Abstract:
BACKGROUND:Patients presenting to the emergency department (ED) with acute heart failure (AHF) are at an increased risk of morbidity and mortality. The electrocardiogram (ECG) is a routine investigation in patients with AHF used to identify potential causes and/or complications. It is unclear whether 12-lead ECG characteristics can serve as a prognostic indicator in this population. METHODS AND RESULTS:Patients with AHF from four hospital EDs were prospectively enrolled into the AHF - Emergency Management cohort. In addition to baseline data collection, the first available ECG was read in a core laboratory. Clinical outcomes (all-cause mortality and readmission) were recorded and risk models were developed. Of 937 enrolled patients, 816 had a diagnosis of AHF and an available ECG. Median age of the population was 77 [interquartile range (IQR) 67-85], 47% were female and median ejection fraction was 45% (IQR 30-55). Abnormalities were common, with only 7.5% of patients having a normal ECG. During the median follow-up of 25.7 months, there were 379 (46%) all-cause deaths and 328 (40%) hospital readmissions. Sinus rhythm was associated with better outcomes [hazard ratio (HR) 0.76; 95% confidence interval (CI) 0.62, 0.94], while paced rhythms (HR 1.51, 95% CI 1.11, 2.05), a wide QRS (HR 1.29, 95% CI 1.04, 1.59) and an ECG with any abnormality (HR 1.57, 95% CI 1.01, 2.44) was associated with poorer outcomes. Other individual ECG characteristics were not related to clinical outcomes after risk adjustment. CONCLUSIONS:Certain ECG abnormalities are common in patients with AHF and associated with poor outcomes. Used in conjunction with other clinical variables, the ECG may be a useful tool in long-term risk stratifying patients.
journal_name
Eur J Heart Failjournal_title
European journal of heart failureauthors
Gouda P,Brown P,Rowe BH,McAlister FA,Ezekowitz JAdoi
10.1002/ejhf.561subject
Has Abstractpub_date
2016-08-01 00:00:00pages
1032-40issue
8eissn
1388-9842issn
1879-0844journal_volume
18pub_type
杂志文章abstract:AIMS:To investigate the prevalence of iron deficiency (ID) in heart failure (HF) patients with normal vs. abnormal red cell indices (RCI), the associations between iron parameters and RCI, and prognostic consequences of ID independently of RCI. METHODS AND RESULTS:We analysed clinical data of 1821 patients with HF [me...
journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究
doi:10.1002/ejhf.820
更新日期:2018-01-01 00:00:00
abstract:AIMS:To assess cardiac gene expression in peripheral blood cells of patients with idiopathic dilated cardiomyopathy (IDCM) and its relationship to echocardiographic left ventricular (LV) function. METHODS AND RESULTS:A complete echocardiographic study and blood sampling were performed in 65 consecutive stable IDCM pat...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1093/eurjhf/hfq057
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Patients with chronic heart failure (CHF) have frequent episodes of exacerbation leading to recurrent hospitalization. AIMS:To explore factors related to patients seeking care for worsening CHF. METHODS:Eighty-eight patients diagnosed with a deteriorating CHF condition were interviewed. Data were analysed ...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2006.11.002
更新日期:2007-06-01 00:00:00
abstract::COMBAT is a prospective, multicenter, randomized, blinded clinical study, with crossover design. The main objective is the comparative evaluation of atrio-biventricular versus conventional atrioventricular stimulation (atrio and right ventricle) in patients with heart failure and bradycardia as the primary indication ...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2004.06.008
更新日期:2005-03-02 00:00:00
abstract:AIMS:Patients with intestinal malabsorption may develop cardiac dysfunction the origin of which is often unclear. We sought to investigate the pathogenesis of dilated cardiomyopathy in human malabsorption. METHODS AND RESULTS:Eighteen patients with intestinal bypass as treatment for severe obesity and cardiomyopathy u...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1093/eurjhf/hfr167
更新日期:2012-02-01 00:00:00
abstract:AIMS:The most recent European guidelines have proposed new definitions of pulmonary hypertension (PH) in left heart disease, to better approach the characteristics required to reflect the presence of pulmonary vascular disease. The purpose of this study was to assess whether different haemodynamic definitions of post-c...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.1067
更新日期:2018-04-01 00:00:00
abstract::Heart rate not only predicts outcome but may also be a therapeutic target in patients with chronic heart failure. Several classes of pharmacological agents can be used to modulate heart rate, including beta-blockers, ivabradine, digoxin, amiodarone, and verapamil. Choice of agent will depend on heart rhythm, co-morbid...
journal_title:European journal of heart failure
pub_type: 杂志文章,评审
doi:10.1093/eurjhf/hft129
更新日期:2014-01-01 00:00:00
abstract:AIMS:Severe heart failure (HF) is often associated with cachexia that reverses post-heart transplantation (HTx) with frequent development of obesity. Ghrelin is a novel appetite-stimulating hormone. The aim was to determine the role of ghrelin in regulating appetite, food intake, and body composition in HF and post-HTx...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1093/eurjhf/hfp088
更新日期:2009-08-01 00:00:00
abstract:AIMS:To examine the current status of care and needs of adult congenital heart disease (ACHD) services in the Central and South Eastern European (CESEE) region. METHODS AND RESULTS:We obtained data regarding the national ACHD status for 19 CESEE countries from their ACHD representative based on an extensive survey for...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.2040
更新日期:2020-11-02 00:00:00
abstract:BACKGROUND:Beneficial effects of left ventricular (LV)-based pacing on acute hemodynamic parameters were reported in several series, but only a few studies examined the long-term effects of this new pacing procedure. AIMS:To assess long-term effects of permanent LV-based pacing on LV function and mitral regurgitation ...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/s1388-9842(01)00145-3
更新日期:2001-08-01 00:00:00
abstract::Appropriate interpretation of changes in markers of kidney function is essential during the treatment of acute and chronic heart failure. Historically, kidney function was primarily assessed by serum creatinine and the calculation of estimated glomerular filtration rate. An increase in serum creatinine, also termed wo...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.1697
更新日期:2020-04-01 00:00:00
abstract:AIMS:Plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) is a strong biochemical marker of heart failure and left ventricular dysfunction (LVD). Due to renal arterio-venous clearance of NT-proBNP and the correlation of plasma concentrations with renal function, we hypothesized that NT-proBNP may have potential ...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1093/eurjhf/hfq016
更新日期:2010-04-01 00:00:00
abstract:AIMS:To characterise the prevalence, in-hospital complications, management, and long-term outcome of patients with congestive heart failure but preserved left ventricular systolic function after acute myocardial infarction. METHODS:3166 consecutive patients screened for entry in the Bucindolol Evaluation in Acute Myoc...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/s1388-9842(03)00159-4
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND AND AIM:The choice of optimal treatment strategy in patients with coronary artery disease (CAD) and severe left ventricular (LV) dysfunction is often difficult. The aim of this study was to compare long-term results of patients with chronic CAD, severe heart failure and a defined scope of myocardial viabilit...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/s1388-9842(02)00089-2
更新日期:2003-01-01 00:00:00
abstract::It is well known that atrial fibrillation can lead to heart failure, and is attributed to rapid ventricular rate (tachycardia-induced cardiomyopathy). Some recent studies suggest the possible existence of an intrinsic left-ventricular factor related to atrial fibrillation, irrespective of other elements. In order to d...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/s1388-9842(02)00004-1
更新日期:2002-06-01 00:00:00
abstract:UNLABELLED:Experimental data have shown that rIL2 has negative inotropic properties. This has not been investigated in humans with normal left ventricular function. Seventeen consecutive renal cell carcinoma patients who received rIL2 therapy because of dissemination were analyzed before and after treatment with a low ...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/s1388-9842(00)00073-8
更新日期:2000-06-01 00:00:00
abstract:BACKGROUND:Hereditary hemochromatosis (HH), a common autosomal recessive disease, leads to excessive iron accumulation in some organs, including the heart. It is therefore not surprising that cardiomyopathy is one of the most severe complications of HH. The HFE gene defects have been thought to contribute to idiopathic...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2004.03.007
更新日期:2005-01-01 00:00:00
abstract:AIMS:Peripheral muscle dysfunction is a key mechanism contributing to exercise intolerance (i.e. breathlessness and fatigue) in heart failure patients with preserved ejection fraction (HFpEF); however, the underlying molecular and cellular mechanisms remain unknown. We therefore used an animal model to elucidate potent...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.239
更新日期:2015-03-01 00:00:00
abstract::The vast majority of acute heart failure episodes are characterized by increasing symptoms and signs of congestion with volume overload. The goal of therapy in those patients is the relief of congestion through achieving a state of euvolaemia, mainly through the use of diuretic therapy. The appropriate use of diuretic...
journal_title:European journal of heart failure
pub_type: 杂志文章,评审
doi:10.1002/ejhf.1369
更新日期:2019-02-01 00:00:00
abstract:AIMS:To examine the impact of diabetes mellitus on long-term clinical outcomes in patients with myocardial infarction (MI) complicated by clinical signs of heart failure (HF) or left ventricular dysfunction (LVD). METHODS AND RESULTS:The High-Risk MI Database consists of individual data from 28 771 patients and was cr...
journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究
doi:10.1002/ejhf.797
更新日期:2017-05-01 00:00:00
abstract:AIMS:Heart failure (HF) patients with a mid-range ejection fraction (HFmrEF) are not well characterized. Accordingly, we examined the epidemiology, pathophysiology and clinical outcomes of HF patients with a left ventricular ejection fraction (LVEF) of 40-50%. METHODS AND RESULTS:We identified 168 patients with an LVE...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.879
更新日期:2017-12-01 00:00:00
abstract:AIMS:The proteasome prevents the intracellular accumulation of proteins and its impairment can lead to structural and functional alterations, as noted for the coronary vasculature in a previous study. Utilizing the same model, this study was designed to test the hypothesis that chronic proteasome inhibition (PSI) also ...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1093/eurjhf/hft034
更新日期:2013-06-01 00:00:00
abstract:AIMS:Heart failure (HF) with normal or preserved left ventricular (LV) ejection fraction (HFPEF) has been reported to be associated with similar outcome as HF with reduced EF (HFREF) in registry-based and epidemiological analyses, but many of these studies excluded patients who did not have EF measurements. Conversely,...
journal_title:European journal of heart failure
pub_type: 杂志文章,meta分析
doi:10.1093/eurjhf/hfp103
更新日期:2009-09-01 00:00:00
abstract:AIMS:The goal of the study was to examine the prognostic impact, haemodynamic and clinical features associated with lung congestion in patients with chronic heart failure (HF). METHODS AND RESULTS:HF patients (n = 186) and HF-free controls (n = 21) underwent right heart catheterization, echocardiography, pulmonary fun...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.417
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:The adipocyte-specific cytokine adiponectin, has cardioprotective effects, correlates with endogenous cardiac natriuretic peptides and adipocyte has guanylyl cyclase-A receptors of natriuretic peptides. AIMS:To evaluate the effect of carperitide (atrial natriuretic peptide; ANP) on plasma adiponectin in pat...
journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ejheart.2008.02.005
更新日期:2008-04-01 00:00:00
abstract:AIMS:Brain natriuretic peptide (BNP), NT-proBNP and troponins are useful for the assessment of patients with heart failure. Few data exist about their serial changes and their prognostic value in patients with acute heart failure (AHF). METHODS AND RESULTS:NT-proBNP and troponin-T plasma levels were measured at baseli...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2007.05.007
更新日期:2007-08-01 00:00:00
abstract:OBJECTIVE:To achieve angiogenic interaction between VEGF(165) and angiopoietin-1 (Ang-1) using a novel adenoviral bicistronic vector (Ad-Bic) encoding the two factors and delivered ex vivo using sex-mismatched human skeletal myoblasts. METHODS AND RESULTS:A myocardial infarction model was developed in 29 female pigs; ...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2006.04.008
更新日期:2007-01-01 00:00:00
abstract:AIMS:Rho kinases (ROCKs) are the best characterized effectors of the small G-protein RhoA, and play a role in enhanced vasoconstriction in animal models of congestive heart failure (CHF). This study examined if ROCK activity is increased in CHF and how it is associated with the outcome in CHF. METHODS AND RESULTS:Pati...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1093/eurjhf/hfs068
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND AND AIMS:Sleep disordered breathing (SDB), especially Cheyne-Stokes respiration (CSR) is common in patients with chronic heart failure (CHF). Adaptive servoventilation (ASV) was recently introduced to treat CSR in CHF. The aim of this study was to investigate the effects of ASV on CSR and CHF parameters. ME...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2008.04.007
更新日期:2008-06-01 00:00:00
abstract:AIMS:The 'Hospital at home' (HaH) model avoids hospital admission by transferring healthcare and treatment to the patient's home. We aimed to compare the effectiveness and direct healthcare costs of treating elderly patients with decompensated heart failure (HF) using HaH care vs. inpatient hospital care (IHC) in a car...
journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
doi:10.1093/eurjhf/hfp143
更新日期:2009-12-01 00:00:00