The incomplete bucindolol evaluation in acute myocardial infarction Trial (BEAT).

Abstract:

UNLABELLED:The aim of this study was to evaluate the efficacy of adding the beta-blocker bucindolol to standard therapy shortly after a myocardial infarction in a high-risk population with reduced left ventricular function. METHODS:The study was planned to include 2000 patients with an enzyme confirmed myocardial infarction and severely reduced left ventricular function determined by echocardiography (corresponding to ejection fraction < or =0.35). The primary endpoint was all cause mortality and the secondary endpoints were time to first event of death, progression of heart failure or reinfarction-and the components. The study was closed early due to discontinuation of development of bucindolol by the manufacturer. Therefore, 170 patients were randomised to receive bucindolol and 173 to receive placebo. RESULTS:There were 27 deaths in the bucindolol group and 30 in the placebo group, hazard ratio of bucindolol 0.88 (95% confidence limits 0.5-1.5; P=0.6). There were 9/4 (bucindolol/placebo, P=0.16) heart failure events and 5/17 (P=0.01) reinfarctions in the bucindolol/placebo groups. CONCLUSION:Due to early closure it is unknown whether bucindolol changes mortality in high-risk post myocardial infarct patients when added to best medical therapy. The frequency of reinfarction was significantly reduced.

journal_name

Eur J Heart Fail

authors

Torp-Pedersen C,Køber L,Ball S,Hall A,Brendorp B,Ottesen M,Berning J,Jensen G,Hampton J,Zilles P,Eberle S,Carlsen J

doi

10.1016/s1388-9842(02)00032-6

keywords:

subject

Has Abstract

pub_date

2002-08-01 00:00:00

pages

495-9

issue

4

eissn

1388-9842

issn

1879-0844

pii

S1388984202000326

journal_volume

4

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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    doi:10.1002/ejhf.201

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    更新日期:2015-01-01 00:00:00

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    doi:10.1002/ejhf.111

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    更新日期:2014-07-01 00:00:00

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    journal_title:European journal of heart failure

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.ejheart.2005.11.007

    authors: Køber L,Swedberg K,McMurray JJ,Pfeffer MA,Velazquez EJ,Diaz R,Maggioni AP,Mareev V,Opolski G,Van de Werf F,Zannad F,Ertl G,Solomon SD,Zelenkofske S,Rouleau JL,Leimberger JD,Califf RM

    更新日期:2006-10-01 00:00:00

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    journal_title:European journal of heart failure

    pub_type: 杂志文章

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    authors: Dickinson BA,Semus HM,Montgomery RL,Stack C,Latimer PA,Lewton SM,Lynch JM,Hullinger TG,Seto AG,van Rooij E

    更新日期:2013-06-01 00:00:00

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    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.1974

    authors: Rosenblum H,Masri A,Narotsky DL,Goldsmith J,Hamid N,Hahn RT,Kodali S,Vahl T,Nazif T,Khalique OK,Bokhari S,Soman P,Cavalcante JL,Maurer MS,Castaño A

    更新日期:2020-07-30 00:00:00

  • Fluid loss, venous congestion, and worsening renal function in acute decompensated heart failure.

    abstract:AIMS:To investigate the relationship between decongestion, central venous pressure, and risk of worsening renal function (WRF) in patients with acute decompensated heart failure (ADHF). METHODS AND RESULTS:We studied 475 patients with ADHF, of whom 238 underwent right heart catheterization. Right atrial pressure (RAP)...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurjhf/hft036

    authors: Aronson D,Abassi Z,Allon E,Burger AJ

    更新日期:2013-06-01 00:00:00

  • Mechanical stretch-induced hypertrophy of neonatal rat ventricular myocytes is mediated by beta(1)-integrin-microtubule signaling pathways.

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    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2005.05.014

    authors: Yutao X,Geru W,Xiaojun B,Tao G,Aiqun M

    更新日期:2006-01-01 00:00:00

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    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2003.10.007

    authors: Matsumori A,Nunokawa Y,Yamaki A,Yamamoto K,Hwang MW,Miyamoto T,Hara M,Nishio R,Kitaura-Inenaga K,Ono K

    更新日期:2004-03-01 00:00:00

  • Left ventricular SERCA2a gene down-regulation does not parallel ANP gene up-regulation during post-MI remodelling in rats.

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    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2004.10.007

    authors: Prunier F,Chen Y,Gellen B,Heimburger M,Choqueux C,Escoubet B,Michel JB,Mercadier JJ

    更新日期:2005-08-01 00:00:00

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    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/ejhf.237

    authors: Haver VG,Mateo Leach I,Kjekshus J,Fox JC,Wedel H,Wikstrand J,de Boer RA,van Gilst WH,McMurray JJ,van Veldhuisen DJ,van der Harst P

    更新日期:2015-03-01 00:00:00

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    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hft034

    authors: Herrmann J,Wohlert C,Saguner AM,Flores A,Nesbitt LL,Chade A,Lerman LO,Lerman A

    更新日期:2013-06-01 00:00:00

  • Changes in connexin 43, metalloproteinase and tissue inhibitor of metalloproteinase during tachycardia-induced cardiomyopathy in dogs.

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    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2006.04.014

    authors: Zhong JQ,Zhang W,Gao H,Li Y,Zhong M,Li D,Zhang C,Zhang Y

    更新日期:2007-01-01 00:00:00

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    abstract:AIMS:Despite improvement in prognosis for ST-elevation myocardial infarction (STEMI) patients, mortality remains high in STEMI patients presenting with cardiogenic shock (CS). Right ventricular (RV) dysfunction is an established independent predictor for adverse prognosis in STEMI patients without CS. The purpose of ou...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfp204

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    更新日期:2010-03-01 00:00:00

  • Prognostic importance of exercise brain natriuretic peptide in asymptomatic degenerative mitral regurgitation.

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    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hfs114

    authors: Magne J,Mahjoub H,Pibarot P,Pirlet C,Pierard LA,Lancellotti P

    更新日期:2012-11-01 00:00:00

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    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurjhf/hfq199

    authors: Koehler F,Winkler S,Schieber M,Sechtem U,Stangl K,Böhm M,Boll H,Kim SS,Koehler K,Lücke S,Honold M,Heinze P,Schweizer T,Braecklein M,Kirwan BA,Gelbrich G,Anker SD,TIM-HF Investigators.

    更新日期:2010-12-01 00:00:00

  • Diagnosis and management of aortic valve stenosis in patients with heart failure.

    abstract::Aortic stenosis (AS) is the most frequent degenerative valvular heart disease in Western countries and its prevalence increases in parallel with the ageing process of the population. Heart failure (HF), defined by the presence of reduced left ventricular ejection fraction, may be present in up to a quarter of patients...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1002/ejhf.466

    authors: Kamperidis V,Delgado V,van Mieghem NM,Kappetein AP,Leon MB,Bax JJ

    更新日期:2016-05-01 00:00:00

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    abstract:AIMS:Loop diuretics are essential for the treatment of chronic heart failure (CHF) but short-acting diuretics are reported to induce sympathetic nervous system (SNS) activation. This study was performed to compare therapeutic effects of two loop diuretics, long-acting azosemide and short-acting furosemide, using (123)I...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurjhf/hfr054

    authors: Hisatake S,Nanjo S,Fujimoto S,Yamashina S,Yuzawa H,Namiki A,Nakano H,Yamazaki J

    更新日期:2011-08-01 00:00:00

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    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurjhf/hft113

    authors: Payvar S,Spertus JA,Miller AB,Casscells SW,Pang PS,Zannad F,Swedberg K,Maggioni AP,Reid KJ,Gheorghiade M,Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study with Tolvaptan (EVEREST) Investigators.

    更新日期:2013-12-01 00:00:00

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    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1093/eurjhf/hft075

    authors: Motiwala SR,Szymonifka J,Belcher A,Weiner RB,Baggish AL,Sluss P,Gaggin HK,Bhardwaj A,Januzzi JL

    更新日期:2013-10-01 00:00:00

  • The prognostic significance of heart failure with preserved left ventricular ejection fraction: a literature-based meta-analysis.

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    journal_title:European journal of heart failure

    pub_type: 杂志文章,meta分析

    doi:10.1093/eurjhf/hfp103

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    更新日期:2009-09-01 00:00:00

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    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/eurjhf/hfr139

    authors: Mudge AM,Denaro CP,Scott AC,Atherton JJ,Meyers DE,Marwick TH,Adsett JA,Mullins RW,Suna JM,Scuffham PA,O'Rourke PK

    更新日期:2011-12-01 00:00:00

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    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2008.09.009

    authors: Rossi JS,Flaherty JD,Fonarow GC,Nunez E,Gattis Stough W,Abraham WT,Albert NM,Greenberg BH,O'Connor CM,Yancy CW,Young JB,Davidson CJ,Gheorghiade M

    更新日期:2008-12-01 00:00:00

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    journal_title:European journal of heart failure

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/eurjhf/hfr147

    authors: Guazzi M,Vicenzi M,Arena R

    更新日期:2012-01-01 00:00:00

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    abstract::The Elecsys NT-proBNP assay is based on two polyclonal antibodies directed at residues 1-21 and 39-50 of the NT-proBNP molecule. Analytical performance was assessed using NCCLS protocol EP-5A using three serum pools in a preliminary study then as part of a multicentre evaluation (16 instruments in 8 hospitals). Using ...

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    pub_type: 杂志文章

    doi:10.1016/j.ejheart.2004.01.011

    authors: Collinson PO,Barnes SC,Gaze DC,Galasko G,Lahiri A,Senior R

    更新日期:2004-03-15 00:00:00

  • Clinical significance of pulse pressure in patients with heart failure with preserved left ventricular ejection fraction.

    abstract:AIMS:Although pulse pressure (PP) is a recognized risk factor for various cardiovascular diseases, its association with cardiovascular outcomes in patients with heart failure with preserved ejection fraction (HFpEF) is uncertain. METHODS AND RESULTS:We enrolled 512 of 951 consecutive HFpEF patients admitted to the Kum...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.559

    authors: Tokitsu T,Yamamoto E,Hirata Y,Kusaka H,Fujisue K,Sueta D,Sugamura K,Sakamoto K,Tsujita K,Kaikita K,Hokimoto S,Sugiyama S,Ogawa H

    更新日期:2016-11-01 00:00:00

  • Does the physical examination still have a role in patients with suspected heart failure?

    abstract:AIMS:The prognostic value of signs of congestion in patients suspected of having chronic heart failure (CHF) is unknown. Our objectives were to define their prevalence and specificity in diagnosing CHF and to determine their prognostic value in patients in a community heart failure clinic. METHODS AND RESULTS:Analysis...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究

    doi:10.1093/eurjhf/hfr128

    authors: Damy T,Kallvikbacka-Bennett A,Zhang J,Goode K,Buga L,Hobkirk J,Yassin A,Dubois-Randé JL,Hittinger L,Cleland JG,Clark AL

    更新日期:2011-12-01 00:00:00

  • Outcomes in patients hospitalized for heart failure and chronic obstructive pulmonary disease: differences in clinical profile and treatment between 2002 and 2009.

    abstract:AIMS:Heart failure (HF) and chronic obstructive pulmonary disease (COPD) frequently co-exist, and each is a major public health issue. In a large cohort of hospitalized HF patients, we evaluated: (i) the impact of COPD on clinical outcomes; (ii) whether outcomes and treatments changed from 2002 to 2009; and (iii) the r...

    journal_title:European journal of heart failure

    pub_type: 杂志文章

    doi:10.1002/ejhf.519

    authors: Staszewsky L,Cortesi L,Tettamanti M,Dal Bo GA,Fortino I,Bortolotti A,Merlino L,Latini R,Roncaglioni MC,Baviera M

    更新日期:2016-07-01 00:00:00

  • Are the effects of drugs to prevent and to treat heart failure always concordant? The statin paradox and its implications for understanding the actions of antidiabetic medications.

    abstract::Most treatments for chronic heart failure are effective both in preventing its onset and reducing its progression. However, statins prevent the development of heart failure, but they do not decrease morbidity and mortality in those with established heart failure. This apparent discordance cannot be explained by an eff...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,评审

    doi:10.1002/ejhf.1183

    authors: Packer M

    更新日期:2018-07-01 00:00:00

  • Efficacy of a homeopathic Crataegus preparation compared with usual therapy for mild (NYHA II) cardiac insufficiency: results of an observational cohort study.

    abstract:OBJECTIVES:To compare the efficacy of the homeopathic Crataegus preparation Cralonin for non-inferiority to standard treatment for mild cardiac insufficiency. METHODS:Multicentre non-randomised cohort study in patients aged 50-75 years in New York Heart Association class II. Patients received Cralonin (n=110) or ACE i...

    journal_title:European journal of heart failure

    pub_type: 杂志文章,多中心研究

    doi:10.1016/s1388-9842(02)00237-4

    authors: Schröder D,Weiser M,Klein P

    更新日期:2003-06-01 00:00:00