Left ventricular systolic dysfunction associated with pulmonary hypertension riociguat trial (LEPHT): rationale and design.

abstract：AIM:Mineralocorticoid receptor antagonists (MRAs) improve outcomes in heart failure with reduced ejection fraction (HFrEF), but are underutilized. Hyperkalaemia may be one reason, but the underlying reasons for underuse are unknown. The aim of this study was to investigate the independent predictors of MRA underuse in ...

journal_title：European journal of heart failure

authors： Savarese G,Carrero JJ,Pitt B,Anker SD,Rosano GMC,Dahlström U,Lund LH

更新日期：2018-09-01 00:00:00

abstract：AIMS:Ventricular septal rupture (VSR) became a rare mechanical complication of myocardial infarction in the era of percutaneous coronary interventions but is associated with extreme mortality in patients who present with cardiogenic shock (CS). Promising outcomes have been reported with the use of circulatory support a...

journal_title：European journal of heart failure

authors： Rob D,Špunda R,Lindner J,Rohn V,Kunstýř J,Balík M,Rulíšek J,Kopecký P,Lipš M,Šmíd O,Kovárník T,Mlejnský F,Linhart A,Bělohlávek J

更新日期：2017-05-01 00:00:00

abstract：:Self-care is essential in the long-term management of chronic heart failure. Heart failure guidelines stress the importance of patient education on treatment adherence, lifestyle changes, symptom monitoring and adequate response to possible deterioration. Self-care is related to medical and person-centred outcomes in ...

journal_title：European journal of heart failure

authors： Jaarsma T,Hill L,Bayes-Genis A,La Rocca HB,Castiello T,Čelutkienė J,Marques-Sule E,Plymen CM,Piper SE,Riegel B,Rutten FH,Ben Gal T,Bauersachs J,Coats AJS,Chioncel O,Lopatin Y,Lund LH,Lainscak M,Moura B,Mullens W,P

更新日期：2020-09-18 00:00:00

abstract：BACKGROUND:EMPEROR-Preserved is an ongoing trial evaluating the effect of empagliflozin in patients with heart failure with preserved ejection fraction (HFpEF). This report describes the baseline characteristics of the EMPEROR-Preserved cohort and compares it with patients enrolled in prior HFpEF trials. METHODS:EMPER...

journal_title：European journal of heart failure

authors： Anker SD,Butler J,Filippatos G,Khan MS,Ferreira JP,Bocchi E,Böhm M,Rocca HPB,Choi DJ,Chopra V,Chuquiure E,Giannetti N,Gomez-Mesa JE,Janssens S,Januzzi JL,Gonzalez-Juanatey JR,Merkely B,Nicholls SJ,Perrone SV,Piña IL

更新日期：2020-11-29 00:00:00

abstract：OBJECTIVE:To determine the acute vasodilator effect of sublingual sildenafil in heart transplant candidates with severe pulmonary hypertension due to severe left ventricular dysfunction (LVD). BACKGROUND:Pulmonary hypertension confers an increased risk of early graft failure. PATIENTS AND METHODS:Seven patients, (mea...

journal_title：European journal of heart failure

authors： Angel Gómez-Sánchez M,Saenz De La Calzada C,Escribano Subías P,Francisco Delgado Jiménez J,Lázaro Salvador M,Albarrán González A,Cea Calvo L

更新日期：2004-08-01 00:00:00

abstract：AIMS:Psychopathologies may occur in heart failure (HF) and can be associated with adverse outcomes. Amongst neuropeptide S receptor gene functional sequence variants, the T-allele [asparagine(107)isoleucine, NPSR1 rs324981] has been identified as a risk factor for increased anxiety/overinterpretation of bodily symptoms...

journal_title：European journal of heart failure

authors： Angermann CE,Kaspar M,Marx A,Kittel-Schneider S,Menhofer D,Störk S,Ertl G,Domschke K,Deckert J,Reif A

更新日期：2017-03-01 00:00:00

abstract：BACKGROUND:The use of oral anticoagulation in patients with heart failure in sinus rhythm remains controversial as previous large randomized controlled trials (RCTs) have not shown a survival benefit. However, heterogeneity exists among heart failure patients and it is possible that high-risk subgroups may benefit from...

journal_title：European journal of heart failure

authors： Goudie A,Elder D,Deshmukh H,Szwejkowski BR,Lang CC,George J

更新日期：2015-01-01 00:00:00

abstract：:In the present report we describe that NG-monomethyl-L-arginine acetate, a non-specific nitric oxide synthesis inhibitor, administered at 1 mg kg(-1) h(-1) to a patient with critical hypotension following mitral valve surgery combined with passive containment surgery, increased the urinary output and arterial blood pr...

journal_title：European journal of heart failure

authors： Franco-Cereceda A,Holm P,Bredin F,Adding C

更新日期：2005-12-01 00:00:00

abstract：BACKGROUND:Mortality in patients with mild to moderate chronic heart failure remains high. At present there is no easy way of identifying patients within this population at increased risk of death in the medium to long term. AIMS:To develop a prognostic index to identify outpatients with mild to moderate chronic heart...

journal_title：European journal of heart failure

authors： Kearney MT,Nolan J,Lee AJ,Brooksby PW,Prescott R,Shah AM,Zaman AG,Eckberg DL,Lindsay HS,Batin PD,Andrews R,Fox KA

更新日期：2003-08-01 00:00:00

abstract：AIM:To describe differences in patient characteristics and outcomes by ethnicity in patients with diabetes mellitus (DM) and heart failure (HF) with reduced ejection fraction (HFrEF, ejection fraction ≤35%) in a multi-ethnic cohort. METHODS AND RESULTS:Patient level data from two cohorts (HF-ACTION and ASIAN-HF) were ...

journal_title：European journal of heart failure

authors： Cooper LB,Yap J,Tay WT,Teng TK,MacDonald M,Anand IS,Sharma A,O'Connor CM,Kraus WE,Mentz RJ,Lam CS,HF-ACTION and ASIAN-HF Investigators.

更新日期：2018-09-01 00:00:00

abstract：AIMS:Knowledge of patient preferences is vital for delivering optimal healthcare. This study uses utility measurement to assess the preferences of heart failure (HF) patients regarding quality of life or longevity. The utility approach represents the perspective of a patient; facilitates the combination of mortality, m...

journal_title：European journal of heart failure

authors： Kraai IH,Vermeulen KM,Luttik ML,Hoekstra T,Jaarsma T,Hillege HL

更新日期：2013-10-01 00:00:00

abstract：AIMS:We aimed to determine the relation between baseline systolic blood pressure (SBP), change in SBP, and worsening renal function (WRF) in acute heart failure (AHF) patients enrolled in the Pre-RELAX-AHF trial. METHODS AND RESULTS:The Pre-RELAX-AHF study enrolled 234 patients within 16 h of admission (median 7 h) fo...

journal_title：European journal of heart failure

authors： Voors AA,Davison BA,Felker GM,Ponikowski P,Unemori E,Cotter G,Teerlink JR,Greenberg BH,Filippatos G,Teichman SL,Metra M,Pre-RELAX-AHF study group.

更新日期：2011-09-01 00:00:00

abstract：UNLABELLED:The aim of this study was to evaluate the efficacy of adding the beta-blocker bucindolol to standard therapy shortly after a myocardial infarction in a high-risk population with reduced left ventricular function. METHODS:The study was planned to include 2000 patients with an enzyme confirmed myocardial infa...

journal_title：European journal of heart failure

authors： Torp-Pedersen C,Køber L,Ball S,Hall A,Brendorp B,Ottesen M,Berning J,Jensen G,Hampton J,Zilles P,Eberle S,Carlsen J

更新日期：2002-08-01 00:00:00

abstract：:Heart failure (HF) in elderly patients is associated with more diffuse symptoms and signs due to the presence of other noncardiac comorbidities. This can cause difficulties in assessing the correct diagnosis and initiating appropriate therapy. The four most frequently occurring noncardiac comorbidities and therapies u...

journal_title：European journal of heart failure

authors： Dahlström U

更新日期：2005-03-16 00:00:00

abstract：AIMS:Impaired tissue perfusion is often observed in patients with acute heart failure. We tested whether low-dose nitroglycerin (NTG) improves microcirculatory perfusion in patients admitted for acute heart failure. METHODS AND RESULTS:In 20 acute heart failure patients, NTG was given as intravenous infusion at a fixe...

journal_title：European journal of heart failure

authors： den Uil CA,Lagrand WK,Spronk PE,van der Ent M,Jewbali LS,Brugts JJ,Ince C,Simoons ML

更新日期：2009-04-01 00:00:00

abstract：:The use of Left Ventricular Assist Devices (LVADs) has increased over the last decade because of the lack of healthy donor hearts. In this report we describe for the first time a patient with an LVAD Heart Mate II (HM II) implanted 6 months before admission, who initially suffered from severe anaemia and later on unde...

journal_title：European journal of heart failure

authors： Gogas BD,Parissis JT,Filippatos GS,Iliodromitis EK,Soultanis KC,Kostopanagiotou GG,Theodoropoulos SP,Kremastinos DT,Yacoub MH

更新日期：2009-08-01 00:00:00

abstract：AIMS:The left ventricular phenotype of idiopathic dilated cardiomyopathy (DCM) can appear similar in paediatric and adult patients. However, the aetiology of paediatric DCM is usually idiopathic, and often leads an aggressive clinical course. A structural underpinning of DCM is extracellular matrix changes, which are d...

journal_title：European journal of heart failure

authors： Hsia TY,Ringewald JM,Stroud RE,Forbus GA,Bradley SM,Chung WK,Spinale FG

更新日期：2011-03-01 00:00:00

abstract：AIMS:Left ventricular contractile reserve is a prognostic indicator for adverse outcome in patients with severe chronic heart failure with reduced ejection fraction (HFrEF). We investigated the dobutamine-induced changes of LV multidimensional deformation and their predictive value for cardiac mortality of patients wit...

journal_title：European journal of heart failure

authors： Paraskevaidis IA,Ikonomidis I,Simitsis P,Parissis J,Stasinos V,Makavos G,Lekakis J

更新日期：2017-07-01 00:00:00

abstract：:Carvedilol has been shown to be beneficial for patients with heart failure, but it is not clear how it should be initiated in routine clinical practice, particularly in the elderly. This study is a retrospective review of 19 patients of age 80+/-4 years with heart failure, who had Carvedilol treatment initiated in a r...

journal_title：European journal of heart failure

authors： Owen A

更新日期：2000-09-01 00:00:00

abstract：:Appropriate interpretation of changes in markers of kidney function is essential during the treatment of acute and chronic heart failure. Historically, kidney function was primarily assessed by serum creatinine and the calculation of estimated glomerular filtration rate. An increase in serum creatinine, also termed wo...

journal_title：European journal of heart failure

authors： Mullens W,Damman K,Testani JM,Martens P,Mueller C,Lassus J,Tang WHW,Skouri H,Verbrugge FH,Orso F,Hill L,Ural D,Lainscak M,Rossignol P,Metra M,Mebazaa A,Seferovic P,Ruschitzka F,Coats A

更新日期：2020-04-01 00:00:00

abstract：AIMS:The purpose of this study was to determine the prognostic significance and associated clinical profile of early post-discharge N-terminal pro-B-type natriuretic peptide (NT-proBNP) trajectory among patients hospitalized for worsening chronic heart failure (HHF). METHODS AND RESULTS:This post-hoc analysis of the A...

journal_title：European journal of heart failure

authors： Greene SJ,Maggioni AP,Fonarow GC,Solomon SD,Böhm M,Kandra A,Prescott MF,Reimund B,Hua TA,Lesogor A,Zannad F,Gheorghiade M,ASTRONAUT Investigators and Coordinators.

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:No specific guidelines exist on how to manage renal dysfunction (RD) in patients with chronic heart failure (CHF). AIMS:To identify the proportion of patients with moderate to severe RD and CHF who showed an improvement in their renal function in response to a systematic management algorithm. METHODS:Stabl...

journal_title：European journal of heart failure

authors： de Silva R,Nikitin NP,Witte KK,Rigby AS,Loh H,Nicholson A,Bhandari S,Clark AL,Cleland JG

更新日期：2007-04-01 00:00:00

abstract：AIMS:The 'Hospital at home' (HaH) model avoids hospital admission by transferring healthcare and treatment to the patient's home. We aimed to compare the effectiveness and direct healthcare costs of treating elderly patients with decompensated heart failure (HF) using HaH care vs. inpatient hospital care (IHC) in a car...

journal_title：European journal of heart failure

authors： Mendoza H,Martín MJ,García A,Arós F,Aizpuru F,Regalado De Los Cobos J,Belló MC,Lopetegui P,Cia JM

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Heart failure with preserved or mildly reduced ejection fraction (HFpEF) is common and, to date, therapeutic options are limited. Increased left atrial pressure is a key contributor to the symptoms associated with HFpEF, particularly during physical activity. We report the 30-day outcome of patients treated ...

journal_title：European journal of heart failure

authors： Søndergaard L,Reddy V,Kaye D,Malek F,Walton A,Mates M,Franzen O,Neuzil P,Ihlemann N,Gustafsson F

更新日期：2014-07-01 00:00:00

abstract：AIMS:The aim of this study was to investigate the clinical picture and outcome of cardiogenic shock and to develop a risk prediction score for short-term mortality. METHODS AND RESULTS:The CardShock study was a multicentre, prospective, observational study conducted between 2010 and 2012. Patients with either acute co...

journal_title：European journal of heart failure

authors： Harjola VP,Lassus J,Sionis A,Køber L,Tarvasmäki T,Spinar J,Parissis J,Banaszewski M,Silva-Cardoso J,Carubelli V,Di Somma S,Tolppanen H,Zeymer U,Thiele H,Nieminen MS,Mebazaa A,CardShock Study Investigators.,GREAT network

更新日期：2015-05-01 00:00:00

abstract：:The published version of this paper contained an error. The part C of the figure only has the header "multiple organs", whereas it must read: “HF does not affect multiple organs”. ...

journal_title：European journal of heart failure

authors：

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:The relationship between quality of life (QoL) and survival have been poorly investigated. The aim of this study was to determine the value of QoL score as a prognostic factor in a prospective cohort of patients with advanced chronic heart failure (CHF). METHODS:QoL assessment was performed with a generic q...

journal_title：European journal of heart failure

authors： Alla F,Briançon S,Guillemin F,Juillière Y,Mertès PM,Villemot JP,Zannad F,EPICAL Investigators.

更新日期：2002-06-01 00:00:00

abstract：BACKGROUND AND AIMS:The diagnosis of heart failure is an important clinical problem and yet reported diagnostic accuracy in primary care is less than 50%. We established a Rapid Access Heart Failure Clinic (RAHFC) in a district general hospital serving a population of 292,000 in SE London, UK, to diagnose and manage ne...

journal_title：European journal of heart failure

authors： Fox KF,Cowie MR,Wood DA,Coats AJ,Poole-Wilson PA,Sutton GC

更新日期：2000-12-01 00:00:00

abstract：:Nitric oxide (NO) appears to play a role in modulating cardiac function in both health and disease. Early studies in isolated rodent cardiac myocytes demonstrated a depressant effect of NO supplied by NO donors (exogenous) as well as NO generated within myocytes (endogenous). There is increasing evidence for a functio...

journal_title：European journal of heart failure

authors： Sarkar D,Vallance P,Harding SE

更新日期：2001-10-01 00:00:00

abstract：UNLABELLED:We compare the effectiveness of direct adenoviral angiopoietin-1 (Ad-Ang-1) injection with transplantation of skeletal myoblasts (SkMs) over-expressing angiopoietin-1 (Ang-1) for angiogenic response and improvement of heart function in an experimental porcine model of myocardial infarction (MI). METHODS:Ad-...

journal_title：European journal of heart failure

authors： Ye L,Haider HKh,Jiang S,Tan RS,Toh WC,Ge R,Sim EK

更新日期：2007-05-01 00:00:00