heart failure with reduced ejection fraction (HFrEF), but are underutilized. Hyperkalaemia may be one reason, but the underlying reasons for underuse are unknown. The aim of this study was to investigate the independent predictors of MRA underuse in ...
journal_title：European journal of heart failure
pub_type： 杂志文章,多中心研究,评审
doi：10.1002/ejhf.1182
更新日期：2018-09-01 00:00:00
abstract：AIMS:Remote patient management (telemonitoring) may help to detect early signs of cardiac decompensation, allowing optimization of and adherence to treatments in chronic heart failure (CHF). Two meta-analyses have suggested that telemedicine in CHF can reduce mortality by 30-35%. The aim of the TIM-HF study was to inve...
journal_title：European journal of heart failure
pub_type： 杂志文章,随机对照试验
doi：10.1093/eurjhf/hfq199
更新日期：2010-12-01 00:00:00
abstract：AIMS:To assess the tolerability of initiating/uptitrating sacubitril/valsartan (LCZ696) from 50 to 200 mg twice daily (target dose) over 3 and 6 weeks in heart failure (HF) patients (ejection fraction ≤35%). METHODS AND RESULTS:A 5-day open-label run-in (sacubitril/valsartan 50 mg twice daily) preceded an 11-week, dou...
journal_title：European journal of heart failure
pub_type： 杂志文章,随机对照试验
doi：10.1002/ejhf.548
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Bifocal pacing (BFP) has been proposed as a feasible alternative to cardiac resynchronization therapy. AIM:To evaluate BFP in patients with severe heart failure and significant intraventricular conduction delay and to compare it with biventricular pacing (BVP). METHODS:Echocardiographic examination includi...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/j.ejheart.2006.09.003
更新日期：2007-03-01 00:00:00
abstract：:Patients with mild-moderate chronic heart failure (CHF) often have raised levels of serum uric acid (UA). This is due, amongst other factors, to reduced UA excretion by the kidneys, which is partly explained by restriction of sodium intake and treatment with diuretics. The decline in renal function that parallels wors...
journal_title：European journal of heart failure
pub_type： 杂志文章,评审
doi：10.1016/j.ejheart.2004.03.020
更新日期：2005-06-01 00:00:00
abstract：:We investigated the hypothesis that increased intracellular [Na+]i in heart failure contributes to preservation of SR Ca2+ load which may become particularly evident at slow heart rates. [Na+]i in SBFI-loaded myocytes from rabbits with pacing-induced heart failure (PHF) was significantly higher at each frequency as co...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/j.ejheart.2006.01.013
更新日期：2006-11-01 00:00:00
abstract：AIMS:Acute heart failure is a high mortality disease and its pathophysiology is not completely understood. Dipeptidyl peptidase 3 (DPP3) is a cytosolic enzyme involved in angiotensin II and enkephalins cleavage. The aim of this study was to investigate the association of circulating DPP3 (cDPP3) levels and mortality in...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1002/ejhf.1601
更新日期：2020-02-01 00:00:00
abstract：AIMS:Left ventricular contractile reserve is a prognostic indicator for adverse outcome in patients with severe chronic heart failure with reduced ejection fraction (HFrEF). We investigated the dobutamine-induced changes of LV multidimensional deformation and their predictive value for cardiac mortality of patients wit...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1002/ejhf.787
更新日期：2017-07-01 00:00:00
abstract：BACKGROUND:The incidence of ventricular tachyarrhythmias in ICD patients with cardiac resynchronisation therapy (CRT-D) is not well studied. AIM:To analyse event free survival in CRT-D patients with a primary or a secondary prophylactic ICD indication. METHODS:Prospective, single centre. Eighty-six patients, 44% with...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/j.ejheart.2005.05.006
更新日期：2005-10-01 00:00:00
abstract：BACKGROUND:Hereditary hemochromatosis (HH), a common autosomal recessive disease, leads to excessive iron accumulation in some organs, including the heart. It is therefore not surprising that cardiomyopathy is one of the most severe complications of HH. The HFE gene defects have been thought to contribute to idiopathic...
journal_title：European journal of heart failure
pub_type： 杂志文章
doi：10.1016/j.ejheart.2004.03.007
更新日期：2005-01-01 00:00:00
