Crosstalk between glucocorticoids and mitogen-activated protein kinase signalling pathways.

Abstract:

:Synthetic glucocorticoids are potent modulators of the immune system, and are clinically invaluable in the treatment of a wide variety of conditions. However, their use can be limited by harmful side effects, and their mechanisms of action remain poorly understood and controversial. It has recently been reported that glucocorticoids induce the expression of two genes that participate in cross-talk with the mitogen-activated protein kinase signalling pathways. It is possible that both therapeutic and harmful effects of glucocorticoids may be mediated by these genes.

journal_name

Curr Opin Pharmacol

authors

Clark AR,Lasa M

doi

10.1016/s1471-4892(03)00073-0

keywords:

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

404-11

issue

4

eissn

1471-4892

issn

1471-4973

pii

S1471489203000730

journal_volume

3

pub_type

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