Adherence to the medical regime in patients with heart failure.

Abstract:

AIMS:To assess adherence to medical treatment in patients with heart failure (HF) using a specific questionnaire and measurement of the serum concentration of digoxin. METHODS AND RESULTS:Forty patients with symptomatic HF and a clinical indication for digoxin were included in this pilot study. The assessment of adherence to the medical regime was based on two different methods: (i) the CARDIA-Questionnaire and (ii) the measurement of serum digoxin concentration (SDC) at 1 and 6 months. All patients were placed on digoxin treatment (target SDC 0.6-0.8 ng/mL) at baseline. Poor adherence was defined if the patient self-reported taking < or =75% of the prescribed HF medication or had an SDC < 0.4 ng/mL (subtherapeutic range) at the follow-up visits. During the entire follow-up, the proportion of patients with poor adherence was 15% as assessed by the questionnaire, 20% as assessed by the SDC, and 25% if both methods were combined. CONCLUSION:Although HF is a symptomatic disease, the proportion of patients with poor adherence to the medical regime in our study was high (up to 25%). The objective methodology based on the measurement of the SDC identified a higher number of patients with poor adherence when compared with the CARDIA-Questionnaire.

journal_name

Eur J Heart Fail

authors

Muzzarelli S,Brunner-La Rocca H,Pfister O,Foglia P,Moschovitis G,Mombelli G,Stricker H

doi

10.1093/eurjhf/hfq015

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

389-96

issue

4

eissn

1388-9842

issn

1879-0844

pii

hfq015

journal_volume

12

pub_type

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