Strontium as therapy for osteoporosis.

abstract：:Biomedical applications of porous silicon include drug delivery, imaging, diagnostics and immunotherapy. This review summarizes new silicon particle fabrication techniques, dynamics of cellular transport, advances in the multistage vector approach to drug delivery, and the use of porous silicon as immune adjuvants. Re...

journal_title：Current opinion in pharmacology

authors： Savage DJ,Liu X,Curley SA,Ferrari M,Serda RE

更新日期：2013-10-01 00:00:00

abstract：:Tuberculosis now ranks as the leading cause of death in the world due to a single infectious agent. Current standard of care treatment can achieve very high cure rates for drug-sensitive disease but requires a 6-month duration of chemotherapy. Drug-resistant disease requires significantly longer treatment durations wi...

journal_title：Current opinion in pharmacology

authors： J Libardo MD,Boshoff HI,Barry CE 3rd

更新日期：2018-10-01 00:00:00

abstract：:Light offers unique advantages for studying and manipulating biomolecules and the cellular processes that they control. Optical control of ionotropic and metabotropic glutamate receptors has garnered significant interest, since these receptors are central to signaling at neuronal synapses and only optical approaches p...

journal_title：Current opinion in pharmacology

authors： Reiner A,Levitz J,Isacoff EY

更新日期：2015-02-01 00:00:00

abstract：:Prostate cancer risk can be modified by environmental factors, however the molecular mechanisms affecting susceptibility to this disease are not well understood. As a result of a series of recently published studies, the steroidal lipid, cholesterol, has emerged as a clinically relevant therapeutic target in prostate ...

journal_title：Current opinion in pharmacology

authors： Pelton K,Freeman MR,Solomon KR

更新日期：2012-12-01 00:00:00

abstract：:COPD is a disease manifested as persistent airflow obstruction with an enhanced inflammatory response in the airways and lungs to noxious particles and gases which evokes symptoms of dyspnea on exertion, cough and mucus production. Airway smooth muscle plays a central role in the COPD diathesis and is implicated in ma...

journal_title：Current opinion in pharmacology

authors： Banerjee A,Panettieri R Jr

更新日期：2012-06-01 00:00:00

abstract：:Clostridium difficile disease is the major, known cause of nosocomial diarrhea and is an emerging cause of community-associated diarrhea. Recent outbreaks due to a strain of apparent increased virulence, BI/NAP1, and recognition of increasing metronidazole treatment failures as well as the morbidity associated with re...

journal_title：Current opinion in pharmacology

authors： Balagopal A,Sears CL

更新日期：2007-10-01 00:00:00

abstract：:There have been significant developments in Ebola virus therapeutics. While the efficacy of several products was evaluated in the recent West Africa outbreak, a licensed treatment for EBOV disease remains elusive. Factors that negatively impacted the execution of clinical trials included an overall lack of world readi...

journal_title：Current opinion in pharmacology

authors： Cardile AP,Downey LG,Wiseman PD,Warren TK,Bavari S

更新日期：2016-10-01 00:00:00

abstract：:Most of the G-protein-coupled receptors (GPCRs) in the human genome have been described. Investigation will now shift from discovery to analysis. Like many other genes, those encoding GPCRs are frequently found adjacent to each other in clusters. Duplicated genes often share ligands, signalling pathways and amino acid...

journal_title：Current opinion in pharmacology

authors： Foord SM

更新日期：2002-10-01 00:00:00

abstract：:Fibrosis can occur in most organs and is characterised by excessive and progressive extracellular matrix deposition and destruction of normal tissue architecture and function. In many cases treatment options are limited. Fibrotic diseases are therefore associated with high morbidity and mortality. Tissue biopsies rema...

journal_title：Current opinion in pharmacology

authors： Tatler AL

更新日期：2019-12-01 00:00:00

abstract：:Clinical trials of selective small-molecule inhibitors of epidermal growth factor receptor tyrosine kinase activity have shown that these targeted inhibitors of proliferative signal transduction provide well-tolerated antitumour activity in patients. Preclinical pharmacology studies illustrate the potential use of the...

journal_title：Current opinion in pharmacology

authors： Wakeling AE

更新日期：2002-08-01 00:00:00

abstract：:Metabotropic glutamate receptors (mGluRs) are heavily expressed throughout the basal ganglia (BG), where they modulate neuronal excitability, transmitter release and long term synaptic plasticity. Therefore, targeting specific mGluR subtypes by means of selective drugs could be a possible strategy for restoring normal...

journal_title：Current opinion in pharmacology

authors： Masilamoni GJ,Smith Y

更新日期：2018-02-01 00:00:00

abstract：:The bioavailability of drugs with an absorption window in the upper small intestine is generally limited with conventional pharmaceutical dosage forms. The residence time of such systems and, thus, of their drug release into the stomach and upper intestine is often short. To overcome this restriction and to increase t...

journal_title：Current opinion in pharmacology

authors： Streubel A,Siepmann J,Bodmeier R

更新日期：2006-10-01 00:00:00

abstract：:It has been a few decades since Ca(2+) was identified as one of the important factors that can accelerate gastric wound repair as well as contribute to epithelial homeostasis and regulation of gastric secretions. The mechanistic basis has remained largely unexplored in vivo because it was not possible to track in real...

journal_title：Current opinion in pharmacology

authors： Aihara E,Montrose MH

更新日期：2014-12-01 00:00:00

abstract：:Tissue factor (TF) is the essential cofactor for the coagulation protease factor VIIa (FVIIa), initiating the coagulation cascade. The role of TF in thrombotic diseases is becoming increasingly evident. Recent findings suggest that inhibition of TF/FVIIa activity could be important in the prevention of clinical sequel...

journal_title：Current opinion in pharmacology

authors： Girard TJ,Nicholson NS

更新日期：2001-04-01 00:00:00

abstract：:Immunotherapies revolutionised the treatment of several disorders but show specific side-effect profiles which frequently involve psychological symptoms. Long term interferon-alpha (IFN-alpha) therapy can cause wide-ranging psychiatric side-effects from fatigue, insomnia, anxiety to full-blown depression. This treatme...

journal_title：Current opinion in pharmacology

authors： Kovacs D,Kovacs P,Eszlari N,Gonda X,Juhasz G

更新日期：2016-08-01 00:00:00

abstract：:After a decade of intense pharmacological and drug development activity by the pharmaceutical industry, compounds derived from two key strategies for reducing gastrointestinal effects of non-steroidal anti-inflammatory drugs (NSAIDs) have been subjected to rigorous clinical appraisal. Despite the undoubted therapeutic...

journal_title：Current opinion in pharmacology

authors： Whittle BJ

更新日期：2004-12-01 00:00:00

abstract：:Over the past years tremendous amounts of clinical and fundamental data have been generated about GLP-1 and related therapeutic strategies for the treatment of type 2 diabetes. However, the cellular and physiological mechanisms through which GLP-1 is secreted, controls glycemia, and behaves as a therapeutic agent are ...

journal_title：Current opinion in pharmacology

authors： Burcelin R,Serino M,Cabou C

更新日期：2009-12-01 00:00:00

abstract：:Calcitonin gene related peptide (CGRP) has been proposed to contribute to pain transmission and inflammation and for these reasons to the mechanism of migraine. CGRP is, in fact, expressed in and released from a subset of polymodal primary sensory neurons of the trigeminal ganglion. Release of CGRP in the dorsal spina...

journal_title：Current opinion in pharmacology

authors： Benemei S,Nicoletti P,Capone JG,Geppetti P

更新日期：2009-02-01 00:00:00

abstract：:Cancer vaccines based on synthetic peptides are a safe, well-tolerated immunotherapy able to specifically stimulate tumor-reactive T cells. However, their clinical efficacy does not approach that achieved with other immunotherapies such as immune checkpoint blockade. Nevertheless, major advances have been made in sele...

journal_title：Current opinion in pharmacology

authors： Calvo Tardón M,Allard M,Dutoit V,Dietrich PY,Walker PR

更新日期：2019-08-01 00:00:00

abstract：:Cholesterol epoxide hydrolase (ChEH) catalyzes the hydration of cholesterol-5,6-epoxides (5,6-EC) into cholestane-3β,5α,6β-triol. ChEH is a hetero-oligomeric complex called the anti-estrogen binding site (AEBS) comprising 3β-hydroxysterol-Δ(8)-Δ(7)-isomerase (D8D7I) and 3β-hydroxysterol-Δ(7)-reductase (DHCR7). D8D7I a...

journal_title：Current opinion in pharmacology

authors： Silvente-Poirot S,Poirot M

更新日期：2012-12-01 00:00:00

abstract：:Hypothalamic gonadotropin-releasing hormone (GnRH) is a decapeptide that stimulates pituitary synthesis and secretion of gonadotropins and, therefore, gonadal hormones. GnRH antagonists, of which thousands have been formulated, inhibit the hormone from binding to its receptor, inducing a pharmacological hypophysectomy...

journal_title：Current opinion in pharmacology

authors： Herbst KL

更新日期：2003-12-01 00:00:00

abstract：:Angiotensin type 1 (AT1) receptors are key effector elements of the renin-angiotensin system, mediating virtually all of the classical physiological actions of angiotensin II. Pharmacological blockade of the AT1 receptor effectively lowers blood pressure in a substantial proportion of patients with hypertension, indic...

journal_title：Current opinion in pharmacology

authors： Chen D,Coffman TM

更新日期：2015-04-01 00:00:00

abstract：:Orthostatic hypotension (OH) is a fall in blood pressure after assuming an upright position. Whereas asymptomatic patients usually need no treatment, the majority of symptomatic patients can be cured by avoidance of trigger mechanisms and the use of physical countermaneuvers and non-pharmacological interventions. Seve...

journal_title：Current opinion in pharmacology

authors： Oldenburg O,Kribben A,Baumgart D,Philipp T,Erbel R,Cohen MV

更新日期：2002-12-01 00:00:00

abstract：:White adipose tissue (WAT) is a highly dynamic organ that can vary considerably in mass depending on energy balance. Data from recent cross-sectional and prospective clinical studies have revealed a set of mechanisms that link WAT dysfunction to type 2 diabetes. This review focuses on three of the most important patho...

journal_title：Current opinion in pharmacology

authors： Mejhert N,Rydén M

更新日期：2020-12-01 00:00:00

abstract：:Since its discovery in 1993 and subsequent development of selective antagonists, a growing number of studies support the use of serotonin 5-HT(6) receptor antagonism as a promising mechanism for treating cognitive dysfunction. Lately, several studies with structurally different compounds have shown that not only antag...

journal_title：Current opinion in pharmacology

authors： Codony X,Vela JM,Ramírez MJ

更新日期：2011-02-01 00:00:00

abstract：:High occurrence of penicillin-resistant and multidrug-resistant Streptococcus pneumoniae and reports of resistance with Haemophilus influenzae and Moraxella catarrhalis are influencing the empiric treatment of community-acquired respiratory infections and allowing the new fluoroquinolones to serve as important treatme...

journal_title：Current opinion in pharmacology

authors： Zhanel GG,Noreddin AM

更新日期：2001-10-01 00:00:00

abstract：:Platelets are known to play a pivotal role not only in the formation of arterial thrombosis but also in the progression of atherosclerotic disease. Recent data suggest that these activities of platelets have become enhanced in patients with type 2 diabetes, accounting for many of the cardiovascular complications. Alth...

journal_title：Current opinion in pharmacology

authors： Yan Y,Phillips DR

更新日期：2005-04-01 00:00:00

abstract：:Gasotransmitters fulfill important roles in cellular homeostasis having been linked to various pathologies, including inflammation and cardiovascular diseases. In addition to the known pathways mediating the actions of gasotransmitters, their effects in regulating mitochondrial function are emerging. Given that mitoch...

journal_title：Current opinion in pharmacology

authors： Hendriks KD,Maassen H,van Dijk PR,Henning RH,van Goor H,Hillebrands JL

更新日期：2019-04-01 00:00:00

abstract：:Antidepressants are among the most widely prescribed drugs, however the mechanism underlying their therapeutic efficacy is not known. Neurotrophic factors represent a promising class of targets for antidepressant treatments. We recently characterized a role for vascular endothelial growth factor (VEGF) in cellular and...

journal_title：Current opinion in pharmacology

authors： Warner-Schmidt JL,Duman RS

更新日期：2008-02-01 00:00:00

abstract：:The classical neurotransmitter, serotonin (5-HT), plays an important role outside of the central nervous system in immune signaling. Here I review recent studies describing 5-HT uptake in dendritic cells and B lymphocytes, 5-HT synthesis in T lymphocytes, and the role of specific 5-HT receptor subtypes in innate and a...

journal_title：Current opinion in pharmacology

authors： Ahern GP

更新日期：2011-02-01 00:00:00