Clinical trials update from the European Society of Cardiology: CHARM, BASEL, EUROPA and ESTEEM.

Abstract:

:This article contains a series of reports on recent research developments in the field of heart failure. Reports of key presentations made at the European Society of Cardiology meeting, held in Vienna, Austria, between 30 August and 3 September 2003 are reported. In the CHARM study, candesartan reduced cardiovascular deaths and hospital admissions for heart failure, both in patients who were already taking an ACE-inhibitor and in those who were ACE intolerant. However, results in patients with preserved left ventricular function were less conclusive. The BASEL study supports the use of B-type natriuretic peptide testing to confirm the diagnosis of heart failure in patients presenting with acute dyspnoea. In EUROPA, the largest ever study of secondary prevention of coronary artery disease, long-term treatment with perindopril reduced the incidence of cardiovascular death, myocardial infarction (MI) and cardiac arrest. The ESTEEM study showed that the oral thrombin inhibitor ximelagatran plus aspirin was more effective than aspirin alone in the prophylaxis of major cardiovascular events following MI.

journal_name

Eur J Heart Fail

authors

Coletta AP,Cleland JG,Freemantle N,Loh H,Memon A,Clark AL

doi

10.1016/s1388-9842(03)00161-2

keywords:

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

697-704

issue

5

eissn

1388-9842

issn

1879-0844

pii

S1388984203001612

journal_volume

5

pub_type

杂志文章
  • Peritoneal dialysis relieves clinical symptoms and is well tolerated in patients with refractory heart failure and chronic kidney disease.

    abstract:AIMS:The aim of the study was to evaluate the efficacy and clinical outcome of peritoneal dialysis (PD) treatment in patients with severe refractory heart failure (HF) and chronic kidney disease (CKD). METHODS AND RESULTS:The PD treatment was performed in 118 patients [49.2% New York Heart Association (NYHA) III and 5...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfs035

    authors: Koch M,Haastert B,Kohnle M,Rump LC,Kelm M,Trapp R,Aker S

    更新日期:2012-05-01 00:00:00

  • Association between loop diuretic dose changes and outcomes in chronic heart failure: observations from the ESC-EORP Heart Failure Long-Term Registry.

    abstract:AIMS:Guidelines recommend down-titration of loop diuretics (LD) once euvolaemia is achieved. In outpatients with heart failure (HF), we investigated LD dose changes in daily cardiology practice, agreement with guideline recommendations, predictors of successful LD down-titration and association between dose changes and...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.1796

    authors: Kapelios CJ,Laroche C,Crespo-Leiro MG,Anker SD,Coats AJS,Díaz-Molina B,Filippatos G,Lainscak M,Maggioni AP,McDonagh T,Mebazaa A,Metra M,Moura B,Mullens W,Piepoli MF,Rosano GMC,Ruschitzka F,Seferovic PM,Lund LH,Heart

    更新日期:2020-08-01 00:00:00

  • Regional pre- and postsynaptic sympathetic system in the failing human heart--regulation of beta ARK-1.

    abstract:OBJECTIVES:Regional presynaptic sympathetic innervation varies considerably in the cardiomyopathic human heart, as shown in previous studies in vivo and in vitro. The goal of the present study was to correlate markers of presynaptic sympathetic innervation with local measurement of the postsynaptic beta-adrenergic syst...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(99)00072-0

    authors: Ungerer M,Weig HJ,Kübert S,Overbeck M,Bengel F,Schömig A,Schwaiger M

    更新日期:2000-03-01 00:00:00

  • Predictors and prognostic impact of recurrent myocardial infarction in patients with left ventricular dysfunction, heart failure, or both following a first myocardial infarction.

    abstract:UNLABELLED:IMS: Recurrent myocardial infarction (MI) is common after a first MI and is associated with increased morbidity and mortality. Predictors and prognosis of a recurrent MI with contemporary management are not well known. METHODS AND RESULTS:We assessed the predictors and prognostic impact of a first recurrent...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurjhf/hfq194

    authors: Thune JJ,Signorovitch JE,Kober L,McMurray JJ,Swedberg K,Rouleau J,Maggioni A,Velazquez E,Califf R,Pfeffer MA,Solomon SD

    更新日期:2011-02-01 00:00:00

  • Early drop in systolic blood pressure and worsening renal function in acute heart failure: renal results of Pre-RELAX-AHF.

    abstract:AIMS:We aimed to determine the relation between baseline systolic blood pressure (SBP), change in SBP, and worsening renal function (WRF) in acute heart failure (AHF) patients enrolled in the Pre-RELAX-AHF trial. METHODS AND RESULTS:The Pre-RELAX-AHF study enrolled 234 patients within 16 h of admission (median 7 h) fo...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurjhf/hfr060

    authors: Voors AA,Davison BA,Felker GM,Ponikowski P,Unemori E,Cotter G,Teerlink JR,Greenberg BH,Filippatos G,Teichman SL,Metra M,Pre-RELAX-AHF study group.

    更新日期:2011-09-01 00:00:00

  • Efficacy of antithrombotic therapy in chronic heart failure: the HELAS study.

    abstract:BACKGROUND:It is not clear if long-term antithrombotic treatment has a beneficial effect on the incidence of thromboembolism in chronic heart failure (CHF). The HELAS study (Heart failure Long-term Antithrombotic Study) is a multicentre, randomised, double-blind, placebo-controlled trial to evaluate antithrombotic trea...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ejheart.2006.02.012

    authors: Cokkinos DV,Haralabopoulos GC,Kostis JB,Toutouzas PK,HELAS investigators.

    更新日期:2006-06-01 00:00:00

  • Impact of lowering pulmonary vascular resistance on right and left ventricular deformation in pulmonary arterial hypertension.

    abstract:AIMS:As pulmonary arterial hypertension (PAH) is associated with significant morbidity and mortality, particularly among patients with right ventricular (RV) dysfunction, we aimed to determine the impact of therapy to reduce pulmonary vascular resistance (PVR) on RV and LV deformation in PAH. METHODS AND RESULTS:Right...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/ejhf.177

    authors: Querejeta Roca G,Campbell P,Claggett B,Vazir A,Quinn D,Solomon SD,Shah AM

    更新日期:2015-01-01 00:00:00

  • A prognostic index to predict long-term mortality in patients with mild to moderate chronic heart failure stabilised on angiotensin converting enzyme inhibitors.

    abstract:BACKGROUND:Mortality in patients with mild to moderate chronic heart failure remains high. At present there is no easy way of identifying patients within this population at increased risk of death in the medium to long term. AIMS:To develop a prognostic index to identify outpatients with mild to moderate chronic heart...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(03)00053-9

    authors: Kearney MT,Nolan J,Lee AJ,Brooksby PW,Prescott R,Shah AM,Zaman AG,Eckberg DL,Lindsay HS,Batin PD,Andrews R,Fox KA

    更新日期:2003-08-01 00:00:00

  • Efficacy of a homeopathic Crataegus preparation compared with usual therapy for mild (NYHA II) cardiac insufficiency: results of an observational cohort study.

    abstract:OBJECTIVES:To compare the efficacy of the homeopathic Crataegus preparation Cralonin for non-inferiority to standard treatment for mild cardiac insufficiency. METHODS:Multicentre non-randomised cohort study in patients aged 50-75 years in New York Heart Association class II. Patients received Cralonin (n=110) or ACE i...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究

    doi:10.1016/s1388-9842(02)00237-4

    authors: Schröder D,Weiser M,Klein P

    更新日期:2003-06-01 00:00:00

  • Combining the ventilatory response to exercise and peak oxygen consumption is no better than peak oxygen consumption alone in predicting mortality in chronic heart failure.

    abstract:BACKGROUND:A low peak oxygen uptake (pVO(2)) and steep VE/VCO(2) slope are independently associated with a worse prognosis in patients with chronic heart failure (CHF). We wished to confirm whether combining these variables as a ratio would lead to a more accurate predictor of prognosis than using either alone. METHOD...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2007.10.010

    authors: Ingle L,Witte KK,Cleland JG,Clark AL

    更新日期:2008-01-01 00:00:00

  • A randomized trial of the addition of home-based exercise to specialist heart failure nurse care: the Birmingham Rehabilitation Uptake Maximisation study for patients with Congestive Heart Failure (BRUM-CHF) study.

    abstract:AIMS:Supervised exercise can benefit selected patients with heart failure, however the effectiveness of home-based exercise remains uncertain. We aimed to assess the effectiveness of a home-based exercise programme in addition to specialist heart failure nurse care. METHODS AND RESULTS:This was a randomized controlled...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurjhf/hfn029

    authors: Jolly K,Taylor RS,Lip GY,Davies M,Davis R,Mant J,Singh S,Greenfield S,Ingram J,Stubley J,Bryan S,Stevens A

    更新日期:2009-02-01 00:00:00

  • Left atrial structure and function and the risk of death or heart failure in atrial fibrillation.

    abstract:AIMS:The present study aimed to assess the association between left atrial (LA) structure and function and the risk for cardiovascular (CV) death or heart failure (HF) hospitalization in a population with atrial fibrillation (AF). METHODS AND RESULTS:In a prospective echocardiographic substudy of the Effective Anticoa...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/ejhf.1606

    authors: Inciardi RM,Giugliano RP,Claggett B,Gupta DK,Chandra A,Ruff CT,Antman EM,Mercuri MF,Grosso MA,Braunwald E,Solomon SD,ENGAGE AF-TIMI 48 Investigators.

    更新日期:2019-12-01 00:00:00

  • Which patients with heart failure should receive specialist palliative care?

    abstract:AIMS:We investigated which patients with heart failure (HF) should receive specialist palliative care (SPC) by first creating a definition of need for SPC in patients hospitalised with HF using patient-reported outcome measures (PROMs) and then testing this definition using the outcome of days alive and out of hospital...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.1240

    authors: Campbell RT,Petrie MC,Jackson CE,Jhund PS,Wright A,Gardner RS,Sonecki P,Pozzi A,McSkimming P,McConnachie A,Finlay F,Davidson P,Denvir MA,Johnson MJ,Hogg KJ,McMurray JJV

    更新日期:2018-09-01 00:00:00

  • Effect of atrial natriuretic peptide on adiponectin in patients with heart failure.

    abstract:BACKGROUND:The adipocyte-specific cytokine adiponectin, has cardioprotective effects, correlates with endogenous cardiac natriuretic peptides and adipocyte has guanylyl cyclase-A receptors of natriuretic peptides. AIMS:To evaluate the effect of carperitide (atrial natriuretic peptide; ANP) on plasma adiponectin in pat...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ejheart.2008.02.005

    authors: Tanaka T,Tsutamoto T,Sakai H,Nishiyama K,Fujii M,Yamamoto T,Horie M

    更新日期:2008-04-01 00:00:00

  • Experience of commencing Carvedilol in elderly patients with heart failure in a routine outpatient clinic.

    abstract::Carvedilol has been shown to be beneficial for patients with heart failure, but it is not clear how it should be initiated in routine clinical practice, particularly in the elderly. This study is a retrospective review of 19 patients of age 80+/-4 years with heart failure, who had Carvedilol treatment initiated in a r...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(00)00092-1

    authors: Owen A

    更新日期:2000-09-01 00:00:00

  • The dynamic assessment of right-ventricular function and its relation to exercise capacity in heart failure.

    abstract:AIMS:To evaluate right-ventricular (RV) function during stress echocardiography (SE) and to assess its relationship with exercise capacity in heart failure (HF) patients. METHODS AND RESULTS:We included 88 patients aged 60.9 +/- 11.2 years with a mean LVEF of 27.2 +/- 9.5%. The following RV parameters were measured at...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfp200

    authors: Rubis P,Podolec P,Kopec G,Olszowska M,Tracz W

    更新日期:2010-03-01 00:00:00

  • Role of beta-blockers in patients admitted for worsening heart failure in a real world setting: data from the Italian Survey on Acute Heart Failure.

    abstract:AIMS:Randomized trials have shown that beta-blockers (BBs) reduce mortality in chronic heart failure (HF). Less data are available on the role of BBs in patients with acute HF, specifically if BBs should be continued or temporarily withdrawn. The aim of this study was to evaluate the role of BBs on in-hospital outcomes...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfn008

    authors: Orso F,Baldasseroni S,Fabbri G,Gonzini L,Lucci D,D'Ambrosi C,Gobbi M,Lecchi G,Randazzo S,Masotti G,Tavazzi L,Maggioni AP,Italian Survey on Acute Heart Failure Investigators.

    更新日期:2009-01-01 00:00:00

  • Heart failure in a multiethnic population in Kuala Lumpur, Malaysia.

    abstract:BACKGROUND:There are established differences in cardiovascular disease in different racial groups. Worldwide, the literature regarding the clinical epidemiology of congestive heart failure (CHF) in non-white populations is scarce. OBJECTIVES:To document the prevalence of CHF in the multiracial population of Malaysia, ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(03)00013-8

    authors: Chong AY,Rajaratnam R,Hussein NR,Lip GY

    更新日期:2003-08-01 00:00:00

  • Heart failure and sleep apnoea: to sleep perchance to dream.

    abstract::Heart failure and sleep apnoea are major health problems with an increasingly recognized association; evidence suggests that sleep apnoea may play a role in the progression of heart failure. However, confounding factors such as obesity, hypertension and coronary heart disease make this relationship uncertain and an in...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1016/j.ejheart.2005.07.013

    authors: Ferreira S,Winck J,Bettencourt P,Rocha-Goncalves F

    更新日期:2006-05-01 00:00:00

  • 'Hospital at home' care model as an effective alternative in the management of decompensated chronic heart failure.

    abstract:AIMS:The 'Hospital at home' (HaH) model avoids hospital admission by transferring healthcare and treatment to the patient's home. We aimed to compare the effectiveness and direct healthcare costs of treating elderly patients with decompensated heart failure (HF) using HaH care vs. inpatient hospital care (IHC) in a car...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurjhf/hfp143

    authors: Mendoza H,Martín MJ,García A,Arós F,Aizpuru F,Regalado De Los Cobos J,Belló MC,Lopetegui P,Cia JM

    更新日期:2009-12-01 00:00:00

  • Perceived benefit after participating in positive or negative/neutral heart failure trials: the patients' perspective.

    abstract:BACKGROUND:Clinical trials, the gold standard for the evaluation of new therapeutic strategies, may prove a drug to be beneficial, harmful or neutral according to its effect on the end-point(s) under study. AIMS:To study the reaction and perspective of the patients participating in a clinical heart failure trial, part...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(00)00151-3

    authors: Yuval R,Uziel K,Gordon N,Merdler A,Khader N,Karkabi B,Flugelman MY,Halon DA,Lewis BS

    更新日期:2001-03-01 00:00:00

  • A Rapid Access Heart Failure Clinic provides a prompt diagnosis and appropriate management of new heart failure presenting in the community.

    abstract:BACKGROUND AND AIMS:The diagnosis of heart failure is an important clinical problem and yet reported diagnostic accuracy in primary care is less than 50%. We established a Rapid Access Heart Failure Clinic (RAHFC) in a district general hospital serving a population of 292,000 in SE London, UK, to diagnose and manage ne...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/s1388-9842(00)00108-2

    authors: Fox KF,Cowie MR,Wood DA,Coats AJ,Poole-Wilson PA,Sutton GC

    更新日期:2000-12-01 00:00:00

  • Left ventricular SERCA2a gene down-regulation does not parallel ANP gene up-regulation during post-MI remodelling in rats.

    abstract:BACKGROUND:In most animal models of chronic hemodynamic overload of the left ventricle (LV) as well as in human end stage heart failure, the sarcoplasmic reticulum (SR) Ca2+-ATPase (SERCA2a) mRNA levels are decreased in parallel with increased atrial natriuretic peptide (ANP) mRNA levels. The situation in the remote my...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2004.10.007

    authors: Prunier F,Chen Y,Gellen B,Heimburger M,Choqueux C,Escoubet B,Michel JB,Mercadier JJ

    更新日期:2005-08-01 00:00:00

  • Phosphodiesterase 5 inhibition protects against increased intra-abdominal pressure-induced renal dysfunction in experimental congestive heart failure.

    abstract:AIMS:Congestive heart failure (CHF) is associated with impaired renal function. Previously, we have demonstrated that rats with decompensated CHF exhibited exaggerated sensitivity to the adverse renal effects of increased increased intra-abdominal pressure (IAP) as compared with normal controls. This study tested wheth...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfs102

    authors: Bishara B,Abu-Saleh N,Awad H,Ghrayeb N,Goltsman I,Aronson D,Khamaysi I,Assady S,Armaly Z,Haddad S,Haddad E,Abassi Z

    更新日期:2012-10-01 00:00:00

  • LCZ696, an angiotensin receptor-neprilysin inhibitor, improves cardiac function with the attenuation of fibrosis in heart failure with reduced ejection fraction in streptozotocin-induced diabetic mice.

    abstract:AIMS:Angiotensin receptor-neprilysin inhibitors (ARNis) acts an ARB and neprilysin inhibitor. Diabetes mellitus significantly increases the risk of cardiovascular disease and heart failure (HF). Therefore, we evaluated the effects and mechanisms of ARNi in HF with reduced ejection fraction (HFrEF) in streptozotocin-ind...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.474

    authors: Suematsu Y,Miura S,Goto M,Matsuo Y,Arimura T,Kuwano T,Imaizumi S,Iwata A,Yahiro E,Saku K

    更新日期:2016-04-01 00:00:00

  • A functional variant of the neuropeptide S receptor-1 gene modulates clinical outcomes and healthcare utilization in patients with systolic heart failure: results from the Interdisciplinary Network Heart Failure (INH) Study.

    abstract:AIMS:Psychopathologies may occur in heart failure (HF) and can be associated with adverse outcomes. Amongst neuropeptide S receptor gene functional sequence variants, the T-allele [asparagine(107)isoleucine, NPSR1 rs324981] has been identified as a risk factor for increased anxiety/overinterpretation of bodily symptoms...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.706

    authors: Angermann CE,Kaspar M,Marx A,Kittel-Schneider S,Menhofer D,Störk S,Ertl G,Domschke K,Deckert J,Reif A

    更新日期:2017-03-01 00:00:00

  • Bi treatment with hydralazine/nitrates vs. placebo in Africans admitted with acute HEart Failure (BA-HEF).

    abstract:AIMS:Patients with acute heart failure (HF) in Africa are rarely being treated with a hydralazine/nitrates combination. Therefore the effect of this treatment was studied here. METHODS AND RESULTS:The study was planned to enrol 500 patients during an acute HF admission, from nine sub-Saharan African countries. Patient...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/ejhf.581

    authors: Sliwa K,Damasceno A,Davison BA,Mayosi BM,Sani MU,Ogah O,Mondo C,Ojji D,Dzudie A,Kouam CK,Yonga G,Ba SA,Ogola E,Edwards C,Milo O,Cotter G

    更新日期:2016-10-01 00:00:00

  • Oral glucose tolerance testing in an outpatient heart failure clinic reveals a high proportion of undiagnosed diabetic patients with an adverse prognosis.

    abstract:AIMS:We evaluated the applicability and prognostic importance of oral glucose tolerance testing (OGTT) among outpatients with systolic heart failure (SHF). METHODS AND RESULTS:Consecutive patients with SHF and left ventricular ejection fraction (LVEF) ≤ 45% referred to a heart failure clinic (n= 413) were included in ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfq216

    authors: Egstrup M,Schou M,Gustafsson I,Kistorp CN,Hildebrandt PR,Tuxen CD

    更新日期:2011-03-01 00:00:00

  • Comparison of myocardial deformation and velocity dyssynchrony for identification of responders to cardiac resynchronization therapy.

    abstract:AIMS:It is unclear whether myocardial velocity or deformation indices of dyssynchrony are better at predicting response to cardiac resynchronization therapy (CRT). Therefore, two indices of left ventricular (LV) dyssynchrony based on myocardial velocity and deformation were compared to predict success of CRT. METHODS ...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurjhf/hfp032

    authors: Mele D,Toselli T,Capasso F,Stabile G,Piacenti M,Piepoli M,Giatti S,Klersy C,Sallusti L,Ferrari R

    更新日期:2009-04-01 00:00:00

  • Relationship between right ventricular volumes measured by cardiac magnetic resonance imaging and prognosis in patients with chronic heart failure.

    abstract:AIMS:The aim of this study was to investigate the prognostic impact of right ventricular (RV) size in patients with chronic heart failure. METHODS AND RESULTS:Normal volunteers (n = 80) and patients (n = 380) with left ventricular (LV) ejection fraction <45% on echocardiography and on optimal treatment for heart failu...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfq161

    authors: Bourantas CV,Loh HP,Bragadeesh T,Rigby AS,Lukaschuk EI,Garg S,Tweddel AC,Alamgir FM,Nikitin NP,Clark AL,Cleland JG

    更新日期:2011-01-01 00:00:00