abstract：:Nanotechnology in medicine-nanomedicine-is extensively employed to diagnose, treat, and prevent pulmonary diseases. Over the last few years, this brave new world has made remarkable progress, offering opportunities to address historical clinical challenges in pulmonary diseases including multidrug resistance, adverse ...

journal_title：Current opinion in pharmacology

authors： Doroudian M,O' Neill A,Mac Loughlin R,Prina-Mello A,Volkov Y,Donnelly SC

更新日期：2020-12-17 00:00:00

abstract：:Circadian rhythms impact cardiac and vascular pathophysiology, resulting in 24-hour patterning of symptoms and life-threatening/ending events (chronopathology), plus kinetics and dynamics of medications (chronopharmacology), resulting in administration-time differences in efficacy and safety. Scheduling medications ac...

journal_title：Current opinion in pharmacology

authors： Smolensky MH,Hermida RC,Geng YJ

更新日期：2020-12-03 00:00:00

abstract：PURPOSE OF THE REVIEW:Faecal microbiota transplantation (FMT) has emerged as a potent form of therapeutic microbial manipulation. There is much interest in exploring its potential in conditions such as inflammatory bowel disease (IBD) where disturbances in the gastrointestinal microbiota play a crucial role in disease ...

journal_title：Current opinion in pharmacology

authors： Haifer C,Leong RW,Paramsothy S

更新日期：2020-12-01 00:00:00

abstract：:Treatment strategies for inflammatory bowel disease (IBD) now increasingly target deep remission, yet the resultant more aggressive use of medical therapy is associated with potentially serious adverse events and significant costs. It is, therefore, of vital importance to consider when, how and in whom medical therapy...

journal_title：Current opinion in pharmacology

authors： Frias Gomes C,Chapman TP,Satsangi J

更新日期：2020-12-01 00:00:00

abstract：:Therapeutic drug monitoring (TDM) plays a vital role in implementing precision medicine in inflammatory bowel disease (IBD), and may contribute to increased effectiveness, lower rates of drug toxicity and cost savings. While expert panels advocate the use of reactive TDM for anti-tumor necrosis factor (anti-TNF) agent...

journal_title：Current opinion in pharmacology

authors： Alsoud D,Vermeire S,Verstockt B

更新日期：2020-12-01 00:00:00

abstract：:Diabetes diagnosed in adults is a highly heterogeneous disorder. It mostly consists of what is referred to as type 2 diabetes but also comprises other entities (i.e. different diseases), including latent autoimmune diabetes, late onset forms of monogenic diabetes and familial diabetes of the adulthood, which has recen...

journal_title：Current opinion in pharmacology

authors： Trischitta V,Prudente S,Doria A

更新日期：2020-12-01 00:00:00

abstract：:White adipose tissue (WAT) is a highly dynamic organ that can vary considerably in mass depending on energy balance. Data from recent cross-sectional and prospective clinical studies have revealed a set of mechanisms that link WAT dysfunction to type 2 diabetes. This review focuses on three of the most important patho...

journal_title：Current opinion in pharmacology

authors： Mejhert N,Rydén M

更新日期：2020-12-01 00:00:00

abstract：:The non-nucleoside reverse transcriptase inhibitors (NNRTIs) are allosteric inhibitors of HIV-1 reverse transcriptase and are classified into generations depending on their discovery and resistance profiles. The NNRTIs are used in combination regimens with antiretroviral agents that target two or more enzymes in the v...

journal_title：Current opinion in pharmacology

authors： Vanangamudi M,Kurup S,Namasivayam V

更新日期：2020-10-01 00:00:00

abstract：:Heart failure is a leading cause of death in the United States. Diabetes, also known as diabetes mellitus (DM), exponentially increases the risk of heart failure. The increase in oxidative stress and metabolic dysfunction caused by DM can lead to DNA damage and the development of diabetic cardiomyopathy. Ataxia telang...

journal_title：Current opinion in pharmacology

authors： Wingard MC,Frasier CR,Singh M,Singh K

更新日期：2020-10-01 00:00:00

abstract：:Where we are on the road to 'tailor-made' precision medicine for drug-resistant cervical carcinoma? We explored studies about analyses of viral and human genomes, epigenomes and transcriptomes, DNA mutation analyses, their importance in detecting HPV sequences, mechanisms of drug resistance to established and targeted...

journal_title：Current opinion in pharmacology

authors： Diefenbach D,Greten HJ,Efferth T

更新日期：2020-10-01 00:00:00

abstract：:Chronic liver diseases with different etiologies represent a major public health issue worldwide. Liver fibrosis is the common feature of almost all chronic liver diseases and remains a key determinant of clinical prognosis. Over the last two decades, basic science studies have uncovered molecular mechanisms underlyin...

journal_title：Current opinion in pharmacology

authors： Lemoinne S,Friedman SL

更新日期：2019-12-01 00:00:00

abstract：:Fibrosis can occur in most organs and is characterised by excessive and progressive extracellular matrix deposition and destruction of normal tissue architecture and function. In many cases treatment options are limited. Fibrotic diseases are therefore associated with high morbidity and mortality. Tissue biopsies rema...

journal_title：Current opinion in pharmacology

authors： Tatler AL

更新日期：2019-12-01 00:00:00

abstract：:Gut microbiota has a crucial role in the maintenance of health. Increasing evidence suggests that changes or disturbances in gut microbiota may be associated with various diseases. Therefore, preclinical and clinical studies related to gut microbiota are becoming increasingly important. Germ-free animal experimentatio...

journal_title：Current opinion in pharmacology

authors： Uzbay T

更新日期：2019-12-01 00:00:00

abstract：:Human pluripotent stem cells can be differentiated into specific, relevant cell types of interest including the cells of the retina and optic nerve. These cells can then be used to study fundamental biology as well as disease modelling and subsequent screening of potential treatments. Many models of differentiation an...

journal_title：Current opinion in pharmacology

authors： Lidgerwood GE,Hewitt AW,Pébay A

更新日期：2019-10-01 00:00:00

abstract：:New anti-infective drugs are an unmet necessity of modern medicine. The use of ∼omics technologies has exponentially increased the knowledge on active anti-infective structures, where to search for them and their mechanisms of action. Research involving extreme and unique environments (such as endophytes) revealed the...

journal_title：Current opinion in pharmacology

authors： Maldonado-Carmona N,Vázquez-Hernández M,Patiño Chávez OJ,Rodríguez-Luna SD,Jiménez Rodríguez O,Sanchez S,Ceapă CD

更新日期：2019-10-01 00:00:00

abstract：:Antimicrobial resistance is a global threat to the management of infections in our patients. Sound stewardship of antibacterial agents at our disposal must be accompanied by a concerted effort to develop new agents to bolster our armamentarium. This review will cover the latest antibiotics that have come through the p...

journal_title：Current opinion in pharmacology

authors： Gould IM,Gunasekera C,Khan A

更新日期：2019-10-01 00:00:00

abstract：:Cancer vaccines based on synthetic peptides are a safe, well-tolerated immunotherapy able to specifically stimulate tumor-reactive T cells. However, their clinical efficacy does not approach that achieved with other immunotherapies such as immune checkpoint blockade. Nevertheless, major advances have been made in sele...

journal_title：Current opinion in pharmacology

authors： Calvo Tardón M,Allard M,Dutoit V,Dietrich PY,Walker PR

更新日期：2019-08-01 00:00:00

abstract：:Cancer is one of the major growing public health problems making the development of new anti-cancer treatment strategies still compulsory. Conventionally used chemotherapies are quite often associated with severe side effects. One reason is limited cell-permeability of the used drugs resulting in only poor overall bio...

journal_title：Current opinion in pharmacology

authors： Klimpel A,Lützenburg T,Neundorf I

更新日期：2019-08-01 00:00:00

abstract：:Sepsis is life-threatening systemic organ dysfunction caused by a deregulated host response to an infectious insult. Currently, the treatment of sepsis is limited to the use of antibiotics, fluids, and cardiovascular/respiratory support. Despite these interventions, septic mortality remains high, with reduced life qua...

journal_title：Current opinion in pharmacology

authors： Antonioli L,Blandizzi C,Fornai M,Pacher P,Lee HT,Haskó G

更新日期：2019-08-01 00:00:00

abstract：:The inflammatory response is regulated by the production of different extracellular mediators, including lipids and extracellular nucleotides. In the extracellular environment, intermediate lipids activate specific G-protein-coupled receptors (GPCRs) in target cells and promote cell recruitment and activation. Extrace...

journal_title：Current opinion in pharmacology

authors： Alarcón-Vila C,Pizzuto M,Pelegrín P

更新日期：2019-08-01 00:00:00

abstract：:Neuropathic pain is the most important type of chronic pain because it is refractory to available medications. Neuropathic pain occurs after peripheral nerve injury (PNI) or nerve damage by various reasons. In recent decades, a growing body of evidence shows that spinal microglia and P2X4 receptor (P2X4R), a subtype o...

journal_title：Current opinion in pharmacology

authors： Inoue K

更新日期：2019-08-01 00:00:00

abstract：:Rosacea is a common inflammatory skin disease that is difficult to manage because of the unknown etiology and due to its variable manifestations. These facts and the few new available treatment options make it difficult to select a really effective treatment. This review aims to assess the efficacy and safety of novel...

journal_title：Current opinion in pharmacology

authors： Feaster B,Cline A,Feldman SR,Taylor S

更新日期：2019-06-01 00:00:00

abstract：:Gasotransmitters fulfill important roles in cellular homeostasis having been linked to various pathologies, including inflammation and cardiovascular diseases. In addition to the known pathways mediating the actions of gasotransmitters, their effects in regulating mitochondrial function are emerging. Given that mitoch...

journal_title：Current opinion in pharmacology

authors： Hendriks KD,Maassen H,van Dijk PR,Henning RH,van Goor H,Hillebrands JL

更新日期：2019-04-01 00:00:00

abstract：:Despite multiple efforts to find treatments, prion diseases are still incurable. The currently available therapeutic strategies are mostly based on compounds to inhibit pathological PrP (PrPSc) accumulation, and cellular PrP (PrPC) conversion into PrPSc. However, they cannot reverse the pathological changes already pr...

journal_title：Current opinion in pharmacology

authors： Relaño-Ginés A,Lehmann S,Crozet C

更新日期：2019-02-01 00:00:00

abstract：:The evolving policies regarding the use of therapeutic Cannabis have steadily increased the public interest in its use as a complementary and alternative medicine in several disorders, including inflammatory bowel disease. Endocannabinoids represent both an appealing therapeutic strategy and a captivating scientific d...

journal_title：Current opinion in pharmacology

authors： Pesce M,Esposito G,Sarnelli G

更新日期：2018-12-01 00:00:00

abstract：:Tuberculosis now ranks as the leading cause of death in the world due to a single infectious agent. Current standard of care treatment can achieve very high cure rates for drug-sensitive disease but requires a 6-month duration of chemotherapy. Drug-resistant disease requires significantly longer treatment durations wi...

journal_title：Current opinion in pharmacology

authors： J Libardo MD,Boshoff HI,Barry CE 3rd

更新日期：2018-10-01 00:00:00

abstract：:The use and utility of computational models in drug development has significantly grown in the last decades, fostered by the availability of high throughput datasets and new data analysis strategies. These in silico approaches are demonstrating their ability to generate reliable predictions as well as new knowledge on...

journal_title：Current opinion in pharmacology

authors： Piñero J,Furlong LI,Sanz F

更新日期：2018-10-01 00:00:00

abstract：:Treatment of complex diseases such as cancer, cardiovascular disease, diabetes or neurological disorders frequently warrants the utilization of drug combinations for therapeutic intervention. In fact, the most successful example is the current standard of care for HIV patients. However, identification of successful dr...

journal_title：Current opinion in pharmacology

authors： Pemovska T,Bigenzahn JW,Superti-Furga G

更新日期：2018-10-01 00:00:00

abstract：:The deployment of artemisinin-based combination therapies (ACTs) has been, and continues to be, integral to reducing the number of malaria cases and deaths. However, their efficacy is being increasingly jeopardized by the emergence and spread of parasites that are resistant (or partially resistant) to the artemisinin ...

journal_title：Current opinion in pharmacology

authors： Martin RE,Shafik SH,Richards SN

更新日期：2018-10-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the 5th most common cancer, but the 3rd leading cause of cancer death globally with approximately 700,000 fatalities annually. The severity of this cancer arises from its difficulty to detect and treat. The major etiologies of HCC are liver fibrosis or cirrhosis from chronic viral inf...

journal_title：Current opinion in pharmacology

authors： Black AP,Mehta AS

更新日期：2018-08-01 00:00:00

abstract：:Several mechanisms of resistance have been identified, underscoring the complex nature of estrogen receptor (ER) signaling and the many connections between this pathway and other essential signaling pathways in breast cancer cells. Many therapeutic targets of cell signaling and cell cycle pathways have met success wit...

journal_title：Current opinion in pharmacology

authors： Mills JN,Rutkovsky AC,Giordano A

更新日期：2018-08-01 00:00:00

abstract：:Diabetes-induced hyperglycemia is a causal factor for cardiovascular disease (CVD) and, specifically, peripheral artery disease (PAD). Metformin is the cornerstone drug therapy for glucose-lowering that exerts beneficial effects beyond glycemic control. New glucose-lowering drugs have recently been shown cardiovascula...

journal_title：Current opinion in pharmacology

authors： Suades R,Cosentino F,Badimon L

更新日期：2018-04-01 00:00:00

abstract：:Invasive treatment in peripheral artery disease (PAD) has evolved as a viable alternative to surgical treatment. However, beyond the common pathophysiological substrate, as far as treatment is concerned, each site of atherosclerotic disease (subclavian and vertebral arteries; carotid arteries; intracranial arterial tr...

journal_title：Current opinion in pharmacology

authors： Deftereos SG,Vrachatis DA,Tolis C,Giannopoulos G

更新日期：2018-04-01 00:00:00

abstract：:Metabotropic glutamate receptors (mGluRs) are heavily expressed throughout the basal ganglia (BG), where they modulate neuronal excitability, transmitter release and long term synaptic plasticity. Therefore, targeting specific mGluR subtypes by means of selective drugs could be a possible strategy for restoring normal...

journal_title：Current opinion in pharmacology

authors： Masilamoni GJ,Smith Y

更新日期：2018-02-01 00:00:00

abstract：:In spite of the recent advancement in the molecular characterization of malignant gliomas and medulloblastomas, the treatment of primary brain tumors remains suboptimal. The use of small molecule inhibitors of intracellular signaling pathways, inhibitors of angiogenesis, and immunotherapic agents is limited by systemi...

journal_title：Current opinion in pharmacology

authors： Iacovelli L,Orlando R,Rossi A,Spinsanti P,Melchiorri D,Nicoletti F

更新日期：2018-02-01 00:00:00

abstract：:The advent of near physiological organoid technology has produced a step change in our understanding of stem cells and has provided the research community with a powerful new cell based tool to model human physiology and disease. We review the pros and cons of intestinal organoid culture systems. The molecular and gen...

journal_title：Current opinion in pharmacology

authors： Tsakmaki A,Fonseca Pedro P,Bewick GA

更新日期：2017-12-01 00:00:00

abstract：:Diseases related to bacterial infections represent a relevant challenge for public health. Despite the success obtained with the conventional antibiotic therapies, indeed, new drawbacks have been identified. In addition to poor drugs solubility and stability, adverse side effects, and many other factors which together...

journal_title：Current opinion in pharmacology

authors： Parisi OI,Scrivano L,Sinicropi MS,Puoci F

更新日期：2017-10-01 00:00:00

abstract：:In vitro surveillance data, which provide key information to interpret the results of pharmacokinetic/pharmacodynamics (PK-PD) target attainment studies, are used to support dose selection decisions and recommendations for in vitro susceptibility testing criteria for antibacterial agents during drug development. Consi...

journal_title：Current opinion in pharmacology

authors： Flamm RK,Sader HS,Castanheira M,Jones RN

更新日期：2017-10-01 00:00:00

abstract：:In the current of era of developing antibacterial agents, including those for unmet medical need, Sponsors are required to submit a robust pre-clinical pharmacokinetic-pharmacodynamic (PK-PD) data package in exchange for limited clinical data. However, the clinical data package also needs to be as robust as possible. ...

journal_title：Current opinion in pharmacology

authors： Bhavnani SM,Hammel JP

更新日期：2017-10-01 00:00:00

abstract：:Impressive remissions driven by immunological checkpoint blockade in cancer patients have prompted the scientific community to investigate afresh the crosstalk between cancer cells and the patient's immune system. Preclinical and clinical studies have highlighted that the anticancer efficacy of some conventional chemo...

journal_title：Current opinion in pharmacology

authors： Fournier C,Rivera Vargas T,Martin T,Melis A,Apetoh L

更新日期：2017-08-01 00:00:00