Abstract:
AIM:Data are scant on the incidence and prognosis of heart failure (HF) with normal ejection fraction (HFNEF, EF >49%) in an acute myocardial infarction (AMI) setting. The aim of this study was to examine incidence and predictors of HFNEF during an index acute myocardial infarction (AMI) and its subsequent associations with patient outcomes. METHODS AND RESULTS:This study analysed 91 360 patients with LVEF data from the SWEDEHEART registry on consecutive AMI patients between 1998 and 2010. Echocardiography or LV angiography was used to assess LVEF. In-hospital HF diagnoses required presence of crackles, and use of i.v. diuretics or inotropic drugs during admission. Among HF patients, the proportion of HFNEF patients increased (from 18% to 31%) during the period. Incidence of HFNEF in the AMI population remained fairly unchanged (from 7.7% to 8.1%). In contrast, the proportion of HF patients with reduced EF (HFREF, EF ≤49%) declined (from 47% to 26%), as did the proportion of REF patients without HF (from 20% to 16%). AMI patients with NEF without HF increased (from 25% to 50%). HFREF and HFNEF patients showed considerably higher long-term mortality compared with patients with no HF, irrespective of EF [the HFREF and HFNEF hazard ratio, compared with NEF, was 4.5 (4.4-4-6) and 3.3 (3.1-3.4), respectively, and 1.6 (1.5-1.65) for REF]. The adjusted HFNEF hazard ratio, compared with NEF, was 1.9 (1.8-2.0). Age, female gender, diabetes mellitus, hypertension, AF, and chronic kidney disease were strong predictors of HFNEF (P < 0.001). CONCLUSION:The proportion of AMI patients with HFNEF is constant over time. HFNEF patients have a considerably worse long-term prognosis compared with patients without clinical HF, irrespective of EF.
journal_name
Eur J Heart Failjournal_title
European journal of heart failureauthors
Desta L,Jernberg T,Spaak J,Hofman-Bang C,Persson Hdoi
10.1002/ejhf.416subject
Has Abstractpub_date
2016-01-01 00:00:00pages
46-53issue
1eissn
1388-9842issn
1879-0844journal_volume
18pub_type
杂志文章abstract:AIMS:We investigated the association between quantified metabolite, lipid and lipoprotein measures and incident heart failure hospitalisation (HFH) in the elderly, and examined whether circulating metabolic measures improve HFH prediction. METHODS AND RESULTS:Overall, 80 metabolic measures from the PROspective Study o...
journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究,随机对照试验
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abstract:AIMS:Undetected atrial fibrillation (AF) may be common in the heart failure with preserved ejection fraction (HFpEF) population, and failure to detect this may lead to the missing of opportunities to prevent associated subclinical cerebral infarctions (SCIs) and cognitive decline. METHODS AND RESULTS:We studied 1527 p...
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journal_title:European journal of heart failure
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更新日期:2019-12-01 00:00:00
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journal_title:European journal of heart failure
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2006.03.002
更新日期:2006-12-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,评审
doi:10.1016/s1388-9842(02)00118-6
更新日期:2003-01-01 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:European journal of heart failure
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/s1388-9842(98)00005-1
更新日期:1999-03-01 00:00:00
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journal_title:European journal of heart failure
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journal_title:European journal of heart failure
pub_type: 杂志文章
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更新日期:2020-11-02 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ejheart.2007.04.006
更新日期:2007-08-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.132
更新日期:2014-08-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1093/eurjhf/hfr127
更新日期:2011-12-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/s1388-9842(02)00116-2
更新日期:2002-12-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
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更新日期:2014-12-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2004.04.008
更新日期:2005-01-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
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更新日期:2011-05-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/s1388-9842(01)00145-3
更新日期:2001-08-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2008.06.013
更新日期:2008-08-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章,meta分析
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更新日期:2009-09-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
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更新日期:2013-10-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2004.03.003
更新日期:2004-12-01 00:00:00
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journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2004.03.007
更新日期:2005-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/eurjhf/hft003
更新日期:2013-05-01 00:00:00