Induction of experimental chronic arthritis in rabbits by cell-free fragments of Erysipelothrix.

Abstract:

:A cell-free crude extract of Erysipelothrix rhusiopathiae injected by high pressure jet into the knee-joint of rabbits stimulated an acute, mild inflammatory reaction. Additional injections at 3-day intervals induced a chronic condition characterized by hyperplasia of the synovial cells and hypertrophy of the villi, due to infiltration by lymphocytes and plasma cells which formed aggregates resembling Allison-Ghormley bodies. There was also extensive proliferation of stroma vasculature and fibrous tissue. A similar jet injection of the diluent produced an early, transient, acute, and mild inflammation. A mechanism is postulated for fixation of one or more of the chemically characterized antigens in or near the synovium as a means of inducing the localized inflammatory response that predisposes the joint to infection.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

White TG,Puls JL

doi

10.1128/JB.98.2.403-406.1969

subject

Has Abstract

pub_date

1969-05-01 00:00:00

pages

403-6

issue

2

eissn

0021-9193

issn

1098-5530

journal_volume

98

pub_type

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