Characterization of a bovine synovial fluid lubricating factor. III. The interaction with hyaluronic acid.

Abstract:

:Although hyaluronate is not a boundary lubricant in cartilaginous and latex:glass bearings, a distinct interaction with purified synovial lubricating factor (PSLF) was demonstrated by three means: 1) enhancement of lubricating ability in an artificial test system; 2) viscometry; 3) electron microscopy. The interaction was of a physical rather than a specific chemical type; it varied with the degree of purification of PSLF and of hyaluronate. The interaction accounts for retention of the relatively small PSLF molecule (approximately 280 kDa) with the synovial mucin on a 0.22 microns filter. The data provide evidence that hyaluronate and PSLF act synergistically in the boundary lubricating activity of animal joints.

journal_name

Connect Tissue Res

authors

Jay GD,Lane BP,Sokoloff L

doi

10.3109/03008209209016818

keywords:

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

245-55

issue

4

eissn

0300-8207

issn

1607-8438

journal_volume

28

pub_type

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