Heart failure with normal ejection fraction is uncommon in acute myocardial infarction settings but associated with poor outcomes: a study of 91,360 patients admitted with index myocardial infarction between 1998 and 2010.


AIM:Data are scant on the incidence and prognosis of heart failure (HF) with normal ejection fraction (HFNEF, EF >49%) in an acute myocardial infarction (AMI) setting. The aim of this study was to examine incidence and predictors of HFNEF during an index acute myocardial infarction (AMI) and its subsequent associations with patient outcomes. METHODS AND RESULTS:This study analysed 91 360 patients with LVEF data from the SWEDEHEART registry on consecutive AMI patients between 1998 and 2010. Echocardiography or LV angiography was used to assess LVEF. In-hospital HF diagnoses required presence of crackles, and use of i.v. diuretics or inotropic drugs during admission. Among HF patients, the proportion of HFNEF patients increased (from 18% to 31%) during the period. Incidence of HFNEF in the AMI population remained fairly unchanged (from 7.7% to 8.1%). In contrast, the proportion of HF patients with reduced EF (HFREF, EF ≤49%) declined (from 47% to 26%), as did the proportion of REF patients without HF (from 20% to 16%). AMI patients with NEF without HF increased (from 25% to 50%). HFREF and HFNEF patients showed considerably higher long-term mortality compared with patients with no HF, irrespective of EF [the HFREF and HFNEF hazard ratio, compared with NEF, was 4.5 (4.4-4-6) and 3.3 (3.1-3.4), respectively, and 1.6 (1.5-1.65) for REF]. The adjusted HFNEF hazard ratio, compared with NEF, was 1.9 (1.8-2.0). Age, female gender, diabetes mellitus, hypertension, AF, and chronic kidney disease were strong predictors of HFNEF (P < 0.001). CONCLUSION:The proportion of AMI patients with HFNEF is constant over time. HFNEF patients have a considerably worse long-term prognosis compared with patients without clinical HF, irrespective of EF.


Eur J Heart Fail


Desta L,Jernberg T,Spaak J,Hofman-Bang C,Persson H




Has Abstract


2016-01-01 00:00:00












  • Baseline Characteristics of Patients with Heart Failure with Preserved Ejection Fraction in the EMPEROR-Preserved Trial.

    abstract:BACKGROUND:EMPEROR-Preserved is an ongoing trial evaluating the effect of empagliflozin in patients with heart failure with preserved ejection fraction (HFpEF). This report describes the baseline characteristics of the EMPEROR-Preserved cohort and compares it with patients enrolled in prior HFpEF trials. METHODS:EMPER...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Anker SD,Butler J,Filippatos G,Khan MS,Ferreira JP,Bocchi E,Böhm M,Rocca HPB,Choi DJ,Chopra V,Chuquiure E,Giannetti N,Gomez-Mesa JE,Janssens S,Januzzi JL,Gonzalez-Juanatey JR,Merkely B,Nicholls SJ,Perrone SV,Piña IL

    更新日期:2020-11-29 00:00:00

  • Early right ventricular response to cardiac resynchronization therapy: impact on clinical outcomes.

    abstract:AIMS:Right ventricular (RV) dysfunction has been associated with a worse outcome in heart failure patients undergoing CRT. However, evidence on the RV response to CRT is controversial and there are no data regarding the early effects of CRT on RV function (RVF). We sought to investigate whether a CRT device favourably ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Stolfo D,Tonet E,Merlo M,Barbati G,Gigli M,Pinamonti B,Ramani F,Zecchin M,Sinagra G

    更新日期:2016-02-01 00:00:00

  • Myocarditis as a precipitating factor for heart failure: evaluation and 1-year follow-up using cardiovascular magnetic resonance and endomyocardial biopsy.

    abstract:AIMS:The aim of this study was to evaluate myocarditis as a precipitating factor for heart failure using cardiovascular magnetic resonance (CMR) and endomyocardial biopsy. METHODS AND RESULTS:Eighty-five patients with suspected myocarditis and 20 controls were evaluated. Seventy-one patients with positive CMR were ref...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Mavrogeni S,Spargias C,Bratis C,Kolovou G,Markussis V,Papadopoulou E,Constadoulakis P,Papadimitropoulos M,Douskou M,Pavlides G,Cokkinos D

    更新日期:2011-08-01 00:00:00

  • Attenuation of postoperative noradrenaline need by nitric oxide inhibition using L-NMMA.

    abstract::In the present report we describe that NG-monomethyl-L-arginine acetate, a non-specific nitric oxide synthesis inhibitor, administered at 1 mg kg(-1) h(-1) to a patient with critical hypotension following mitral valve surgery combined with passive containment surgery, increased the urinary output and arterial blood pr...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Franco-Cereceda A,Holm P,Bredin F,Adding C

    更新日期:2005-12-01 00:00:00

  • Association between enrolment in a heart failure quality registry and subsequent mortality-a nationwide cohort study.

    abstract:AIMS:Heart failure (HF) quality registries report quality of care but it is unknown whether they improve outcomes. The aims were to assess predictors of enrolment in a HF registry, test the hypothesis that enrolment in a HF registry is associated with reduced mortality, and assess potential explanatory factors for this...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Lund LH,Carrero JJ,Farahmand B,Henriksson KM,Jonsson Å,Jernberg T,Dahlström U

    更新日期:2017-09-01 00:00:00

  • Family caregiving and congestive heart failure. Review and analysis.

    abstract:BACKGROUND:There is increasing evidence that discharge planning and post-discharge support for CHF patients can contribute greatly to the medical management of heart failure (CHF) in the community and that the quality of the CHF patient's close personal relationships can influence outcome in CHF. However, there has bee...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审


    authors: Molloy GJ,Johnston DW,Witham MD

    更新日期:2005-06-01 00:00:00

  • The dynamic assessment of right-ventricular function and its relation to exercise capacity in heart failure.

    abstract:AIMS:To evaluate right-ventricular (RV) function during stress echocardiography (SE) and to assess its relationship with exercise capacity in heart failure (HF) patients. METHODS AND RESULTS:We included 88 patients aged 60.9 +/- 11.2 years with a mean LVEF of 27.2 +/- 9.5%. The following RV parameters were measured at...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Rubis P,Podolec P,Kopec G,Olszowska M,Tracz W

    更新日期:2010-03-01 00:00:00

  • Experience of commencing Carvedilol in elderly patients with heart failure in a routine outpatient clinic.

    abstract::Carvedilol has been shown to be beneficial for patients with heart failure, but it is not clear how it should be initiated in routine clinical practice, particularly in the elderly. This study is a retrospective review of 19 patients of age 80+/-4 years with heart failure, who had Carvedilol treatment initiated in a r...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Owen A

    更新日期:2000-09-01 00:00:00

  • The prognostic significance of heart failure with preserved left ventricular ejection fraction: a literature-based meta-analysis.

    abstract:AIMS:Heart failure (HF) with normal or preserved left ventricular (LV) ejection fraction (HFPEF) has been reported to be associated with similar outcome as HF with reduced EF (HFREF) in registry-based and epidemiological analyses, but many of these studies excluded patients who did not have EF measurements. Conversely,...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,meta分析


    authors: Somaratne JB,Berry C,McMurray JJ,Poppe KK,Doughty RN,Whalley GA

    更新日期:2009-09-01 00:00:00

  • Utility of lung ultrasound in predicting pulmonary and cardiac pressures.

    abstract:AIMS:Quantification of linear lung ultrasound (LUS) artefacts (B-lines) represents a novel, non-invasive approach to assess pulmonary congestion. We investigated the relationship between the number of B-lines (vertical artefacts arising from the pleural line) and intracardiac pressures. METHODS AND RESULTS:Prior to sc...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Platz E,Lattanzi A,Agbo C,Takeuchi M,Resnic FS,Solomon SD,Desai AS

    更新日期:2012-11-01 00:00:00

  • Hereditary hemochromatosis gene (HFE) mutations C282Y, H63D and S65C in patients with idiopathic dilated cardiomyopathy.

    abstract:BACKGROUND:Hereditary hemochromatosis (HH), a common autosomal recessive disease, leads to excessive iron accumulation in some organs, including the heart. It is therefore not surprising that cardiomyopathy is one of the most severe complications of HH. The HFE gene defects have been thought to contribute to idiopathic...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Hannuksela J,Leppilampi M,Peuhkurinen K,Kärkkäinen S,Saastamoinen E,Heliö T,Kaartinen M,Nieminen MS,Nieminen P,Parkkila S

    更新日期:2005-01-01 00:00:00

  • Heart failure with preserved ejection fraction induces molecular, mitochondrial, histological, and functional alterations in rat respiratory and limb skeletal muscle.

    abstract:AIMS:Peripheral muscle dysfunction is a key mechanism contributing to exercise intolerance (i.e. breathlessness and fatigue) in heart failure patients with preserved ejection fraction (HFpEF); however, the underlying molecular and cellular mechanisms remain unknown. We therefore used an animal model to elucidate potent...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Bowen TS,Rolim NP,Fischer T,Baekkerud FH,Medeiros A,Werner S,Brønstad E,Rognmo O,Mangner N,Linke A,Schuler G,Silva GJ,Wisløff U,Adams V,Optimex Study Group.

    更新日期:2015-03-01 00:00:00

  • Plasma B-type natriuretic peptide and anti-inflammatory cytokine interleukin-10 levels predict adverse clinical outcome in chronic heart failure patients with depressive symptoms: a 1-year follow-up study.

    abstract:AIMS:To assess the prognostic value of a wide spectrum of neurohormonal and inflammatory markers along with functional status and exercise capacity, in hospitalized chronic heart failure (CHF) patients with depressive symptoms. METHODS AND RESULTS:A total of 300 consecutive hospitalized CHF patients were screened for ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Parissis JT,Farmakis D,Nikolaou M,Birmpa D,Bistola V,Paraskevaidis I,Ikonomidis I,Gaitani S,Venetsanou K,Filippatos G,Kremastinos DT

    更新日期:2009-10-01 00:00:00

  • Long-term outcome in patients with Takotsubo syndrome presenting with severely reduced left ventricular ejection fraction.

    abstract:AIM:To evaluate the long-term outcome of patients with Takotsubo syndrome (TTS) and severely reduced left ventricular ejection fraction (LVEF ≤ 35%) at presentation. METHODS AND RESULTS:The study population included 326 patients (mean age 69.5 ± 10.7 years, 28 male) with TTS enrolled in the Takotsubo Italian Network, ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Citro R,Radano I,Parodi G,Di Vece D,Zito C,Novo G,Provenza G,Bellino M,Prota C,Silverio A,Antonini-Canterin F,Rigo F,Vriz O,Galasso G,Bossone E,Salerno-Uriarte J,Piscione F

    更新日期:2019-06-01 00:00:00

  • Heart failure prognosis over time: how the prognostic role of oxygen consumption and ventilatory efficiency during exercise has changed in the last 20 years.

    abstract:AIMS:Exercise-derived parameters, specifically peak exercise oxygen uptake (peak VO2 ) and minute ventilation/carbon dioxide relationship slope (VE/VCO2 slope), have a pivotal prognostic value in heart failure (HF). It is unknown how the prognostic threshold of peak VO2 and VE/VCO2 slope has changed over the last 20 ye...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究


    authors: Paolillo S,Veglia F,Salvioni E,Corrà U,Piepoli M,Lagioia R,Limongelli G,Sinagra G,Cattadori G,Scardovi AB,Metra M,Senni M,Bonomi A,Scrutinio D,Raimondo R,Emdin M,Magrì D,Parati G,Re F,Cicoira M,Minà C,Correale M

    更新日期:2019-02-01 00:00:00

  • Peritoneal dialysis relieves clinical symptoms and is well tolerated in patients with refractory heart failure and chronic kidney disease.

    abstract:AIMS:The aim of the study was to evaluate the efficacy and clinical outcome of peritoneal dialysis (PD) treatment in patients with severe refractory heart failure (HF) and chronic kidney disease (CKD). METHODS AND RESULTS:The PD treatment was performed in 118 patients [49.2% New York Heart Association (NYHA) III and 5...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Koch M,Haastert B,Kohnle M,Rump LC,Kelm M,Trapp R,Aker S

    更新日期:2012-05-01 00:00:00

  • A randomized trial of the addition of home-based exercise to specialist heart failure nurse care: the Birmingham Rehabilitation Uptake Maximisation study for patients with Congestive Heart Failure (BRUM-CHF) study.

    abstract:AIMS:Supervised exercise can benefit selected patients with heart failure, however the effectiveness of home-based exercise remains uncertain. We aimed to assess the effectiveness of a home-based exercise programme in addition to specialist heart failure nurse care. METHODS AND RESULTS:This was a randomized controlled...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验


    authors: Jolly K,Taylor RS,Lip GY,Davies M,Davis R,Mant J,Singh S,Greenfield S,Ingram J,Stubley J,Bryan S,Stevens A

    更新日期:2009-02-01 00:00:00

  • Right ventricular dysfunction in heart failure with preserved ejection fraction: a systematic review and meta-analysis.

    abstract:AIMS:Right ventricular (RV) dysfunction and pulmonary hypertension (PH) are increasingly recognized in heart failure with preserved ejection fraction (HFpEF). The prevalence and prognostic value of RV dysfunction in HFpEF have been widely but variably reported. We therefore conducted a systematic review and meta-analys...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,meta分析,评审


    authors: Gorter TM,Hoendermis ES,van Veldhuisen DJ,Voors AA,Lam CS,Geelhoed B,Willems TP,van Melle JP

    更新日期:2016-12-01 00:00:00

  • Gut dysbiosis and heart failure: navigating the universe within.

    abstract::Alternations in gut microbial composition (i.e. loss of microbial diversity or 'gut dysbiosis') have been associated with heart failure with reduced ejection fraction (HFrEF). It has also been suggested that increased chronic low-level inflammation and immune system dysregulation seen in patients with HFrEF could be r...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审


    authors: Madan S,Mehra MR

    更新日期:2020-04-01 00:00:00

  • MicroRNA signatures differentiate preserved from reduced ejection fraction heart failure.

    abstract:AIMS:Differentiation of heart failure with reduced (HFrEF) or preserved (HFpEF) ejection fraction independent of echocardiography is challenging in the community. Diagnostic strategies based on monitoring circulating microRNA (miRNA) levels may prove to be of clinical value in the near future. The aim of this study was...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Watson CJ,Gupta SK,O'Connell E,Thum S,Glezeva N,Fendrich J,Gallagher J,Ledwidge M,Grote-Levi L,McDonald K,Thum T

    更新日期:2015-04-01 00:00:00

  • The role of correction of anaemia in patients with congestive heart failure: a short review.

    abstract::Many patients with Congestive Heart Failure (CHF) are anaemic. This anaemia is associated with more severe CHF and a higher incidence of mortality, hospitalisation and morbidity. The only way to prove that the anaemia is causing this worsening of CHF is to correct it. We review here some of the published papers about ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审


    authors: Silverberg DS,Wexler D,Iaina A,Schwartz D

    更新日期:2008-09-01 00:00:00

  • Prognostic value of cardiopulmonary exercise testing in cardiac amyloidosis.

    abstract:AIMS:In amyloid patients, cardiac involvement dramatically worsens functional capacity and prognosis. We sought to study how the cardiopulmonary exercise test (CPET) could help in functional assessment and risk stratification of patients with cardiac amyloidosis (CA). METHODS AND RESULTS:We carried out a multicentre s...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Nicol M,Deney A,Lairez O,Vergaro G,Emdin M,Carecci A,Inamo J,Montfort A,Neviere R,Damy T,Harel S,Royer B,Baudet M,Cohen-Solal A,Arnulf B,Logeart D

    更新日期:2020-10-02 00:00:00

  • Evaluation of left ventricular function and mitral regurgitation during left ventricular-based pacing in patients with heart failure.

    abstract:BACKGROUND:Beneficial effects of left ventricular (LV)-based pacing on acute hemodynamic parameters were reported in several series, but only a few studies examined the long-term effects of this new pacing procedure. AIMS:To assess long-term effects of permanent LV-based pacing on LV function and mitral regurgitation ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Etienne Y,Mansourati J,Touiza A,Gilard M,Bertault-Valls V,Guillo P,Boschat J,Blanc JJ

    更新日期:2001-08-01 00:00:00

  • Long-term effectiveness of the combined minute ventilation and patient activity sensors as predictor of heart failure events in patients treated with cardiac resynchronization therapy: Results of the Clinical Evaluation of the Physiological Diagnosis Func

    abstract:AIMS:Monitoring early signs of clinical deterioration could allow physicians to adjust medical treatment for patients at risk of acute heart failure decompensation. To date, several strategies using different surrogate measures of clinical status emerged, but none has yet been proven to predict clinical events. We hypo...

    journal_title:European journal of heart failure

    pub_type: 临床试验,杂志文章


    authors: Auricchio A,Gold MR,Brugada J,Nölker G,Arunasalam S,Leclercq C,Defaye P,Calò L,Baumann O,Leyva F

    更新日期:2014-06-01 00:00:00

  • Regional pre- and postsynaptic sympathetic system in the failing human heart--regulation of beta ARK-1.

    abstract:OBJECTIVES:Regional presynaptic sympathetic innervation varies considerably in the cardiomyopathic human heart, as shown in previous studies in vivo and in vitro. The goal of the present study was to correlate markers of presynaptic sympathetic innervation with local measurement of the postsynaptic beta-adrenergic syst...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Ungerer M,Weig HJ,Kübert S,Overbeck M,Bengel F,Schömig A,Schwaiger M

    更新日期:2000-03-01 00:00:00

  • Predicting hospitalization due to worsening heart failure using daily weight measurement: analysis of the Trans-European Network-Home-Care Management System (TEN-HMS) study.

    abstract:AIMS:We sought to test the utility of weight gain algorithms to predict episodes of worsening heart failure (WHF) using home-telemonitoring data collected as part of the TEN-HMS study. METHODS AND RESULTS:Simple rule-of-thumb (RoT) algorithms (i.e. 3 lbs in 1 day and 5 lbs in 3 days) and a moving average convergence d...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Zhang J,Goode KM,Cuddihy PE,Cleland JG,TEN-HMS Investigators.

    更新日期:2009-04-01 00:00:00

  • Selenium- and zinc-deficient cardiomyopathy in human intestinal malabsorption: preliminary results of selenium/zinc infusion.

    abstract:AIMS:Patients with intestinal malabsorption may develop cardiac dysfunction the origin of which is often unclear. We sought to investigate the pathogenesis of dilated cardiomyopathy in human malabsorption. METHODS AND RESULTS:Eighteen patients with intestinal bypass as treatment for severe obesity and cardiomyopathy u...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Frustaci A,Sabbioni E,Fortaner S,Farina M,del Torchio R,Tafani M,Morgante E,Ciriolo MR,Russo MA,Chimenti C

    更新日期:2012-02-01 00:00:00

  • The efficacy and safety of Crataegus extract WS 1442 in patients with heart failure: the SPICE trial.

    abstract:BACKGROUND:Crataegus preparations have been used for centuries especially in Europe. To date, no proper data on their efficacy and safety as an add-on-treatment are available. Therefore a large morbidity/mortality trial was performed. AIM:To investigate the efficacy and safety of an add-on treatment with Crataegus ext...

    journal_title:European journal of heart failure

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Holubarsch CJ,Colucci WS,Meinertz T,Gaus W,Tendera M,Survival and Prognosis: Investigation of Crataegus Extract WS 1442 in CHF (SPICE) trial study group.

    更新日期:2008-12-01 00:00:00

  • Outcomes in patients hospitalized for heart failure and chronic obstructive pulmonary disease: differences in clinical profile and treatment between 2002 and 2009.

    abstract:AIMS:Heart failure (HF) and chronic obstructive pulmonary disease (COPD) frequently co-exist, and each is a major public health issue. In a large cohort of hospitalized HF patients, we evaluated: (i) the impact of COPD on clinical outcomes; (ii) whether outcomes and treatments changed from 2002 to 2009; and (iii) the r...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Staszewsky L,Cortesi L,Tettamanti M,Dal Bo GA,Fortino I,Bortolotti A,Merlino L,Latini R,Roncaglioni MC,Baviera M

    更新日期:2016-07-01 00:00:00

  • Heart failure in a multiethnic population in Kuala Lumpur, Malaysia.

    abstract:BACKGROUND:There are established differences in cardiovascular disease in different racial groups. Worldwide, the literature regarding the clinical epidemiology of congestive heart failure (CHF) in non-white populations is scarce. OBJECTIVES:To document the prevalence of CHF in the multiracial population of Malaysia, ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章


    authors: Chong AY,Rajaratnam R,Hussein NR,Lip GY

    更新日期:2003-08-01 00:00:00