INDUCTION OF NONSPECIFIC RESISTANCE BY ENDOTOXIN IN UNRESPONSIVE MICE.

Abstract:

:Margherita, S. S. (Temple University School of Medicine, Philadelphia, Pa.), and H. Friedmann. Induction of nonspecific resistance by endotoxin in unresponsive mice. J. Bacteriol. 89:277-280. 1965.-Serratia marcescens endotoxin was tested for protective effect in animals of varying immunological competence. A quantity of endotoxin capable of inducing resistance in mice to a standardized challenge of Diplococcus pneumoniae was equally effective in animals immunologically paralyzed with a high dose of homologous pneumococcal polysaccharide. Failure of the unresponsive state to influence the degree of resistance induced by endotoxin suggests that a specific humoral factor does not play a significant role in the nonspecific resistance.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

MARGHERITA SS,FRIEDMAN H

doi

10.1128/JB.89.2.277-280.1965

keywords:

subject

Has Abstract

pub_date

1965-02-01 00:00:00

pages

277-80

eissn

0021-9193

issn

1098-5530

journal_volume

89

pub_type

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