Abstract:
AIMS:It is unclear whether myocardial velocity or deformation indices of dyssynchrony are better at predicting response to cardiac resynchronization therapy (CRT). Therefore, two indices of left ventricular (LV) dyssynchrony based on myocardial velocity and deformation were compared to predict success of CRT. METHODS AND RESULTS:Sixty patients with dilated cardiomyopathy, New York Heart Association class III-IV, LV ejection fraction (EF) < or =35%, QRS >120 ms underwent CRT. The standard deviation of the averaged time-to-peak longitudinal negative strain (Tepsilon-SD) and positive systolic velocity (Tv-SD) of 12 LV segments were calculated before and after 6 months of CRT. Responders were defined at month 6 by > or =20% EF increase and/or > or =15% end-systolic volume (ESV) decrease with respect to baseline. On univariable analysis, baseline Tepsilon-SD and Tv-SD were both significantly associated with CRT response; however, the area under the receiver operating characteristic curve was better for Tepsilon-SD. On bivariable analysis, only Tepsilon-SD retained an independent prognostic value for CRT response. Results of the analysis did not change when the logistic models were adjusted for aetiology. CONCLUSION:Baseline dyssynchrony of longitudinal myocardial peak deformation (Tepsilon-SD) appears to be better than dyssynchrony of longitudinal myocardial peak systolic velocities (Tv-SD) for the identification of CRT responders.
journal_name
Eur J Heart Failjournal_title
European journal of heart failureauthors
Mele D,Toselli T,Capasso F,Stabile G,Piacenti M,Piepoli M,Giatti S,Klersy C,Sallusti L,Ferrari Rdoi
10.1093/eurjhf/hfp032subject
Has Abstractpub_date
2009-04-01 00:00:00pages
391-9issue
4eissn
1388-9842issn
1879-0844pii
hfp032journal_volume
11pub_type
杂志文章,多中心研究abstract:BACKGROUND:Platelet-endothelial interactions modulated by adhesion molecules, may play an important role in the pathogenesis of congestive heart failure (CHF). Soluble levels of these molecules and platelet-derived substances are reportedly elevated in patients with CHF. However, no data are available on the plasma lev...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/s1388-9842(99)00029-x
更新日期:1999-08-01 00:00:00
abstract:AIMS:To assess cardiac gene expression in peripheral blood cells of patients with idiopathic dilated cardiomyopathy (IDCM) and its relationship to echocardiographic left ventricular (LV) function. METHODS AND RESULTS:A complete echocardiographic study and blood sampling were performed in 65 consecutive stable IDCM pat...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1093/eurjhf/hfq057
更新日期:2010-06-01 00:00:00
abstract::Heart rate not only predicts outcome but may also be a therapeutic target in patients with chronic heart failure. Several classes of pharmacological agents can be used to modulate heart rate, including beta-blockers, ivabradine, digoxin, amiodarone, and verapamil. Choice of agent will depend on heart rhythm, co-morbid...
journal_title:European journal of heart failure
pub_type: 杂志文章,评审
doi:10.1093/eurjhf/hft129
更新日期:2014-01-01 00:00:00
abstract::Aortic stenosis (AS) is the most frequent degenerative valvular heart disease in Western countries and its prevalence increases in parallel with the ageing process of the population. Heart failure (HF), defined by the presence of reduced left ventricular ejection fraction, may be present in up to a quarter of patients...
journal_title:European journal of heart failure
pub_type: 杂志文章,评审
doi:10.1002/ejhf.466
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:The role of the right ventricle has been relatively neglected proportionate to its importance. We sought to evaluate the impact of right ventricular (RV) and NT-proBNP on the outcome of patients with heart failure (HF) and functional mitral regurgitation (MR). METHODS AND PATIENTS:Outpatients with left vent...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2008.04.003
更新日期:2008-06-01 00:00:00
abstract::Patients with obesity, a reduced exercise capacity, increased cardiac filling pressures and a measured left ventricular ejection fraction in the normal range do not have a homogeneous disorder, but instead, exhibit one of three phenotypes. First, many obese people exhibit sodium retention, plasma volume expansion and ...
journal_title:European journal of heart failure
pub_type: 杂志文章,评审
doi:10.1002/ejhf.1377
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Ultrastructural findings of idiopathic dilated cardiomyopathy (IDCM) include myocyte atrophy and myofilament loss, yet little is known about the vascular abnormalities present in IDCM. METHODS AND RESULTS:Patients with IDCM and controls underwent multi-slice CT to examine length and diameter of epicardial v...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2007.07.008
更新日期:2007-10-01 00:00:00
abstract:BACKGROUND:The rate constant for global fatty acid influx (k(1)) was studied in 12 male patients with dilated cardiomyopathy (DCM). METHOD:10 normal subjects served as controls. 201-Thallium (201TI) and [123I]-phenyl-pentadecanoic acid (IPPA) were administered during bicycle exercise under fasting conditions. RESULTS...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/s1388-9842(02)00024-7
更新日期:2002-08-01 00:00:00
abstract::The European Society of Cardiology heart failure guidelines firmly recommend regular physical activity and structured exercise training (ET), but this recommendation is still poorly implemented in daily clinical practice outside specialized centres and in the real world of heart failure clinics. In reality, exercise i...
journal_title:European journal of heart failure
pub_type: 共识发展会议,杂志文章
doi:10.1093/eurjhf/hfr017
更新日期:2011-04-01 00:00:00
abstract:AIMS:Monitoring early signs of clinical deterioration could allow physicians to adjust medical treatment for patients at risk of acute heart failure decompensation. To date, several strategies using different surrogate measures of clinical status emerged, but none has yet been proven to predict clinical events. We hypo...
journal_title:European journal of heart failure
pub_type: 临床试验,杂志文章
doi:10.1002/ejhf.79
更新日期:2014-06-01 00:00:00
abstract:AIMS:Latent heart failure at rest can be observed in a number of patients upon exercise. Considering left atrial (LA) remodelling as the reflection of the cumulative effects of the LV filling pressure (FP) over time, our aim was to investigate whether the LA volume would predict abnormal exercise LVFP. METHODS AND RES...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.131
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:Carvedilol is a beta-blocker with similar affinity for beta1- and beta2 receptors, while bisoprolol has higher beta1 affinity. The respiratory system is characterized by beta2-receptor prevalence. Airway beta receptors regulate bronchial tone and alveolar beta receptors regulate alveolar fluid re-absorption ...
journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ejheart.2007.04.006
更新日期:2007-08-01 00:00:00
abstract::Carvedilol has been shown to be beneficial for patients with heart failure, but it is not clear how it should be initiated in routine clinical practice, particularly in the elderly. This study is a retrospective review of 19 patients of age 80+/-4 years with heart failure, who had Carvedilol treatment initiated in a r...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/s1388-9842(00)00092-1
更新日期:2000-09-01 00:00:00
abstract:AIM:The exercise Doppler echocardiographic stress test can be of interest in the management of asymptomatic patients with primary mitral regurgitation (MR). The resting brain natriuretic peptide (BNP) level is a good surrogate marker of the consequences of MR and is a powerful predictor of outcome. The incremental prog...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1093/eurjhf/hfs114
更新日期:2012-11-01 00:00:00
abstract:AIMS:Supervised exercise can benefit selected patients with heart failure, however the effectiveness of home-based exercise remains uncertain. We aimed to assess the effectiveness of a home-based exercise programme in addition to specialist heart failure nurse care. METHODS AND RESULTS:This was a randomized controlled...
journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
doi:10.1093/eurjhf/hfn029
更新日期:2009-02-01 00:00:00
abstract:AIMS:To evaluate right-ventricular (RV) function during stress echocardiography (SE) and to assess its relationship with exercise capacity in heart failure (HF) patients. METHODS AND RESULTS:We included 88 patients aged 60.9 +/- 11.2 years with a mean LVEF of 27.2 +/- 9.5%. The following RV parameters were measured at...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1093/eurjhf/hfp200
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:The association between serum digoxin concentration (SDC) and outcomes in women with heart failure (HF) has not been well studied. AIMS:To test the hypothesis that the effect of digoxin on outcomes in women with HF is bi-directional and dependent on SDC, as in men, and is modified by ejection fraction (EF)....
journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ejheart.2005.10.002
更新日期:2006-06-01 00:00:00
abstract::Impaired cardiac function is frequently accompanied by peripheral vascular dysfunction and a pro-inflammatory condition, which may be associated with elevated levels of angiotensin II. We hypothesized that the magnitude of flow mediated dilatation (FMD) of the brachial artery of post myocardial infarction patients wil...
journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ejheart.2005.10.011
更新日期:2006-08-01 00:00:00
abstract:AIMS:Brain natriuretic peptide (BNP), NT-proBNP and troponins are useful for the assessment of patients with heart failure. Few data exist about their serial changes and their prognostic value in patients with acute heart failure (AHF). METHODS AND RESULTS:NT-proBNP and troponin-T plasma levels were measured at baseli...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2007.05.007
更新日期:2007-08-01 00:00:00
abstract::The TRUE-AHF is a randomized, double-blind, parallel-group, placebo-controlled trial which is evaluating the effects of a 48-h infusion of ularitide (15 ng/kg/min) on the short- and long-term clinical course of patients with acute heart failure. Noteworthy features of the study include the early enrolment of patients ...
journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究
doi:10.1002/ejhf.698
更新日期:2017-05-01 00:00:00
abstract:AIMS:Impaired tissue perfusion is often observed in patients with acute heart failure. We tested whether low-dose nitroglycerin (NTG) improves microcirculatory perfusion in patients admitted for acute heart failure. METHODS AND RESULTS:In 20 acute heart failure patients, NTG was given as intravenous infusion at a fixe...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1093/eurjhf/hfp021
更新日期:2009-04-01 00:00:00
abstract:BACKGROUND:Chronic heart failure (CHF) is common and is frequently managed by primary care physicians (PCPs). Despite the European Society of Cardiology (ESC) Guidelines, standard treatments for CHF are frequently underutilised, particularly in primary care. AIM:To evaluate current drug therapy for CHF in adults with ...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2004.09.003
更新日期:2004-10-01 00:00:00
abstract:AIMS:We sought to describe the frequency, type and timing of clinical events, and delineate patterns in their transitions, after a first episode of heart failure (HF). METHODS AND RESULTS:In 1036 Framingham participants with new-onset HF (mean age 79 years; 53% women), we used mixture models to estimate probabilities ...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.1918
更新日期:2020-10-01 00:00:00
abstract:AIMS:Heart failure (HF) quality registries report quality of care but it is unknown whether they improve outcomes. The aims were to assess predictors of enrolment in a HF registry, test the hypothesis that enrolment in a HF registry is associated with reduced mortality, and assess potential explanatory factors for this...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.762
更新日期:2017-09-01 00:00:00
abstract:AIMS:Over the last 30 years, many medicine development programmes in acute and chronic heart failure (HF) with preserved ejection fraction (HFpEF) have failed, in contrast to those in HF with reduced ejection fraction (HFrEF). We explore how the neutral results in larger HF trials may be attributable to chance and/or t...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.1780
更新日期:2020-09-01 00:00:00
abstract:AIMS:Transcatheter tricuspid valve repair (TTVR) is an emerging technique to treat tricuspid regurgitation (TR). Predictors of adverse outcomes are scarce, and stratification by TR aetiologies is lacking. METHODS AND RESULTS:We report the bi-centre procedural outcomes of 164 patients undergoing TTVR for TR stratified ...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.1547
更新日期:2019-09-01 00:00:00
abstract:AIMS:The most recent European guidelines have proposed new definitions of pulmonary hypertension (PH) in left heart disease, to better approach the characteristics required to reflect the presence of pulmonary vascular disease. The purpose of this study was to assess whether different haemodynamic definitions of post-c...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.1067
更新日期:2018-04-01 00:00:00
abstract::Nitric oxide (NO) appears to play a role in modulating cardiac function in both health and disease. Early studies in isolated rodent cardiac myocytes demonstrated a depressant effect of NO supplied by NO donors (exogenous) as well as NO generated within myocytes (endogenous). There is increasing evidence for a functio...
journal_title:European journal of heart failure
pub_type: 杂志文章,评审
doi:10.1016/s1388-9842(01)00163-5
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:Cognitive impairment is common among chronic heart failure (CHF) patients. AIMS:To determine the prognostic significance of cognitive impairment in patients participating in a randomized study of a CHF management program (CHF-MP). METHODS:CHF patients were randomized to a CHF-MP (n=100) or usual care (n=10...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2005.11.013
更新日期:2006-08-01 00:00:00
abstract:UNLABELLED:The aim of this study was to evaluate the efficacy of adding the beta-blocker bucindolol to standard therapy shortly after a myocardial infarction in a high-risk population with reduced left ventricular function. METHODS:The study was planned to include 2000 patients with an enzyme confirmed myocardial infa...
journal_title:European journal of heart failure
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s1388-9842(02)00032-6
更新日期:2002-08-01 00:00:00