Abstract:
:Synthetic glucocorticoids are potent modulators of the immune system, and are clinically invaluable in the treatment of a wide variety of conditions. However, their use can be limited by harmful side effects, and their mechanisms of action remain poorly understood and controversial. It has recently been reported that glucocorticoids induce the expression of two genes that participate in cross-talk with the mitogen-activated protein kinase signalling pathways. It is possible that both therapeutic and harmful effects of glucocorticoids may be mediated by these genes.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Clark AR,Lasa Mdoi
10.1016/s1471-4892(03)00073-0keywords:
subject
Has Abstractpub_date
2003-08-01 00:00:00pages
404-11issue
4eissn
1471-4892issn
1471-4973pii
S1471489203000730journal_volume
3pub_type
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