Abstract：
:Angiotensin II blockade has become a standard anti-fibrotic therapy in renal diseases because it slows progression to end-stage renal disease. However, current data support the notion that angiotensin II blockade alone cannot stop progressive fibrotic disease. Of an increasing number of therapies showing efficacy in animal studies, antibodies to transforming growth factor beta are the most thoroughly studied and are likely to be effective in human clinical trials. However, hints exist in the literature suggesting that no single agent will effectively halt renal fibrosis and that combinations of agents will be required.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Yu L,Noble NA,Border WAdoi
10.1016/s1471-4892(02)00144-3keywords:
subject
Has Abstractpub_date
2002-04-01 00:00:00pages
177-81issue
2eissn
1471-4892issn
1471-4973pii
S1471489202001443journal_volume
2pub_type
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