Connecting heart failure with preserved ejection fraction and renal dysfunction: the role of endothelial dysfunction and inflammation.

abstract：:Transthyretin amyloidosis (ATTR) is a rare, yet underdiagnosed disease characterized by progressive impairment of neurologic and cardiac function due to deposition of misfolded transthyretin. Despite great efforts, such as the introduction of orthotopic liver transplant, the devastating prognosis for both variant and ...

journal_title：European journal of heart failure

authors： Müller ML,Butler J,Heidecker B

更新日期：2020-01-01 00:00:00

abstract：AIMS:To determine the association between obesity and outcomes in post-acute myocardial infarction (AMI) patients with systolic heart failure (HF). METHODS AND RESULTS:Of the 6632 Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) participants, 6611 had data on baseline bod...

journal_title：European journal of heart failure

authors： Wu AH,Pitt B,Anker SD,Vincent J,Mujib M,Ahmed A

更新日期：2010-06-01 00:00:00

abstract：AIMS:As pulmonary arterial hypertension (PAH) is associated with significant morbidity and mortality, particularly among patients with right ventricular (RV) dysfunction, we aimed to determine the impact of therapy to reduce pulmonary vascular resistance (PVR) on RV and LV deformation in PAH. METHODS AND RESULTS:Right...

journal_title：European journal of heart failure

authors： Querejeta Roca G,Campbell P,Claggett B,Vazir A,Quinn D,Solomon SD,Shah AM

更新日期：2015-01-01 00:00:00

abstract：AIMS:A recent study suggested that no single echocardiographic index of cardiac dyssynchrony can reliably identify candidates for cardiac resynchronization therapy (CRT). We examined the value of three simple echocardiographic indices for predicting the 6-month clinical and echocardiographic responses to CRT. METHODS ...

journal_title：European journal of heart failure

authors： Bordachar P,Lafitte S,Réant P,Reuter S,Clementy J,Mletzko RU,Siegel RM,Goscinska-Bis K,Bowes R,Morgan J,Bénard S,Leclercq C

更新日期：2010-06-01 00:00:00

abstract：AIMS:Despite improvement in prognosis for ST-elevation myocardial infarction (STEMI) patients, mortality remains high in STEMI patients presenting with cardiogenic shock (CS). Right ventricular (RV) dysfunction is an established independent predictor for adverse prognosis in STEMI patients without CS. The purpose of ou...

journal_title：European journal of heart failure

authors： Engström AE,Vis MM,Bouma BJ,van den Brink RB,Baan J Jr,Claessen BE,Kikkert WJ,Sjauw KD,Meuwissen M,Koch KT,de Winter RJ,Tijssen JG,Piek JJ,Henriques JP

更新日期：2010-03-01 00:00:00

abstract：AIMS:Peripheral muscle dysfunction is a key mechanism contributing to exercise intolerance (i.e. breathlessness and fatigue) in heart failure patients with preserved ejection fraction (HFpEF); however, the underlying molecular and cellular mechanisms remain unknown. We therefore used an animal model to elucidate potent...

journal_title：European journal of heart failure

authors： Bowen TS,Rolim NP,Fischer T,Baekkerud FH,Medeiros A,Werner S,Brønstad E,Rognmo O,Mangner N,Linke A,Schuler G,Silva GJ,Wisløff U,Adams V,Optimex Study Group.

更新日期：2015-03-01 00:00:00

abstract：UNLABELLED:Experimental data have shown that rIL2 has negative inotropic properties. This has not been investigated in humans with normal left ventricular function. Seventeen consecutive renal cell carcinoma patients who received rIL2 therapy because of dissemination were analyzed before and after treatment with a low ...

journal_title：European journal of heart failure

authors： Tio RA,Nieken J,de Vries EG,Pfeiffer C,de Jongste MJ,Pieper E,Moshage H,Limburg PC,Mulder NH

更新日期：2000-06-01 00:00:00

abstract：AIMS:Several studies have shown that older patients with heart failure with reduced ejection fraction (HFrEF) are undertreated. The aim of this study was to evaluate the association of up-titration of angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB) and beta-blockers on outcome acros...

journal_title：European journal of heart failure

authors： Mordi IR,Ouwerkerk W,Anker SD,Cleland JG,Dickstein K,Metra M,Ng LL,Samani NJ,van Veldhuisen DJ,Zannad F,Voors AA,Lang CC

更新日期：2020-03-25 00:00:00

abstract：OBJECTIVES:Regional presynaptic sympathetic innervation varies considerably in the cardiomyopathic human heart, as shown in previous studies in vivo and in vitro. The goal of the present study was to correlate markers of presynaptic sympathetic innervation with local measurement of the postsynaptic beta-adrenergic syst...

journal_title：European journal of heart failure

authors： Ungerer M,Weig HJ,Kübert S,Overbeck M,Bengel F,Schömig A,Schwaiger M

更新日期：2000-03-01 00:00:00

abstract：AIMS:Myostatin inhibits myoblast differentiation/proliferation and may play a role in heart failure (HF) and reverse remodelling after left ventricular assist device (LVAD) support. This study sought to characterize myostatin expression and activation in advanced HF before and after LVAD support. METHODS AND RESULTS:L...

journal_title：European journal of heart failure

authors： George I,Bish LT,Kamalakkannan G,Petrilli CM,Oz MC,Naka Y,Sweeney HL,Maybaum S

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Information about the occurrence of heart failure in the acute phase of myocardial infarction (MI) in diabetic patients and its impact on prognosis are sparse. AIM:The purpose of the present study was to describe how MI patients with diabetes mellitus (DM) differed from MI patients without DM with respect t...

journal_title：European journal of heart failure

authors： Melchior T,Rask-Madsen C,Torp-Pedersen C,Hildebrandt P,Køber L,Jensen G

更新日期：2001-01-01 00:00:00

abstract：AIMS:To investigate the relationship between central venous pressure (CVP) at presentation to the emergency room (ER) and the risk of cardiac rehospitalization and mortality in patients with decompensated heart failure (DHF). METHODS AND RESULTS:Central venous pressure was determined non-invasively using high-resoluti...

journal_title：European journal of heart failure

authors： Uthoff H,Thalhammer C,Potocki M,Reichlin T,Noveanu M,Aschwanden M,Staub D,Arenja N,Socrates T,Twerenbold R,Mutschmann-Sanchez S,Heinisch C,Jaeger KA,Mebazaa A,Mueller C

更新日期：2010-05-01 00:00:00

abstract：:The vast majority of acute heart failure episodes are characterized by increasing symptoms and signs of congestion with volume overload. The goal of therapy in those patients is the relief of congestion through achieving a state of euvolaemia, mainly through the use of diuretic therapy. The appropriate use of diuretic...

journal_title：European journal of heart failure

authors： Mullens W,Damman K,Harjola VP,Mebazaa A,Brunner-La Rocca HP,Martens P,Testani JM,Tang WHW,Orso F,Rossignol P,Metra M,Filippatos G,Seferovic PM,Ruschitzka F,Coats AJ

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:No specific guidelines exist on how to manage renal dysfunction (RD) in patients with chronic heart failure (CHF). AIMS:To identify the proportion of patients with moderate to severe RD and CHF who showed an improvement in their renal function in response to a systematic management algorithm. METHODS:Stabl...

journal_title：European journal of heart failure

authors： de Silva R,Nikitin NP,Witte KK,Rigby AS,Loh H,Nicholson A,Bhandari S,Clark AL,Cleland JG

更新日期：2007-04-01 00:00:00

abstract：AIMS:Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) is a strong biochemical marker of heart failure and left ventricular dysfunction (LVD). Due to renal arterio-venous clearance of NT-proBNP and the correlation of plasma concentrations with renal function, we hypothesized that NT-proBNP may have potential ...

journal_title：European journal of heart failure

authors： Jungbauer CG,Buchner S,Birner C,Resch M,Heinicke N,Debl K,Buesing M,Biermeier D,Schmitz G,Riegger G,Luchner A

更新日期：2010-04-01 00:00:00

abstract：AIMS:Remote patient management (telemonitoring) may help to detect early signs of cardiac decompensation, allowing optimization of and adherence to treatments in chronic heart failure (CHF). Two meta-analyses have suggested that telemedicine in CHF can reduce mortality by 30-35%. The aim of the TIM-HF study was to inve...

journal_title：European journal of heart failure

authors： Koehler F,Winkler S,Schieber M,Sechtem U,Stangl K,Böhm M,Boll H,Kim SS,Koehler K,Lücke S,Honold M,Heinze P,Schweizer T,Braecklein M,Kirwan BA,Gelbrich G,Anker SD,TIM-HF Investigators.

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Cardiac angiotensin converting enzyme (ACE) is activated by an increase in wall stress and is involved in remodeling processes. Heart failure is often treated with ACE inhibitors and diuretics although diuretic treatment could activate the renin-angiotensin system (RAS). AIMS:To examine the effects of diure...

journal_title：European journal of heart failure

authors： Seeland U,Kouchi I,Zolk O,Jockenhövel F,Itter G,Linz W,Böhm M

更新日期：2003-06-01 00:00:00

abstract：AIMS:Calcium channel plays an important role in the autoimmune pathogenesis of idiopathic dilated cardiomyopathy (DCM). Autoantibodies have emerged as a new upstream target of sudden death in DCM. We sought to validate the hypothesis that autoantibodies against l-type calcium channel (CC-AAbs) are arrhythmogenic and le...

journal_title：European journal of heart failure

authors： Xiao H,Wang M,Du Y,Yuan J,Cheng X,Chen Z,Zou A,Wei F,Zhao G,Liao YH

更新日期：2011-03-01 00:00:00

abstract：:Dilated cardiomyopathy (DCM) represents a particular aetiology of systolic heart failure that frequently has a genetic background and usually affects young patients with few co-morbidities. The prognosis of DCM has improved substantially during the last decades due to more accurate aetiological characterization, the r...

journal_title：European journal of heart failure

authors： Merlo M,Cannatà A,Gobbo M,Stolfo D,Elliott PM,Sinagra G

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Limited comparative studies assessing the health-related quality of life (HRQL) in heart failure (HF) patients with preserved vs. low ejection fraction (LVEF) have been disparate. AIMS:The aims of this study were a) to characterize HRQL in a large population of HF patients with preserved and low LVEF and b)...

journal_title：European journal of heart failure

authors： Lewis EF,Lamas GA,O'Meara E,Granger CB,Dunlap ME,McKelvie RS,Probstfield JL,Young JB,Michelson EL,Halling K,Carlsson J,Olofsson B,McMurray JJ,Yusuf S,Swedberg K,Pfeffer MA,CHARM Investigators.

更新日期：2007-01-01 00:00:00

abstract：AIMS:Non-invasive measures of cardiac mechanical function may have the potential to serve as markers of risk for heart failure; however, limited data exist regarding clinical correlates and heritability of these measures in the community. METHODS AND RESULTS:We used speckle-tracking echocardiography to assess LV strai...

journal_title：European journal of heart failure

authors： Cheng S,McCabe EL,Larson MG,Chen MH,Osypiuk E,Lehman BT,Stantchev P,Aragam J,Solomon SD,Benjamin EJ,Vasan RS

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:EMPEROR-Preserved is an ongoing trial evaluating the effect of empagliflozin in patients with heart failure with preserved ejection fraction (HFpEF). This report describes the baseline characteristics of the EMPEROR-Preserved cohort and compares it with patients enrolled in prior HFpEF trials. METHODS:EMPER...

journal_title：European journal of heart failure

authors： Anker SD,Butler J,Filippatos G,Khan MS,Ferreira JP,Bocchi E,Böhm M,Rocca HPB,Choi DJ,Chopra V,Chuquiure E,Giannetti N,Gomez-Mesa JE,Janssens S,Januzzi JL,Gonzalez-Juanatey JR,Merkely B,Nicholls SJ,Perrone SV,Piña IL

更新日期：2020-11-29 00:00:00

abstract：BACKGROUND:The EURObservational Research Programme is a rolling programme of cardiovascular registries and surveys of the European Society of Cardiology (ESC). These registries will provide information on the nature of cardiovascular disease and its management. This manuscript provides an update on new literature on pe...

journal_title：European journal of heart failure

authors： Sliwa K,Hilfiker-Kleiner D,Mebazaa A,Petrie MC,Maggioni AP,Regitz-Zagrosek V,Schaufelberger M,Tavazzi L,van Veldhuisen DJ,Roos-Hesslink JW,Shah AJ,Seferovic PM,Elkayam U,van Spaendonck-Zwarts K,Bachelier-Walenta K,Mouquet F

更新日期：2014-05-01 00:00:00

abstract：AIMS:A restrictive transmitral filling (RF) pattern predicts increased mortality in heart failure (HF) with reduced left ventricular (LV) systolic function. We performed a combined evaluation of LV function and RF for prognosis in patients with HF with and without systolic dysfunction. METHODS AND RESULTS:Doppler echo...

journal_title：European journal of heart failure

authors： Akkan D,Kjaergaard J,Møller JE,Hassager C,Torp-Pedersen C,Køber L,EchoCardiography and Heart Outcome Study (ECHOS) investigators.

更新日期：2008-07-01 00:00:00

abstract：UNLABELLED:IMS: Recurrent myocardial infarction (MI) is common after a first MI and is associated with increased morbidity and mortality. Predictors and prognosis of a recurrent MI with contemporary management are not well known. METHODS AND RESULTS:We assessed the predictors and prognostic impact of a first recurrent...

journal_title：European journal of heart failure

authors： Thune JJ,Signorovitch JE,Kober L,McMurray JJ,Swedberg K,Rouleau J,Maggioni A,Velazquez E,Califf R,Pfeffer MA,Solomon SD

更新日期：2011-02-01 00:00:00

abstract：AIMS:To assess adherence to medical treatment in patients with heart failure (HF) using a specific questionnaire and measurement of the serum concentration of digoxin. METHODS AND RESULTS:Forty patients with symptomatic HF and a clinical indication for digoxin were included in this pilot study. The assessment of adher...

journal_title：European journal of heart failure

authors： Muzzarelli S,Brunner-La Rocca H,Pfister O,Foglia P,Moschovitis G,Mombelli G,Stricker H

更新日期：2010-04-01 00:00:00

abstract：AIMS:Heart failure (HF) quality registries report quality of care but it is unknown whether they improve outcomes. The aims were to assess predictors of enrolment in a HF registry, test the hypothesis that enrolment in a HF registry is associated with reduced mortality, and assess potential explanatory factors for this...

journal_title：European journal of heart failure

authors： Lund LH,Carrero JJ,Farahmand B,Henriksson KM,Jonsson Å,Jernberg T,Dahlström U

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVES:To compare the efficacy of the homeopathic Crataegus preparation Cralonin for non-inferiority to standard treatment for mild cardiac insufficiency. METHODS:Multicentre non-randomised cohort study in patients aged 50-75 years in New York Heart Association class II. Patients received Cralonin (n=110) or ACE i...

journal_title：European journal of heart failure

authors： Schröder D,Weiser M,Klein P

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND:Approximately one third of patients with chronic heart failure have left bundle branch block (LBBB) on their 12-lead ECG. METHODS AND RESULTS:1418 consecutive patients (average (SD) age 70.5 (10.4) years; 74% male) first seen in a community heart failure clinic between December 2001 and June 2006 had a 12 l...

journal_title：European journal of heart failure

authors： Clark AL,Goode K,Cleland JG

更新日期：2008-07-01 00:00:00

abstract：AIMS:Exercise-derived parameters, specifically peak exercise oxygen uptake (peak VO2 ) and minute ventilation/carbon dioxide relationship slope (VE/VCO2 slope), have a pivotal prognostic value in heart failure (HF). It is unknown how the prognostic threshold of peak VO2 and VE/VCO2 slope has changed over the last 20 ye...

journal_title：European journal of heart failure

authors： Paolillo S,Veglia F,Salvioni E,Corrà U,Piepoli M,Lagioia R,Limongelli G,Sinagra G,Cattadori G,Scardovi AB,Metra M,Senni M,Bonomi A,Scrutinio D,Raimondo R,Emdin M,Magrì D,Parati G,Re F,Cicoira M,Minà C,Correale M

更新日期：2019-02-01 00:00:00