Abstract:
:The classical neurotransmitter, serotonin (5-HT), plays an important role outside of the central nervous system in immune signaling. Here I review recent studies describing 5-HT uptake in dendritic cells and B lymphocytes, 5-HT synthesis in T lymphocytes, and the role of specific 5-HT receptor subtypes in innate and adaptive immune cells. Furthermore, a recent paper describing the immune phenotype of 5-HT deficient mice is discussed.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Ahern GPdoi
10.1016/j.coph.2011.02.004subject
Has Abstractpub_date
2011-02-01 00:00:00pages
29-33issue
1eissn
1471-4892issn
1471-4973pii
S1471-4892(11)00017-8journal_volume
11pub_type
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.coph.2005.01.001
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.coph.2007.12.008
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
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journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.coph.2011.02.005
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journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.coph.2008.03.002
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journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
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abstract::In the current of era of developing antibacterial agents, including those for unmet medical need, Sponsors are required to submit a robust pre-clinical pharmacokinetic-pharmacodynamic (PK-PD) data package in exchange for limited clinical data. However, the clinical data package also needs to be as robust as possible. ...
journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
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