Monitoring vedolizumab and ustekinumab drug levels in patients with inflammatory bowel disease: hype or hope?

abstract：:Skeletal lesions contribute substantially to morbidity and mortality in patients with cancer. Emerging treatments for metastatic bone disease have arisen from our understanding of the biology of bone metastases. Tumour cells alter the functions of bone-resorbing (osteoclasts) and bone-forming (osteoblasts) cells, prom...

journal_title：Current opinion in pharmacology

authors： Clément-Demange L,Clézardin P

更新日期：2015-06-01 00:00:00

abstract：:DNA-targeted chemotherapies remain fundamental in clinical management of both common solid tumours and hematologic malignancies. Recent studies indicate that novel combinations of cytotoxic chemotherapy may have significant activity even in tumours regarded as being resistant to conventional chemotherapy. In addition,...

journal_title：Current opinion in pharmacology

authors： Hartley JA,Hochhauser D

更新日期：2012-08-01 00:00:00

abstract：:Introduction of biological agents for the treatment of the chronic inflammatory joint disease rheumatoid arthritis has reinvigorated research into this debilitating disease. These agents have been shown to both act on the signs and symptoms of disease, as well as retard the progression of joint destruction. However, t...

journal_title：Current opinion in pharmacology

authors： Blake SM,Swift BA

更新日期：2004-06-01 00:00:00

abstract：:The majority of kidney cancers are clear-cell carcinomas (ccRCC), characterized by the accumulation of cholesterol, cholesterol esters, other neutral lipids and glycogen. Rather than being a passive bystander, the clear-cell phenotype is suggested to be a biomarker of deregulated cholesterol and lipid biosynthesis, wh...

journal_title：Current opinion in pharmacology

authors： Drabkin HA,Gemmill RM

更新日期：2012-12-01 00:00:00

abstract：:Putative druggable targets to selectively enhance cardiac conduction can be considered from the level of the ion channels determining the initiation and duration of the cardiac action potential to the gap junction proteins responsible for optimal cellular electrical coupling. Nature has provided a number of inherited ...

journal_title：Current opinion in pharmacology

authors： Gomes J,Lambiase PD

更新日期：2009-04-01 00:00:00

abstract：:Bone remodelling is an essential process for shaping and maintaining bone mass in the mature skeleton. During our lifetime bone is constantly being removed by osteoclasts and new bone is formed by osteoblasts. The activities of osteoclasts and osteoblasts must be regulated under a strict balance to ensure that bone ho...

journal_title：Current opinion in pharmacology

authors： Prideaux M,Findlay DM,Atkins GJ

更新日期：2016-06-01 00:00:00

abstract：:Dietary intake of marine n-3 polyunsaturated fatty acids (PUFA) has beneficial effects in various cardiac disorders. Few studies have, however, investigated the therapeutic potential of n-3 PUFA in patients undergoing coronary artery bypass grafting (CABG). Five heterogeneous randomized studies on n-3 PUFA for prevent...

journal_title：Current opinion in pharmacology

authors： Andreasen JJ,Schmidt EB

更新日期：2012-04-01 00:00:00

abstract：:Metabotropic glutamate receptors (mGluRs) are heavily expressed throughout the basal ganglia (BG), where they modulate neuronal excitability, transmitter release and long term synaptic plasticity. Therefore, targeting specific mGluR subtypes by means of selective drugs could be a possible strategy for restoring normal...

journal_title：Current opinion in pharmacology

authors： Masilamoni GJ,Smith Y

更新日期：2018-02-01 00:00:00

abstract：:Oxidation-specific epitopes (OSE), present on oxidized LDL (OxLDL), apoptotic cells, cell debris and modified proteins in the vessel wall, accumulate in response to hypercholesterolemia, and generate potent pro-inflammatory, disease-specific antigens. They represent an important class of 'danger associated molecular p...

journal_title：Current opinion in pharmacology

authors： Leibundgut G,Witztum JL,Tsimikas S

更新日期：2013-04-01 00:00:00

abstract：:Homomerization and heteromerization of 7 transmembrane spanning (7TM)/G-protein-coupled receptors (GPCRs) have been an important field of study. Whereas initial studies were performed in artificial cell systems, recent publications are shifting the focus to the in vivo relevance of heteromerization. This is especially...

journal_title：Current opinion in pharmacology

authors： van Rijn RM,Whistler JL,Waldhoer M

更新日期：2010-02-01 00:00:00

abstract：:The first therapeutic aptamer was approved for human use in 2004, and a range of chemical substitutions that improve the drug-like properties of aptamers has recently been shown to increase the utility of this modality. Currently there are both anticoagulant and antithrombotic aptamers in the clinic, and additionally ...

journal_title：Current opinion in pharmacology

authors： Keefe AD,Schaub RG

更新日期：2008-04-01 00:00:00

abstract：:After a decade of intense pharmacological and drug development activity by the pharmaceutical industry, compounds derived from two key strategies for reducing gastrointestinal effects of non-steroidal anti-inflammatory drugs (NSAIDs) have been subjected to rigorous clinical appraisal. Despite the undoubted therapeutic...

journal_title：Current opinion in pharmacology

authors： Whittle BJ

更新日期：2004-12-01 00:00:00

abstract：:Major progress in our understanding of the mechanisms of anaesthesia has been made during the past year. Several key advances in defining very specific sites of action on ligand-gated ion channels have been described. Furthermore, new techniques have become available for addressing the identification of binding sites ...

journal_title：Current opinion in pharmacology

authors： Thompson SA,Wafford K

更新日期：2001-02-01 00:00:00

abstract：:For many years the idea of a cough center in the brain dominated discussions in the field without any substantial progress in defining what this cough center is or how it functions. Substantial progress has now been made and many of the central neural elements involved in coughing are being described. Furthermore, hyp...

journal_title：Current opinion in pharmacology

authors： Mazzone SB,McGovern AE,Cole LJ,Farrell MJ

更新日期：2011-06-01 00:00:00

abstract：:Ionotropic neurotransmitter receptors mediate fast synaptic transmission by localizing at postsynapses. Changes in receptor number at synapses induce synaptic plasticity. Thus, mechanisms for the synaptic localization of receptors in basal transmission and synaptic plasticity have been investigated extensively. Recent...

journal_title：Current opinion in pharmacology

authors： Martenson JS,Tomita S

更新日期：2015-02-01 00:00:00

abstract：:Biomedical applications of porous silicon include drug delivery, imaging, diagnostics and immunotherapy. This review summarizes new silicon particle fabrication techniques, dynamics of cellular transport, advances in the multistage vector approach to drug delivery, and the use of porous silicon as immune adjuvants. Re...

journal_title：Current opinion in pharmacology

authors： Savage DJ,Liu X,Curley SA,Ferrari M,Serda RE

更新日期：2013-10-01 00:00:00

abstract：:Protein translocation is a universal event shared by most cell signalling pathways to transmit signals between cell compartments. In recent years, the use of new fluorescence microscopy technologies combined with fluorescent probes--most often fluorescent proteins--and image analysis software has allowed the visualiza...

journal_title：Current opinion in pharmacology

authors： Furger C,Derick S,Boutin JA,Nosjean O

更新日期：2009-10-01 00:00:00

abstract：:Diabetes diagnosed in adults is a highly heterogeneous disorder. It mostly consists of what is referred to as type 2 diabetes but also comprises other entities (i.e. different diseases), including latent autoimmune diabetes, late onset forms of monogenic diabetes and familial diabetes of the adulthood, which has recen...

journal_title：Current opinion in pharmacology

authors： Trischitta V,Prudente S,Doria A

更新日期：2020-12-01 00:00:00

abstract：:Inhibition of the DNA repair enzyme poly(ADP-ribose) polymerase-1 (PARP-1) has been extensively investigated in the pre-clinical setting as a strategy for chemo- or radio-potentiation. Recent evidence has suggested that PARP inhibitors might be active as single agents in certain rare inherited cancers that carry DNA r...

journal_title：Current opinion in pharmacology

authors： Plummer ER

更新日期：2006-08-01 00:00:00

abstract：:Over the past few years small molecule inhibitors of both Src family kinases and focal adhesion kinase (FAK) have entered clinical studies for the treatment of solid tumours. These adhesion-linked kinases are involved in a number of pathways that have impact on the behaviour of tumour cells and the challenge is now, h...

journal_title：Current opinion in pharmacology

authors： Brunton VG,Frame MC

更新日期：2008-08-01 00:00:00

abstract：:Blood vessels deliver nutrients and oxygen to cells and tissues in the body. When blood supply is insufficient new vessels form to meet the metabolic tissue requirements. Several studies have examined the cellular and molecular principles of blood vessel formation, yet little is known about how vessels sense and integ...

journal_title：Current opinion in pharmacology

authors： Guarani V,Potente M

更新日期：2010-04-01 00:00:00

abstract：:Breast tumor kinase (Brk), also termed PTK6, is known to function in cell-type and context-dependent processes governing normal differentiation. However, in tumors in which Brk is overexpressed, this unusual soluble tyrosine kinase is emerging as a mediator of cancer cell phenotypes, including increased proliferation,...

journal_title：Current opinion in pharmacology

authors： Ostrander JH,Daniel AR,Lange CA

更新日期：2010-12-01 00:00:00

abstract：:Human pluripotent stem cells can be differentiated into specific, relevant cell types of interest including the cells of the retina and optic nerve. These cells can then be used to study fundamental biology as well as disease modelling and subsequent screening of potential treatments. Many models of differentiation an...

journal_title：Current opinion in pharmacology

authors： Lidgerwood GE,Hewitt AW,Pébay A

更新日期：2019-10-01 00:00:00

abstract：:CLEC-2 is a C-type lectin-like molecule that has recently been identified as a receptor on the surface of platelets. Ligand binding by CLEC-2 promotes phosphorylation of a tyrosine in the cytoplasmic domain YXXL motif of CLEC-2 by Src kinases and further downstream signalling events trigger platelet activation and agg...

journal_title：Current opinion in pharmacology

authors： O'Callaghan CA

更新日期：2009-04-01 00:00:00

abstract：:Mice rendered adenosine deaminase-deficient manifest an 'asthma' phenotype in the lungs that includes mast cell degranulation, eosinophilia, mucus hypersecretion and bronchial hyperresponsiveness. These changes can be reversed by enzyme therapy with adenosine deaminase, and attenuated by theophylline. Theophylline als...

journal_title：Current opinion in pharmacology

authors： Fozard JR

更新日期：2003-06-01 00:00:00

abstract：:Most of the G-protein-coupled receptors (GPCRs) in the human genome have been described. Investigation will now shift from discovery to analysis. Like many other genes, those encoding GPCRs are frequently found adjacent to each other in clusters. Duplicated genes often share ligands, signalling pathways and amino acid...

journal_title：Current opinion in pharmacology

authors： Foord SM

更新日期：2002-10-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis is the most common form of the interstitial lung diseases and is characterized by chronic progressive pulmonary parenchymal fibrosis. Although the diagnosis and pathophysiology of this disease have been better characterized over the past few years, there remains no effective therapy for t...

journal_title：Current opinion in pharmacology

authors： Bhatt N,Baran CP,Allen J,Magro C,Marsh CB

更新日期：2006-06-01 00:00:00

abstract：:Angiotensin II blockade has become a standard anti-fibrotic therapy in renal diseases because it slows progression to end-stage renal disease. However, current data support the notion that angiotensin II blockade alone cannot stop progressive fibrotic disease. Of an increasing number of therapies showing efficacy in a...

journal_title：Current opinion in pharmacology

authors： Yu L,Noble NA,Border WA

更新日期：2002-04-01 00:00:00

abstract：:In the current of era of developing antibacterial agents, including those for unmet medical need, Sponsors are required to submit a robust pre-clinical pharmacokinetic-pharmacodynamic (PK-PD) data package in exchange for limited clinical data. However, the clinical data package also needs to be as robust as possible. ...

journal_title：Current opinion in pharmacology

authors： Bhavnani SM,Hammel JP

更新日期：2017-10-01 00:00:00

abstract：:During the past decade, evidence has accumulated for the involvement of purines and purine receptors in the pathogenesis and pathophysiology of asthma and chronic obstructive pulmonary diseases. In particular, the indirect bronchospasmic and inflammatory actions of purines via the activation and degranulation of mast ...

journal_title：Current opinion in pharmacology

authors： Adriaensen D,Timmermans JP

更新日期：2004-06-01 00:00:00