Biological role of vitamin C in keratinocytes.

Abstract:

:Epidemiological studies have suggested an association between vitamin C (and other antioxidant vitamins) and cancer risk. However, the mechanisms accounting for prevention have not been extensively investigated. In skin, vitamin C (ascorbic acid) exerts different biological roles, including photoprotective effects and participation in collagen synthesis. This paper reports new findings about additional functions of the vitamin. Vitamin C counteracts oxidative stress via transcriptional and post-translational mechanisms; this modulation may interfere with the activity of redox-sensitive transcription factors, commitment to differentiation or cell cycle arrest, and apoptosis in response to DNA damage. All of these vitamin C-mediated responses might be important in different cell types, allowing for the maintenance of body homeostasis.

journal_name

Nutr Rev

journal_title

Nutrition reviews

authors

Catani MV,Savini I,Rossi A,Melino G,Avigliano L

doi

10.1111/j.1753-4887.2005.tb00125.x

keywords:

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

81-90

issue

3

eissn

0029-6643

issn

1753-4887

journal_volume

63

pub_type

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