Heart failure with normal ejection fraction is uncommon in acute myocardial infarction settings but associated with poor outcomes: a study of 91,360 patients admitted with index myocardial infarction between 1998 and 2010.

Abstract:

AIM:Data are scant on the incidence and prognosis of heart failure (HF) with normal ejection fraction (HFNEF, EF >49%) in an acute myocardial infarction (AMI) setting. The aim of this study was to examine incidence and predictors of HFNEF during an index acute myocardial infarction (AMI) and its subsequent associations with patient outcomes. METHODS AND RESULTS:This study analysed 91 360 patients with LVEF data from the SWEDEHEART registry on consecutive AMI patients between 1998 and 2010. Echocardiography or LV angiography was used to assess LVEF. In-hospital HF diagnoses required presence of crackles, and use of i.v. diuretics or inotropic drugs during admission. Among HF patients, the proportion of HFNEF patients increased (from 18% to 31%) during the period. Incidence of HFNEF in the AMI population remained fairly unchanged (from 7.7% to 8.1%). In contrast, the proportion of HF patients with reduced EF (HFREF, EF ≤49%) declined (from 47% to 26%), as did the proportion of REF patients without HF (from 20% to 16%). AMI patients with NEF without HF increased (from 25% to 50%). HFREF and HFNEF patients showed considerably higher long-term mortality compared with patients with no HF, irrespective of EF [the HFREF and HFNEF hazard ratio, compared with NEF, was 4.5 (4.4-4-6) and 3.3 (3.1-3.4), respectively, and 1.6 (1.5-1.65) for REF]. The adjusted HFNEF hazard ratio, compared with NEF, was 1.9 (1.8-2.0). Age, female gender, diabetes mellitus, hypertension, AF, and chronic kidney disease were strong predictors of HFNEF (P < 0.001). CONCLUSION:The proportion of AMI patients with HFNEF is constant over time. HFNEF patients have a considerably worse long-term prognosis compared with patients without clinical HF, irrespective of EF.

journal_name

Eur J Heart Fail

authors

Desta L,Jernberg T,Spaak J,Hofman-Bang C,Persson H

doi

10.1002/ejhf.416

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

46-53

issue

1

eissn

1388-9842

issn

1879-0844

journal_volume

18

pub_type

杂志文章
  • Association between enrolment in a heart failure quality registry and subsequent mortality-a nationwide cohort study.

    abstract:AIMS:Heart failure (HF) quality registries report quality of care but it is unknown whether they improve outcomes. The aims were to assess predictors of enrolment in a HF registry, test the hypothesis that enrolment in a HF registry is associated with reduced mortality, and assess potential explanatory factors for this...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.762

    authors: Lund LH,Carrero JJ,Farahmand B,Henriksson KM,Jonsson Å,Jernberg T,Dahlström U

    更新日期:2017-09-01 00:00:00

  • Decreasing trends in the incidence of heart failure after acute myocardial infarction from 1993-2004: a study of 175,216 patients with a first acute myocardial infarction in Sweden.

    abstract:AIMS:To investigate temporal trends in the risk of heart failure (HF) complicating acute myocardial infarction (AMI) and to determine whether these trends differ by gender or age. METHODS AND RESULTS:The national Swedish hospital discharge and death registries from 1993 to 2004 were used to calculate age- and gender-s...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfq205

    authors: Shafazand M,Rosengren A,Lappas G,Swedberg K,Schaufelberger M

    更新日期:2011-02-01 00:00:00

  • Preferences of heart failure patients in daily clinical practice: quality of life or longevity?

    abstract:AIMS:Knowledge of patient preferences is vital for delivering optimal healthcare. This study uses utility measurement to assess the preferences of heart failure (HF) patients regarding quality of life or longevity. The utility approach represents the perspective of a patient; facilitates the combination of mortality, m...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hft071

    authors: Kraai IH,Vermeulen KM,Luttik ML,Hoekstra T,Jaarsma T,Hillege HL

    更新日期:2013-10-01 00:00:00

  • Myocarditis as a precipitating factor for heart failure: evaluation and 1-year follow-up using cardiovascular magnetic resonance and endomyocardial biopsy.

    abstract:AIMS:The aim of this study was to evaluate myocarditis as a precipitating factor for heart failure using cardiovascular magnetic resonance (CMR) and endomyocardial biopsy. METHODS AND RESULTS:Eighty-five patients with suspected myocarditis and 20 controls were evaluated. Seventy-one patients with positive CMR were ref...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfr052

    authors: Mavrogeni S,Spargias C,Bratis C,Kolovou G,Markussis V,Papadopoulou E,Constadoulakis P,Papadimitropoulos M,Douskou M,Pavlides G,Cokkinos D

    更新日期:2011-08-01 00:00:00

  • Wall motion index, estimated glomerular filtration rate and mortality risk in patients with heart failure or myocardial infarction: a pooled analysis of 18,010 patients.

    abstract:AIMS:This study was designed to assess whether the prognostic significance of estimated glomerular filtration rate (eGFR) and left ventricular ejection fraction (LVEF) interact in populations with heart failure (HF) and myocardial infarction (MI). METHODS:Patients were recruited from four screening registers (N=18,010...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2008.04.006

    authors: Schou M,Torp-Pedersen C,Gustafsson F,Abdulla J,Kober L

    更新日期:2008-07-01 00:00:00

  • Aetiology-based clinical scenarios predict outcomes of transcatheter edge-to-edge tricuspid valve repair of functional tricuspid regurgitation.

    abstract:AIMS:Transcatheter tricuspid valve repair (TTVR) is an emerging technique to treat tricuspid regurgitation (TR). Predictors of adverse outcomes are scarce, and stratification by TR aetiologies is lacking. METHODS AND RESULTS:We report the bi-centre procedural outcomes of 164 patients undergoing TTVR for TR stratified ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.1547

    authors: Schlotter F,Orban M,Rommel KP,Besler C,von Roeder M,Braun D,Unterhuber M,Borger M,Hagl C,Orban M,Nabauer M,Massberg S,Thiele H,Hausleiter J,Lurz P

    更新日期:2019-09-01 00:00:00

  • D-Ribose improves diastolic function and quality of life in congestive heart failure patients: a prospective feasibility study.

    abstract::Patients with chronic coronary heart disease often suffer from congestive heart failure (CHF) despite multiple drug therapies. D-Ribose has been shown in animal models to improve cardiac energy metabolism and function following ischaemia. This was a prospective, double blind, randomized, crossover design study, to ass...

    journal_title:European journal of heart failure

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s1388-9842(03)00060-6

    authors: Omran H,Illien S,MacCarter D,St Cyr J,Lüderitz B

    更新日期:2003-10-01 00:00:00

  • High prevalence of subclinical cerebral infarction in patients with heart failure with preserved ejection fraction.

    abstract:AIMS:Undetected atrial fibrillation (AF) may be common in the heart failure with preserved ejection fraction (HFpEF) population, and failure to detect this may lead to the missing of opportunities to prevent associated subclinical cerebral infarctions (SCIs) and cognitive decline. METHODS AND RESULTS:We studied 1527 p...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.812

    authors: Cogswell RJ,Norby FL,Gottesman RF,Chen LY,Solomon S,Shah A,Alonso A

    更新日期:2017-10-01 00:00:00

  • Telomere length and outcomes in ischaemic heart failure: data from the COntrolled ROsuvastatin multiNAtional Trial in Heart Failure (CORONA).

    abstract:AIMS:Leucocyte telomere length is considered a marker of biological ageing and has been suggested to be shorter in patients with CAD and heart failure compared with healthy controls. The aim of this study was to determine whether telomere length is associated with clinical outcomes in patients with ischaemic heart fail...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/ejhf.237

    authors: Haver VG,Mateo Leach I,Kjekshus J,Fox JC,Wedel H,Wikstrand J,de Boer RA,van Gilst WH,McMurray JJ,van Veldhuisen DJ,van der Harst P

    更新日期:2015-03-01 00:00:00

  • Red cell distribution width and risk for first hospitalization due to heart failure: a population-based cohort study.

    abstract:AIMS:Red cell distribution width (RDW) has been associated with cardiovascular disease, but the relation to heart failure (HF) is unclear. We investigated the association between RDW and incidence of first hospitalization due to HF in a population-based cohort. METHODS AND RESULTS:Red cell distribution width was measu...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfr127

    authors: Borné Y,Smith JG,Melander O,Hedblad B,Engström G

    更新日期:2011-12-01 00:00:00

  • Emerging therapies in transthyretin amyloidosis - a new wave of hope after years of stagnancy?

    abstract::Transthyretin amyloidosis (ATTR) is a rare, yet underdiagnosed disease characterized by progressive impairment of neurologic and cardiac function due to deposition of misfolded transthyretin. Despite great efforts, such as the introduction of orthotopic liver transplant, the devastating prognosis for both variant and ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1002/ejhf.1695

    authors: Müller ML,Butler J,Heidecker B

    更新日期:2020-01-01 00:00:00

  • Serial measurement of galectin-3 in patients with chronic heart failure: results from the ProBNP Outpatient Tailored Chronic Heart Failure Therapy (PROTECT) study.

    abstract:AIMS:Galectin-3 is a prognostic heart failure (HF) biomarker that may mediate cardiac fibrosis. We examined the value of serial galectin-3 measurement for prognosis and response to therapy in chronic HF. METHODS AND RESULTS:A total of 151 subjects with LV systolic dysfunction (LVSD) were followed through 908 visits ov...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hft075

    authors: Motiwala SR,Szymonifka J,Belcher A,Weiner RB,Baggish AL,Sluss P,Gaggin HK,Bhardwaj A,Januzzi JL

    更新日期:2013-10-01 00:00:00

  • Usefulness of bifocal pacing in patients with heart failure and intraventricular conduction delay.

    abstract:BACKGROUND:Bifocal pacing (BFP) has been proposed as a feasible alternative to cardiac resynchronization therapy. AIM:To evaluate BFP in patients with severe heart failure and significant intraventricular conduction delay and to compare it with biventricular pacing (BVP). METHODS:Echocardiographic examination includi...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2006.09.003

    authors: Bulava A,Lukl J

    更新日期:2007-03-01 00:00:00

  • Heart failure with preserved ejection fraction: the impact of stricter definitions.

    abstract:AIMS:To determine the impact of internationally recognized criteria for the diagnosis of heart failure with preserved ejection fraction (HF-PEF) on the feasibility of recruitment into a HF-PEF trial. METHODS AND RESULTS:We reviewed the medical records of 5883 consecutive patients admitted with heart failure across eig...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.106

    authors: Patel HC,Hayward C,di Mario C,Cowie MR,Lyon AR,Rosen SD

    更新日期:2014-07-01 00:00:00

  • Heart failure and chronic obstructive pulmonary disease: diagnostic pitfalls and epidemiology.

    abstract::Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are global epidemics incurring significant morbidity and mortality. The combination presents many diagnostic challenges. Clinical symptoms and signs frequently overlap. Evaluation of cardiac and pulmonary function is often problematic and occasionally...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1093/eurjhf/hfn013

    authors: Hawkins NM,Petrie MC,Jhund PS,Chalmers GW,Dunn FG,McMurray JJ

    更新日期:2009-02-01 00:00:00

  • Heart rate following short-term beta-blocker titration predicts all-cause mortality in elderly chronic heart failure patients: insights from the CIBIS-ELD trial.

    abstract:AIMS:Beta-blockers (BBs) improve outcomes in heart failure. Results from the Cardiac Insufficiency Bisoprolol Study in Elderly (CIBIS-ELD) trial previously demonstrated the feasibility of heart rate, not maximum dose, as a treatment goal. In this pre-specified analysis, we investigated the prognostic value of achieved ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/ejhf.121

    authors: Düngen HD,Musial-Bright L,Inkrot S,Apostolović S,Edelmann F,Lainščak M,Sekularac N,Störk S,Tahirovic E,Tscholl V,Krackhardt F,Loncar G,Trippel TD,Gelbrich G

    更新日期:2014-08-01 00:00:00

  • Annual rates of admission and seasonal variations in hospitalizations for heart failure.

    abstract:AIMS:To investigate the annual hospitalization rate and seasonal variation in confirmed heart failure (HF) admissions. METHODS AND RESULTS:Records from all admissions to one hospital during 1 year with a HF diagnostic code were reviewed. From 1953 admissions, 595 were excluded because they did not fulfill the diagnost...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(02)00116-2

    authors: Martínez-Sellés M,García Robles JA,Prieto L,Serrano JA,Muñoz R,Frades E,Almendral J

    更新日期:2002-12-01 00:00:00

  • Frequent non-cardiac comorbidities in patients with chronic heart failure.

    abstract::Heart failure (HF) in elderly patients is associated with more diffuse symptoms and signs due to the presence of other noncardiac comorbidities. This can cause difficulties in assessing the correct diagnosis and initiating appropriate therapy. The four most frequently occurring noncardiac comorbidities and therapies u...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejheart.2005.01.008

    authors: Dahlström U

    更新日期:2005-03-16 00:00:00

  • Fluid loss, venous congestion, and worsening renal function in acute decompensated heart failure.

    abstract:AIMS:To investigate the relationship between decongestion, central venous pressure, and risk of worsening renal function (WRF) in patients with acute decompensated heart failure (ADHF). METHODS AND RESULTS:We studied 475 patients with ADHF, of whom 238 underwent right heart catheterization. Right atrial pressure (RAP)...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurjhf/hft036

    authors: Aronson D,Abassi Z,Allon E,Burger AJ

    更新日期:2013-06-01 00:00:00

  • Relation of atrial natriuretic peptides to left ventricular systolic and diastolic function in heart failure.

    abstract:BACKGROUND:Plasma concentrations of atrial natriuretic peptides are correlated with atrial pressures, as are left ventricular ejection fraction and left ventricular filling abnormalities. AIMS:This study investigated the relation of atrial natriuretic peptides to both left ventricular systolic and diastolic function i...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(98)00005-1

    authors: Wijbenga AA,Balk AH,Jonkman FA,Boomsma F,Simoons ML,Man in t Veld AJ

    更新日期:1999-03-01 00:00:00

  • Levosimendan improves renal function in acute decompensated heart failure: possible underlying mechanisms.

    abstract:AIMS:The cardio-renal syndrome plays a critical role in acute heart failure (HF). Levosimendan, an inodilator drug, has a positive but controversial effect on kidney. Our aim was to evaluate its effects on both renal and systemic haemodynamic parameters as well as on renal function, explaining the possible mechanisms i...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/ejhf.9

    authors: Fedele F,Bruno N,Brasolin B,Caira C,D'Ambrosi A,Mancone M

    更新日期:2014-03-01 00:00:00

  • Plasma B-type natriuretic peptide and anti-inflammatory cytokine interleukin-10 levels predict adverse clinical outcome in chronic heart failure patients with depressive symptoms: a 1-year follow-up study.

    abstract:AIMS:To assess the prognostic value of a wide spectrum of neurohormonal and inflammatory markers along with functional status and exercise capacity, in hospitalized chronic heart failure (CHF) patients with depressive symptoms. METHODS AND RESULTS:A total of 300 consecutive hospitalized CHF patients were screened for ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfp125

    authors: Parissis JT,Farmakis D,Nikolaou M,Birmpa D,Bistola V,Paraskevaidis I,Ikonomidis I,Gaitani S,Venetsanou K,Filippatos G,Kremastinos DT

    更新日期:2009-10-01 00:00:00

  • Desmin accumulation restrictive cardiomyopathy and atrioventricular block associated with desmin gene defects.

    abstract:BACKGROUND:Primary desminopathies are caused by desmin gene [DES (MIM*125660)] mutations. The clinical spectrum includes pure myopathies, cardiomuscular diseases and cardiomyopathies. Patients with restrictive cardiomyopathy (RCM) plus atrioventricular block (AVB) due to DES defects are frequently unrecognized unless d...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2005.11.003

    authors: Arbustini E,Pasotti M,Pilotto A,Pellegrini C,Grasso M,Previtali S,Repetto A,Bellini O,Azan G,Scaffino M,Campana C,Piccolo G,Viganò M,Tavazzi L

    更新日期:2006-08-01 00:00:00

  • Myocardial gene expression alterations in peripheral blood mononuclear cells of patients with idiopathic dilated cardiomyopathy.

    abstract:AIMS:To assess cardiac gene expression in peripheral blood cells of patients with idiopathic dilated cardiomyopathy (IDCM) and its relationship to echocardiographic left ventricular (LV) function. METHODS AND RESULTS:A complete echocardiographic study and blood sampling were performed in 65 consecutive stable IDCM pat...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfq057

    authors: Kontaraki JE,Parthenakis FI,Nyktari EG,Patrianakos AP,Vardas PE

    更新日期:2010-06-01 00:00:00

  • Perceived benefit after participating in positive or negative/neutral heart failure trials: the patients' perspective.

    abstract:BACKGROUND:Clinical trials, the gold standard for the evaluation of new therapeutic strategies, may prove a drug to be beneficial, harmful or neutral according to its effect on the end-point(s) under study. AIMS:To study the reaction and perspective of the patients participating in a clinical heart failure trial, part...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(00)00151-3

    authors: Yuval R,Uziel K,Gordon N,Merdler A,Khader N,Karkabi B,Flugelman MY,Halon DA,Lewis BS

    更新日期:2001-03-01 00:00:00

  • Heart failure update.

    abstract::The RUSSLAN study, which randomised 504 patients with post-infarction heart failure in whom intravenous inotropic support might be deemed appropriate, was presented for the first time in a hotline session at the annual meeting of the Working Group on Heart Failure of the European Society of Cardiology. The study sugge...

    journal_title:European journal of heart failure

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s1388-9842(99)00040-9

    authors: Gomes UC,Cleland JG

    更新日期:1999-08-01 00:00:00

  • A Rapid Access Heart Failure Clinic provides a prompt diagnosis and appropriate management of new heart failure presenting in the community.

    abstract:BACKGROUND AND AIMS:The diagnosis of heart failure is an important clinical problem and yet reported diagnostic accuracy in primary care is less than 50%. We established a Rapid Access Heart Failure Clinic (RAHFC) in a district general hospital serving a population of 292,000 in SE London, UK, to diagnose and manage ne...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(00)00108-2

    authors: Fox KF,Cowie MR,Wood DA,Coats AJ,Poole-Wilson PA,Sutton GC

    更新日期:2000-12-01 00:00:00

  • Elevated circulating levels of thioredoxin and stress in chronic heart failure.

    abstract:BACKGROUND:Chronic heart failure (CHF) is a complex syndrome, in which reactive oxygen species and inflammatory cytokines are important stressors that contribute to the pathogenesis. AIM:We have studied physiological stress response parameters in CHF, in particular the redox-active regulator thioredoxin. SUBJECTS:A c...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2004.03.003

    authors: Jekell A,Hossain A,Alehagen U,Dahlström U,Rosén A

    更新日期:2004-12-01 00:00:00

  • Heart failure and sleep apnoea: to sleep perchance to dream.

    abstract::Heart failure and sleep apnoea are major health problems with an increasingly recognized association; evidence suggests that sleep apnoea may play a role in the progression of heart failure. However, confounding factors such as obesity, hypertension and coronary heart disease make this relationship uncertain and an in...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejheart.2005.07.013

    authors: Ferreira S,Winck J,Bettencourt P,Rocha-Goncalves F

    更新日期:2006-05-01 00:00:00

  • Transcatheter treatment of heart failure with preserved or mildly reduced ejection fraction using a novel interatrial implant to lower left atrial pressure.

    abstract:BACKGROUND:Heart failure with preserved or mildly reduced ejection fraction (HFpEF) is common and, to date, therapeutic options are limited. Increased left atrial pressure is a key contributor to the symptoms associated with HFpEF, particularly during physical activity. We report the 30-day outcome of patients treated ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.111

    authors: Søndergaard L,Reddy V,Kaye D,Malek F,Walton A,Mates M,Franzen O,Neuzil P,Ihlemann N,Gustafsson F

    更新日期:2014-07-01 00:00:00