N-terminal pro-brain natriuretic peptide from fresh urine for the biochemical detection of heart failure and left ventricular dysfunction.

Abstract:

AIMS:Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) is a strong biochemical marker of heart failure and left ventricular dysfunction (LVD). Due to renal arterio-venous clearance of NT-proBNP and the correlation of plasma concentrations with renal function, we hypothesized that NT-proBNP may have potential as a urinary marker. The objective of this study was to assess urinary concentrations of NT-proBNP and to identify the predictive value of urinary NT-proBNP for detecting LVD and heart failure. METHODS AND RESULTS:N-terminal pro-brain natriuretic peptide (Elecsys proBNP((R)), Roche) was assessed simultaneously in fresh spot urine and plasma from 191 individuals. In patients with heart failure (n = 149), urinary and plasma NT-proBNP concentrations were positively correlated (r = 0.79, P < 0.001), but urinary NT-proBNP was significantly lower than plasma NT-proBNP (42 +/- 25 vs. 1389 +/- 325 pg/mL, P < 0.001). Upon receiver operating curve analysis, urinary NT-proBNP detected LV dysfunction (ejection fraction <40%) with a sensitivity of 91% and a specificity of 98% at a cutpoint of 22 pg/mL [area under the curves (AUC) 0.98]. At the same cutpoint, symptomatic heart failure (NYHA-class > 2) was detected with a sensitivity of 97% and specificity of 98% (AUC 0.99) and clinical signs of fluid retention were detected with a sensitivity and specificity of 98% each (AUC 0.99). CONCLUSION:N-terminal pro-brain natriuretic peptide concentrations were markedly lower in the urine than in the plasma. However, urinary NT-proBNP levels increased stepwise with the severity of heart failure and LVD, and therefore yielded satisfactory predictive values for the detection of significant LVD and symptomatic heart failure. Measurement of urinary NT-proBNP is a novel, promising, and simple method for the biochemical detection of heart failure.

journal_name

Eur J Heart Fail

authors

Jungbauer CG,Buchner S,Birner C,Resch M,Heinicke N,Debl K,Buesing M,Biermeier D,Schmitz G,Riegger G,Luchner A

doi

10.1093/eurjhf/hfq016

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

331-7

issue

4

eissn

1388-9842

issn

1879-0844

pii

hfq016

journal_volume

12

pub_type

杂志文章
  • Aetiology, comorbidity and drug therapy of chronic heart failure in the real world: the EPICA substudy.

    abstract:BACKGROUND:Chronic heart failure (CHF) is common and is frequently managed by primary care physicians (PCPs). Despite the European Society of Cardiology (ESC) Guidelines, standard treatments for CHF are frequently underutilised, particularly in primary care. AIM:To evaluate current drug therapy for CHF in adults with ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2004.09.003

    authors: Ceia F,Fonseca C,Mota T,Morais H,Matias F,Costa C,Oliveira AG

    更新日期:2004-10-01 00:00:00

  • Severe anaemia and subcapital femur fracture in a patient with Left Ventricular Assist Device Heart Mate II: the cardiologist's management of this rare patient.

    abstract::The use of Left Ventricular Assist Devices (LVADs) has increased over the last decade because of the lack of healthy donor hearts. In this report we describe for the first time a patient with an LVAD Heart Mate II (HM II) implanted 6 months before admission, who initially suffered from severe anaemia and later on unde...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfp090

    authors: Gogas BD,Parissis JT,Filippatos GS,Iliodromitis EK,Soultanis KC,Kostopanagiotou GG,Theodoropoulos SP,Kremastinos DT,Yacoub MH

    更新日期:2009-08-01 00:00:00

  • Prognostic importance of exercise brain natriuretic peptide in asymptomatic degenerative mitral regurgitation.

    abstract:AIM:The exercise Doppler echocardiographic stress test can be of interest in the management of asymptomatic patients with primary mitral regurgitation (MR). The resting brain natriuretic peptide (BNP) level is a good surrogate marker of the consequences of MR and is a powerful predictor of outcome. The incremental prog...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfs114

    authors: Magne J,Mahjoub H,Pibarot P,Pirlet C,Pierard LA,Lancellotti P

    更新日期:2012-11-01 00:00:00

  • Characteristics, outcomes, and predictors of mortality at 3 months and 1 year in patients hospitalized for acute heart failure.

    abstract:AIMS:Acute heart failure (AHF) has a poor prognosis. We evaluated 3- and 12-month mortality in different clinical classes of AHF patients from 30 European countries who were included in the EuroHeart Failure Survey (EHFS) II. METHODS AND RESULTS:Follow-up data were available for 2981 AHF patients, of these 62% had a h...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurjhf/hfq002

    authors: Harjola VP,Follath F,Nieminen MS,Brutsaert D,Dickstein K,Drexler H,Hochadel M,Komajda M,Lopez-Sendon JL,Ponikowski P,Tavazzi L

    更新日期:2010-03-01 00:00:00

  • High prevalence of subclinical cerebral infarction in patients with heart failure with preserved ejection fraction.

    abstract:AIMS:Undetected atrial fibrillation (AF) may be common in the heart failure with preserved ejection fraction (HFpEF) population, and failure to detect this may lead to the missing of opportunities to prevent associated subclinical cerebral infarctions (SCIs) and cognitive decline. METHODS AND RESULTS:We studied 1527 p...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.812

    authors: Cogswell RJ,Norby FL,Gottesman RF,Chen LY,Solomon S,Shah A,Alonso A

    更新日期:2017-10-01 00:00:00

  • Connecting heart failure with preserved ejection fraction and renal dysfunction: the role of endothelial dysfunction and inflammation.

    abstract::Renal dysfunction in heart failure with preserved ejection fraction (HFpEF) is common and is associated with increased mortality. Impaired renal function is also a risk factor for developing HFpEF. A new paradigm for HFpEF, proposing a sequence of events leading to myocardial remodelling and dysfunction in HFpEF, was ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1002/ejhf.497

    authors: Ter Maaten JM,Damman K,Verhaar MC,Paulus WJ,Duncker DJ,Cheng C,van Heerebeek L,Hillege HL,Lam CS,Navis G,Voors AA

    更新日期:2016-06-01 00:00:00

  • Predicting hospitalization due to worsening heart failure using daily weight measurement: analysis of the Trans-European Network-Home-Care Management System (TEN-HMS) study.

    abstract:AIMS:We sought to test the utility of weight gain algorithms to predict episodes of worsening heart failure (WHF) using home-telemonitoring data collected as part of the TEN-HMS study. METHODS AND RESULTS:Simple rule-of-thumb (RoT) algorithms (i.e. 3 lbs in 1 day and 5 lbs in 3 days) and a moving average convergence d...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurjhf/hfp033

    authors: Zhang J,Goode KM,Cuddihy PE,Cleland JG,TEN-HMS Investigators.

    更新日期:2009-04-01 00:00:00

  • The role of plasma biomarkers in acute heart failure. Serial changes and independent prognostic value of NT-proBNP and cardiac troponin-T.

    abstract:AIMS:Brain natriuretic peptide (BNP), NT-proBNP and troponins are useful for the assessment of patients with heart failure. Few data exist about their serial changes and their prognostic value in patients with acute heart failure (AHF). METHODS AND RESULTS:NT-proBNP and troponin-T plasma levels were measured at baseli...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2007.05.007

    authors: Metra M,Nodari S,Parrinello G,Specchia C,Brentana L,Rocca P,Fracassi F,Bordonali T,Milani P,Danesi R,Verzura G,Chiari E,Dei Cas L

    更新日期:2007-08-01 00:00:00

  • Ambulatory blood pressure monitoring in heart failure: a systematic review.

    abstract::Ambulatory blood pressure monitoring has established its use in the definition of white coat hypertension and monitoring of treatment of essential hypertension. Any role for ambulatory blood pressure monitoring in heart failure is not well defined. However, from the limited studies available, ambulatory blood pressure...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejheart.2004.05.010

    authors: Goyal D,Macfadyen RJ,Watson RD,Lip GY

    更新日期:2005-03-02 00:00:00

  • Preferences of heart failure patients in daily clinical practice: quality of life or longevity?

    abstract:AIMS:Knowledge of patient preferences is vital for delivering optimal healthcare. This study uses utility measurement to assess the preferences of heart failure (HF) patients regarding quality of life or longevity. The utility approach represents the perspective of a patient; facilitates the combination of mortality, m...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hft071

    authors: Kraai IH,Vermeulen KM,Luttik ML,Hoekstra T,Jaarsma T,Hillege HL

    更新日期:2013-10-01 00:00:00

  • Heart failure in a multiethnic population in Kuala Lumpur, Malaysia.

    abstract:BACKGROUND:There are established differences in cardiovascular disease in different racial groups. Worldwide, the literature regarding the clinical epidemiology of congestive heart failure (CHF) in non-white populations is scarce. OBJECTIVES:To document the prevalence of CHF in the multiracial population of Malaysia, ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(03)00013-8

    authors: Chong AY,Rajaratnam R,Hussein NR,Lip GY

    更新日期:2003-08-01 00:00:00

  • Effect of warfarin on survival in patients with concomitant left ventricular systolic dysfunction and pulmonary hypertension: a population cohort study.

    abstract:BACKGROUND:The use of oral anticoagulation in patients with heart failure in sinus rhythm remains controversial as previous large randomized controlled trials (RCTs) have not shown a survival benefit. However, heterogeneity exists among heart failure patients and it is possible that high-risk subgroups may benefit from...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.199

    authors: Goudie A,Elder D,Deshmukh H,Szwejkowski BR,Lang CC,George J

    更新日期:2015-01-01 00:00:00

  • Efficacy of a homeopathic Crataegus preparation compared with usual therapy for mild (NYHA II) cardiac insufficiency: results of an observational cohort study.

    abstract:OBJECTIVES:To compare the efficacy of the homeopathic Crataegus preparation Cralonin for non-inferiority to standard treatment for mild cardiac insufficiency. METHODS:Multicentre non-randomised cohort study in patients aged 50-75 years in New York Heart Association class II. Patients received Cralonin (n=110) or ACE i...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究

    doi:10.1016/s1388-9842(02)00237-4

    authors: Schröder D,Weiser M,Klein P

    更新日期:2003-06-01 00:00:00

  • Desmin accumulation restrictive cardiomyopathy and atrioventricular block associated with desmin gene defects.

    abstract:BACKGROUND:Primary desminopathies are caused by desmin gene [DES (MIM*125660)] mutations. The clinical spectrum includes pure myopathies, cardiomuscular diseases and cardiomyopathies. Patients with restrictive cardiomyopathy (RCM) plus atrioventricular block (AVB) due to DES defects are frequently unrecognized unless d...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2005.11.003

    authors: Arbustini E,Pasotti M,Pilotto A,Pellegrini C,Grasso M,Previtali S,Repetto A,Bellini O,Azan G,Scaffino M,Campana C,Piccolo G,Viganò M,Tavazzi L

    更新日期:2006-08-01 00:00:00

  • Self-rating of quality of life provides additional prognostic information in heart failure. Insights into the EPICAL study.

    abstract:BACKGROUND:The relationship between quality of life (QoL) and survival have been poorly investigated. The aim of this study was to determine the value of QoL score as a prognostic factor in a prospective cohort of patients with advanced chronic heart failure (CHF). METHODS:QoL assessment was performed with a generic q...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(02)00006-5

    authors: Alla F,Briançon S,Guillemin F,Juillière Y,Mertès PM,Villemot JP,Zannad F,EPICAL Investigators.

    更新日期:2002-06-01 00:00:00

  • Viewpoint: the prothrombotic state in heart failure: a maladaptive inflammatory response?

    abstract::Patients with heart failure (HF) are at an increased risk of stroke, sudden death and venous thromboembolism, which are all linked to thrombus formation (thrombogenesis). The present 'viewpoint' article will discuss how the prothrombotic state in HF may be perpetuated by a chronic inflammatory state that is maladaptiv...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejheart.2006.05.009

    authors: Chong AY,Lip GY

    更新日期:2007-02-01 00:00:00

  • Prognostic significance of tricuspid annular motion and plasma NT-proBNP in patients with heart failure and moderate-to-severe functional mitral regurgitation.

    abstract:BACKGROUND:The role of the right ventricle has been relatively neglected proportionate to its importance. We sought to evaluate the impact of right ventricular (RV) and NT-proBNP on the outcome of patients with heart failure (HF) and functional mitral regurgitation (MR). METHODS AND PATIENTS:Outpatients with left vent...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2008.04.003

    authors: Dini FL,Fontanive P,Panicucci E,Andreini D,Chella P,De Tommasi SM

    更新日期:2008-06-01 00:00:00

  • Effects of applying a standardised management algorithm for moderate to severe renal dysfunction in patients with chronic stable heart failure.

    abstract:BACKGROUND:No specific guidelines exist on how to manage renal dysfunction (RD) in patients with chronic heart failure (CHF). AIMS:To identify the proportion of patients with moderate to severe RD and CHF who showed an improvement in their renal function in response to a systematic management algorithm. METHODS:Stabl...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2006.10.003

    authors: de Silva R,Nikitin NP,Witte KK,Rigby AS,Loh H,Nicholson A,Bhandari S,Clark AL,Cleland JG

    更新日期:2007-04-01 00:00:00

  • Natriuretic peptides and echocardiography in acute dyspnoea: implication of elevated levels with normal systolic function.

    abstract:AIMS:Previous evaluations of natriuretic peptide (NP) levels in patients with acute dyspnoea presenting to the emergency department (ED) have selected only a minority of patients for echocardiography. We aimed to evaluate the association between NPs and more subtle echocardiographic findings and to assess the potential...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurjhf/hfp075

    authors: Shah KB,Kop WJ,Christenson RH,Diercks DB,Kuo D,Henderson S,Hanson K,Li SY,deFilippi CR

    更新日期:2009-07-01 00:00:00

  • Sex-specific cardiovascular structure and function in heart failure with preserved ejection fraction.

    abstract:AIMS:Women are more likely to develop heart failure with preserved ejection fraction (HFpEF) than men. We studied the relationship between sex and cardiovascular structure and function in patients with HFpEF. METHODS AND RESULTS:The study included 279 participants from the PARAMOUNT study (57% women) with analysable b...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.67

    authors: Gori M,Lam CS,Gupta DK,Santos AB,Cheng S,Shah AM,Claggett B,Zile MR,Kraigher-Krainer E,Pieske B,Voors AA,Packer M,Bransford T,Lefkowitz M,McMurray JJ,Solomon SD,PARAMOUNT Investigators.

    更新日期:2014-05-01 00:00:00

  • Angiotensin II subtype 1 (AT1) receptors contribute to ischemic contracture and regulate chemomechanical energy transduction in isolated transgenic rat (alphaMHC-hAT1)594-17 hearts.

    abstract:BACKGROUND:The role of AT1 receptors in myocardial ischemia/reperfusion injury is unclear. We, therefore, investigated the effects of the AT1 receptor antagonist irbesartan (Irb) in isolated hearts of selective myocardial AT1 overexpressing transgenic [transgenic(alphaMHC-hAT1)594-17] and Sprague-Dawley rats (SD) subje...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(02)00005-3

    authors: Han H,Hoffmann S,Hu K,Ertl G

    更新日期:2002-03-01 00:00:00

  • Prevalence and aetiology of heart failure in an Arab population.

    abstract:BACKGROUND:The epidemiology of heart failure in Arabia, with a population different from the West in cultural and ethnic origin, has not been studied before. AIMS:To determine the prevalence and aetiologies of symptomatic heart failure in an indigenous Arab population over a 3-year period. METHODS:All patients with h...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(00)00149-5

    authors: Agarwal AK,Venugopalan P,de Bono D

    更新日期:2001-06-01 00:00:00

  • Factors associated with underuse of mineralocorticoid receptor antagonists in heart failure with reduced ejection fraction: an analysis of 11 215 patients from the Swedish Heart Failure Registry.

    abstract:AIM:Mineralocorticoid receptor antagonists (MRAs) improve outcomes in heart failure with reduced ejection fraction (HFrEF), but are underutilized. Hyperkalaemia may be one reason, but the underlying reasons for underuse are unknown. The aim of this study was to investigate the independent predictors of MRA underuse in ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究,评审

    doi:10.1002/ejhf.1182

    authors: Savarese G,Carrero JJ,Pitt B,Anker SD,Rosano GMC,Dahlström U,Lund LH

    更新日期:2018-09-01 00:00:00

  • Increasing glucose levels and BMI predict future heart failure experience from the Reykjavík Study.

    abstract:BACKGROUND:Heart failure is common in diabetes and ischaemic heart disease is the most likely link. Still, it has been suggested that the relation extends beyond such disease. METHODS:7060 subjects with two or more visits in the Reykjavík Study were followed--during 30 years from 1967. All underwent oral glucose toler...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2007.07.017

    authors: Thrainsdottir IS,Aspelund T,Gudnason V,Malmberg K,Sigurdsson G,Thorgeirsson G,Hardarson T,Rydén L

    更新日期:2007-10-01 00:00:00

  • Insights into the importance of the electrocardiogram in patients with acute heart failure.

    abstract:BACKGROUND:Patients presenting to the emergency department (ED) with acute heart failure (AHF) are at an increased risk of morbidity and mortality. The electrocardiogram (ECG) is a routine investigation in patients with AHF used to identify potential causes and/or complications. It is unclear whether 12-lead ECG charac...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.561

    authors: Gouda P,Brown P,Rowe BH,McAlister FA,Ezekowitz JA

    更新日期:2016-08-01 00:00:00

  • Heart failure with normal ejection fraction is uncommon in acute myocardial infarction settings but associated with poor outcomes: a study of 91,360 patients admitted with index myocardial infarction between 1998 and 2010.

    abstract:AIM:Data are scant on the incidence and prognosis of heart failure (HF) with normal ejection fraction (HFNEF, EF >49%) in an acute myocardial infarction (AMI) setting. The aim of this study was to examine incidence and predictors of HFNEF during an index acute myocardial infarction (AMI) and its subsequent associations...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.416

    authors: Desta L,Jernberg T,Spaak J,Hofman-Bang C,Persson H

    更新日期:2016-01-01 00:00:00

  • Alveolar-capillary membrane conductance is the best pulmonary function correlate of exercise ventilation efficiency in heart failure patients.

    abstract:BACKGROUND:In heart failure (HF), changes in lung mechanics and gas diffusion are limiting factors to exercise. Their contribution to an increased exercise ventilation to CO2 production (VE/VCO2) slope is undefined. METHODS:A total of 67 stable HF patients underwent cardiopulmonary exercise and pulmonary function test...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2004.10.009

    authors: Guazzi M,Reina G,Tumminello G,Guazzi MD

    更新日期:2005-10-01 00:00:00

  • Clinical picture and risk prediction of short-term mortality in cardiogenic shock.

    abstract:AIMS:The aim of this study was to investigate the clinical picture and outcome of cardiogenic shock and to develop a risk prediction score for short-term mortality. METHODS AND RESULTS:The CardShock study was a multicentre, prospective, observational study conducted between 2010 and 2012. Patients with either acute co...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ejhf.260

    authors: Harjola VP,Lassus J,Sionis A,Køber L,Tarvasmäki T,Spinar J,Parissis J,Banaszewski M,Silva-Cardoso J,Carubelli V,Di Somma S,Tolppanen H,Zeymer U,Thiele H,Nieminen MS,Mebazaa A,CardShock Study Investigators.,GREAT network

    更新日期:2015-05-01 00:00:00

  • Short-term effects of sinus rhythm restoration in patients with lone atrial fibrillation: a hormonal study.

    abstract::It is well known that atrial fibrillation can lead to heart failure, and is attributed to rapid ventricular rate (tachycardia-induced cardiomyopathy). Some recent studies suggest the possible existence of an intrinsic left-ventricular factor related to atrial fibrillation, irrespective of other elements. In order to d...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(02)00004-1

    authors: Jourdain P,Bellorini M,Funck F,Fulla Y,Guillard N,Loiret J,Thebault B,Sadeg N,Desnos M

    更新日期:2002-06-01 00:00:00

  • Simultaneous angiotensin converting enzyme inhibition moderates ventricular dysfunction caused by doxorubicin.

    abstract:AIMS:The purpose of this study was to determine that the administration of an angiotensin converting enzyme (ACE) inhibitor enalapril would confer protection against doxorubicin-induced experimental heart failure, and attenuate the development of left ventricular dysfunction. METHODS:Seventeen dogs were chronically in...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(02)00091-0

    authors: Vaynblat M,Shah HR,Bhaskaran D,Ramdev G,Davis WJ 3rd,Cunningham JN Jr,Chiavarelli M

    更新日期:2002-10-01 00:00:00