[123I]-phenylpentadecanoic acid uptake in patients with dilated cardiomyopathy.

Abstract:

BACKGROUND:The rate constant for global fatty acid influx (k(1)) was studied in 12 male patients with dilated cardiomyopathy (DCM). METHOD:10 normal subjects served as controls. 201-Thallium (201TI) and [123I]-phenyl-pentadecanoic acid (IPPA) were administered during bicycle exercise under fasting conditions. RESULTS:All patients showed non-homogeneous tracer uptake defects for 201TI and IPPA. k(1) was significantly higher in DCM patients than controls. k(1) showed significant inverse correlation between cardiac index, left-ventricular ejection fraction, left-ventricular enddiastolic pressure and echocardiographic left-ventricular ejection fraction. CONCLUSION:We presume that an increased regional rate constant of IPPA influx into the myocardial tissue in patients with DCM reflects a compensatory mechanism of altered myocardium.

journal_name

Eur J Heart Fail

authors

Miche E,Radzewitz A,Notohamiprodjo G,Baller D,Kloppe A,Eckert S,Gleichmann U

doi

10.1016/s1388-9842(02)00024-7

keywords:

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

431-8

issue

4

eissn

1388-9842

issn

1879-0844

pii

S1388984202000247

journal_volume

4

pub_type

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