Abstract:
:Heart rate not only predicts outcome but may also be a therapeutic target in patients with chronic heart failure. Several classes of pharmacological agents can be used to modulate heart rate, including beta-blockers, ivabradine, digoxin, amiodarone, and verapamil. Choice of agent will depend on heart rhythm, co-morbidities, and disease phenotype. Beneficial and harmful interactions may also exist. The aim of this paper is to summarize the current body of knowledge regarding the relevance of heart rate as a prognostic factor (risk marker) and particularly as a therapeutic target (risk factor) in patients with chronic heart failure, with a special focus on ivabradine, a novel agent that is currently the only available purely bradycardic agent.
journal_name
Eur J Heart Failjournal_title
European journal of heart failureauthors
Dobre D,Borer JS,Fox K,Swedberg K,Adams KF,Cleland JG,Cohen-Solal A,Gheorghiade M,Gueyffier F,O'Connor CM,Fiuzat M,Patak A,Piña IL,Rosano G,Sabbah HN,Tavazzi L,Zannad Fdoi
10.1093/eurjhf/hft129subject
Has Abstractpub_date
2014-01-01 00:00:00pages
76-85issue
1eissn
1388-9842issn
1879-0844pii
hft129journal_volume
16pub_type
杂志文章,评审abstract:AIMS:Recent studies have shown that microRNAs (miRNAs), besides being potent regulators of gene expression, can additionally serve as circulating biomarkers of disease. The aim of this study is to determine if plasma miRNAs can be used as indicators of disease progression or therapeutic efficacy in hypertension-induced...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1093/eurjhf/hft018
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Suppression of the renin-angiotensin-aldosterone system (RAAS) is therapeutically valuable in chronic heart failure (CHF). RAAS inhibition can be achieved in a number of ways though an orally active renin inhibitor (RI) has never been studied before. We describe the neurohumoral effects of an RI. METHODS AN...
journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ejheart.2007.09.002
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:To determine the acute vasodilator effect of sublingual sildenafil in heart transplant candidates with severe pulmonary hypertension due to severe left ventricular dysfunction (LVD). BACKGROUND:Pulmonary hypertension confers an increased risk of early graft failure. PATIENTS AND METHODS:Seven patients, (mea...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2003.11.015
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:Heart failure with preserved ejection fraction (HFpEF) is a global public health problem. Unfortunately, little is known about HFpEF across Asia. METHODS AND RESULTS:We prospectively studied clinical characteristics, echocardiographic parameters and outcomes in 1204 patients with HFpEF (left ventricular eje...
journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究
doi:10.1002/ejhf.1227
更新日期:2019-01-01 00:00:00
abstract:AIM:To describe differences in patient characteristics and outcomes by ethnicity in patients with diabetes mellitus (DM) and heart failure (HF) with reduced ejection fraction (HFrEF, ejection fraction ≤35%) in a multi-ethnic cohort. METHODS AND RESULTS:Patient level data from two cohorts (HF-ACTION and ASIAN-HF) were ...
journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/ejhf.1223
更新日期:2018-09-01 00:00:00
abstract:AIMS:The MITRA-FR trial showed that among symptomatic patients with severe secondary mitral regurgitation, percutaneous repair did not reduce the risk of death or hospitalization for heart failure at 12 months compared with guideline-directed medical treatment alone. We report the 24-month outcome from this trial. MET...
journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/ejhf.1616
更新日期:2019-12-01 00:00:00
abstract:AIMS:Heart failure (HF) patients may be at risk of prescription of potentially inappropriate medicines (PIMs) yet no disease-specific list is available to assess PIM use in this population. A Consensus Potentially Inappropriate Medicines in Heart Failure (PIMHF) list was developed, assessed, and compared with an establ...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.132
更新日期:2014-08-01 00:00:00
abstract:AIMS:As pulmonary arterial hypertension (PAH) is associated with significant morbidity and mortality, particularly among patients with right ventricular (RV) dysfunction, we aimed to determine the impact of therapy to reduce pulmonary vascular resistance (PVR) on RV and LV deformation in PAH. METHODS AND RESULTS:Right...
journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
doi:10.1002/ejhf.177
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:We describe the baseline characteristics of subjects randomised in the largest placebo-controlled, morbidity-mortality trial to date in patients with heart failure and preserved ejection fraction - the irbesartan in heart failure with preserved systolic function trial (I-PRESERVE). METHODS AND RESULTS:4133 ...
journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ejheart.2007.12.010
更新日期:2008-02-01 00:00:00
abstract::The incidence and prevalence of cardiovascular disease increases progressively with advancing age. Cardiovascular disease is a major cause of morbidity and mortality in Western Countries. In the near future, as the population ages, it is expected that the population prevalence of cardiovascular disease will increase d...
journal_title:European journal of heart failure
pub_type: 杂志文章,评审
doi:10.1016/j.ejheart.2008.08.007
更新日期:2008-11-01 00:00:00
abstract:AIMS:Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) support stabilizes patients with cardiogenic shock. Despite improved oxygenation and peripheral circulation, LV unloading may be impeded due to the increased afterload, resulting in a failing static left ventricle and in high mortality. METHODS AND RESUL...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.668
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Hereditary hemochromatosis (HH), a common autosomal recessive disease, leads to excessive iron accumulation in some organs, including the heart. It is therefore not surprising that cardiomyopathy is one of the most severe complications of HH. The HFE gene defects have been thought to contribute to idiopathic...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2004.03.007
更新日期:2005-01-01 00:00:00
abstract:AIMS:Myostatin inhibits myoblast differentiation/proliferation and may play a role in heart failure (HF) and reverse remodelling after left ventricular assist device (LVAD) support. This study sought to characterize myostatin expression and activation in advanced HF before and after LVAD support. METHODS AND RESULTS:L...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1093/eurjhf/hfq039
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Nuclear factor kappa B (NF-kappaB) is activated by several factors, which increase the inflammatory response, and this activation, in turn, leads to the expression of several genes such as cytokines, and may play an important role in cardiovascular diseases. AIMS:The aim of the study is to examine the effec...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2003.10.007
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:In patients with heart failure and reduced left ventricular ejection fraction, angiotensin receptor blockers have been found to reduce mortality and morbidity and to prevent or reverse left ventricular remodelling, compared to optimized background treatment. In light of these data, The Heart failure Endpoint...
journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.ejheart.2008.07.004
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Coronary artery disease (CAD) is frequent among patients hospitalized with acute heart failure syndromes (AHFS). AIMS:To describe the influence of coronary revascularization status on survival in patients with AHFS. METHODS AND RESULTS:OPTIMIZE-HF enrolled 48,612 patients with AHFS from 259 U.S. hospitals....
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2008.09.009
更新日期:2008-12-01 00:00:00
abstract:AIMS:To determine whether a strategy of intensive blood pressure control reduces the risk of heart failure (HF) events consistently across the spectrum of kidney function and albuminuria. METHODS AND RESULTS:SPRINT was a randomized clinical trial in which 9361 individuals ≥50 years, at high risk for or with cardiovasc...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.1971
更新日期:2020-07-21 00:00:00
abstract:AIMS:We investigated the association between quantified metabolite, lipid and lipoprotein measures and incident heart failure hospitalisation (HFH) in the elderly, and examined whether circulating metabolic measures improve HFH prediction. METHODS AND RESULTS:Overall, 80 metabolic measures from the PROspective Study o...
journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/ejhf.1076
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:Carvedilol is a beta-blocker with similar affinity for beta1- and beta2 receptors, while bisoprolol has higher beta1 affinity. The respiratory system is characterized by beta2-receptor prevalence. Airway beta receptors regulate bronchial tone and alveolar beta receptors regulate alveolar fluid re-absorption ...
journal_title:European journal of heart failure
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.ejheart.2007.04.006
更新日期:2007-08-01 00:00:00
abstract::The European Society of Cardiology heart failure guidelines firmly recommend regular physical activity and structured exercise training (ET), but this recommendation is still poorly implemented in daily clinical practice outside specialized centres and in the real world of heart failure clinics. In reality, exercise i...
journal_title:European journal of heart failure
pub_type: 共识发展会议,杂志文章
doi:10.1093/eurjhf/hfr017
更新日期:2011-04-01 00:00:00
abstract:AIM:The exercise Doppler echocardiographic stress test can be of interest in the management of asymptomatic patients with primary mitral regurgitation (MR). The resting brain natriuretic peptide (BNP) level is a good surrogate marker of the consequences of MR and is a powerful predictor of outcome. The incremental prog...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1093/eurjhf/hfs114
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Chronic heart failure (CHF) is common and is frequently managed by primary care physicians (PCPs). Despite the European Society of Cardiology (ESC) Guidelines, standard treatments for CHF are frequently underutilised, particularly in primary care. AIM:To evaluate current drug therapy for CHF in adults with ...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2004.09.003
更新日期:2004-10-01 00:00:00
abstract::Many patients with Congestive Heart Failure (CHF) are anaemic. This anaemia is associated with more severe CHF and a higher incidence of mortality, hospitalisation and morbidity. The only way to prove that the anaemia is causing this worsening of CHF is to correct it. We review here some of the published papers about ...
journal_title:European journal of heart failure
pub_type: 杂志文章,评审
doi:10.1016/j.ejheart.2008.06.015
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND:Serial measurements of N-terminal pro brain natriuretic peptide (NT-proBNP) have been suggested for the management of outpatients with chronic heart failure (CHF). The relationship between NT-proBNP plasma levels and central haemodynamic parameters in this setting is not known. METHODS:In 19 outpatients wit...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2006.03.002
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:New-onset atrial fibrillation (AF) after acute myocardial infarction (AMI) frequently occurs in association with postinfarction complications, particularly with heart failure (HF). AIMS:To evaluate whether postinfarction HF is associated with the subsequent development of AF and whether AF independently pre...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/j.ejheart.2004.07.018
更新日期:2005-06-01 00:00:00
abstract:AIMS:Women are more likely to develop heart failure with preserved ejection fraction (HFpEF) than men. We studied the relationship between sex and cardiovascular structure and function in patients with HFpEF. METHODS AND RESULTS:The study included 279 participants from the PARAMOUNT study (57% women) with analysable b...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1002/ejhf.67
更新日期:2014-05-01 00:00:00
abstract::Alternations in gut microbial composition (i.e. loss of microbial diversity or 'gut dysbiosis') have been associated with heart failure with reduced ejection fraction (HFrEF). It has also been suggested that increased chronic low-level inflammation and immune system dysregulation seen in patients with HFrEF could be r...
journal_title:European journal of heart failure
pub_type: 杂志文章,评审
doi:10.1002/ejhf.1792
更新日期:2020-04-01 00:00:00
abstract:AIMS:Structural abnormalities causing cardiac deterioration in hypertensive heart disease (HHD) are poorly understood. The aim of the study was to evaluate left ventricular (LV) myocardial changes in patients with HHD and cardiac failure. METHODS AND RESULTS:Among 1229 patients undergoing an LV or biventricular endomy...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1093/eurjhf/hfs169
更新日期:2013-03-01 00:00:00
abstract:BACKGROUND AND AIMS:The diagnosis of heart failure is an important clinical problem and yet reported diagnostic accuracy in primary care is less than 50%. We established a Rapid Access Heart Failure Clinic (RAHFC) in a district general hospital serving a population of 292,000 in SE London, UK, to diagnose and manage ne...
journal_title:European journal of heart failure
pub_type: 杂志文章
doi:10.1016/s1388-9842(00)00108-2
更新日期:2000-12-01 00:00:00
abstract:AIMS:To test the hypothesis that an earlier post-acute myocardial infarction (AMI) eplerenone initiation in patients with left ventricular systolic dysfunction (LVSD) and heart failure (HF) is associated with better long-term outcomes. METHODS AND RESULTS:The 6632 patients of the EPHESUS study were randomized from day...
journal_title:European journal of heart failure
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1093/eurjhf/hfp136
更新日期:2009-11-01 00:00:00