Src and focal adhesion kinase as therapeutic targets in cancer.

abstract：:An increasing number of genetic diseases are found to result from mutations that lead to retention of the affected proteins in the endoplasmic reticulum, where they are recognized as misfolded by the quality control system. Several of these conformational diseases involve mutations in G-protein-coupled receptors. Rece...

journal_title：Current opinion in pharmacology

authors： Bernier V,Bichet DG,Bouvier M

更新日期：2004-10-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the 5th most common cancer, but the 3rd leading cause of cancer death globally with approximately 700,000 fatalities annually. The severity of this cancer arises from its difficulty to detect and treat. The major etiologies of HCC are liver fibrosis or cirrhosis from chronic viral inf...

journal_title：Current opinion in pharmacology

authors： Black AP,Mehta AS

更新日期：2018-08-01 00:00:00

abstract：:Information about the activity of airway sensory afferent nerves in vivo can be obtained electrophysiologically by extracellular recording of action potentials. Apart from data capture, the basic techniques used for recording sensory nerve activity have not advanced greatly in 50 years. However, clearly they continue ...

journal_title：Current opinion in pharmacology

authors： Adcock JJ

更新日期：2002-06-01 00:00:00

abstract：:Synthetic glucocorticoids are potent modulators of the immune system, and are clinically invaluable in the treatment of a wide variety of conditions. However, their use can be limited by harmful side effects, and their mechanisms of action remain poorly understood and controversial. It has recently been reported that ...

journal_title：Current opinion in pharmacology

authors： Clark AR,Lasa M

更新日期：2003-08-01 00:00:00

abstract：:The past decade has witnessed a growing interest in the trophic effects of antidepressant drugs. Antidepressants stimulate the production and signaling of plasticity-related proteins such as neurotrophins and cAMP response element binding protein, and neurotrophin signaling appears to be both sufficient and necessary ...

journal_title：Current opinion in pharmacology

authors： Castrén E

更新日期：2004-02-01 00:00:00

abstract：:In recent decades there has been an upsurge of interest in mechanisms of cell death in the central nervous system. Much attention has been focused on two cell death processes - excitotoxicity and apoptosis - and much confusion has arisen regarding how one relates to the other, and how either relates to neurological di...

journal_title：Current opinion in pharmacology

authors： Olney JW

更新日期：2003-02-01 00:00:00

abstract：:11beta-hydroxysteroid dehydrogenases (11beta-HSDs) catalyse the interconversion of active cortisol and inert cortisone. Two isozymes have been discovered, each with unique properties and powerful biological roles. 11beta-HSD2 potently inactivates cortisol, protecting key tissues. By contrast, 11beta-HSD1 regenerates c...

journal_title：Current opinion in pharmacology

authors： Seckl JR

更新日期：2004-12-01 00:00:00

abstract：:Several mechanisms of resistance have been identified, underscoring the complex nature of estrogen receptor (ER) signaling and the many connections between this pathway and other essential signaling pathways in breast cancer cells. Many therapeutic targets of cell signaling and cell cycle pathways have met success wit...

journal_title：Current opinion in pharmacology

authors： Mills JN,Rutkovsky AC,Giordano A

更新日期：2018-08-01 00:00:00

abstract：:Gastroesophageal reflux disease (GERD) is increasingly common worldwide; symptoms differ between individuals and endoscopically visible injury is present in only about 50% of cases. Although GERD is a disorder of gastrointestinal motility and structure, the most effective therapy is based on the use of acid antisecret...

journal_title：Current opinion in pharmacology

authors： Armstrong D

更新日期：2005-12-01 00:00:00

abstract：:Mitochondria play a key role in energy metabolism in many tissues, including skeletal muscle and liver. Inherent disorders of mitochondria such as DNA deletions cause major disruption of metabolism and can result in severe impairment or death. However, the occurrence of such disorders is extremely rare and cannot acco...

journal_title：Current opinion in pharmacology

authors： Johannsen DL,Ravussin E

更新日期：2009-12-01 00:00:00

abstract：:It has been a few decades since Ca(2+) was identified as one of the important factors that can accelerate gastric wound repair as well as contribute to epithelial homeostasis and regulation of gastric secretions. The mechanistic basis has remained largely unexplored in vivo because it was not possible to track in real...

journal_title：Current opinion in pharmacology

authors： Aihara E,Montrose MH

更新日期：2014-12-01 00:00:00

abstract：:Invasive treatment in peripheral artery disease (PAD) has evolved as a viable alternative to surgical treatment. However, beyond the common pathophysiological substrate, as far as treatment is concerned, each site of atherosclerotic disease (subclavian and vertebral arteries; carotid arteries; intracranial arterial tr...

journal_title：Current opinion in pharmacology

authors： Deftereos SG,Vrachatis DA,Tolis C,Giannopoulos G

更新日期：2018-04-01 00:00:00

abstract：:Light offers unique advantages for studying and manipulating biomolecules and the cellular processes that they control. Optical control of ionotropic and metabotropic glutamate receptors has garnered significant interest, since these receptors are central to signaling at neuronal synapses and only optical approaches p...

journal_title：Current opinion in pharmacology

authors： Reiner A,Levitz J,Isacoff EY

更新日期：2015-02-01 00:00:00

abstract：:Interferon-alpha-based therapies are the mainstay of hepatitis C treatment. However, these broad immunomodulatory agents, already limited by their side effects, expense and route of administration, are not efficacious in all cases. Therefore, research efforts have focused on identifying additional drugs and therapeuti...

journal_title：Current opinion in pharmacology

authors： Tan SL,He Y,Huang Y,Gale M Jr

更新日期：2004-10-01 00:00:00

abstract：:The advent of near physiological organoid technology has produced a step change in our understanding of stem cells and has provided the research community with a powerful new cell based tool to model human physiology and disease. We review the pros and cons of intestinal organoid culture systems. The molecular and gen...

journal_title：Current opinion in pharmacology

authors： Tsakmaki A,Fonseca Pedro P,Bewick GA

更新日期：2017-12-01 00:00:00

abstract：:In our enthusiasm to advocate apoptosis as a therapeutic strategy for the management of disease we need to be mindful that the clearance of apoptotic cells is itself immunomodulatory and that it may not always be as benign or beneficial as we think. Indeed, the existence of free apoptotic cells in situ may potentially...

journal_title：Current opinion in pharmacology

authors： Brown SB,Vernon-Wilson EF

更新日期：2005-08-01 00:00:00

abstract：:Protein translocation is a universal event shared by most cell signalling pathways to transmit signals between cell compartments. In recent years, the use of new fluorescence microscopy technologies combined with fluorescent probes--most often fluorescent proteins--and image analysis software has allowed the visualiza...

journal_title：Current opinion in pharmacology

authors： Furger C,Derick S,Boutin JA,Nosjean O

更新日期：2009-10-01 00:00:00

abstract：:Impressive remissions driven by immunological checkpoint blockade in cancer patients have prompted the scientific community to investigate afresh the crosstalk between cancer cells and the patient's immune system. Preclinical and clinical studies have highlighted that the anticancer efficacy of some conventional chemo...

journal_title：Current opinion in pharmacology

authors： Fournier C,Rivera Vargas T,Martin T,Melis A,Apetoh L

更新日期：2017-08-01 00:00:00

abstract：:Airway epithelial cells provide mechanical and immune protection against pathogens and allergens. Following activation, these cells produce a wide range of cytokines including thymic stromal lymphopoietin (TSLP). Recently it was established that a high level of TSLP is associated with asthma in mice and in humans. The...

journal_title：Current opinion in pharmacology

authors： Rochman Y,Leonard WJ

更新日期：2008-06-01 00:00:00

abstract：:Obesity is a chronic disease that increases susceptibility to various diseases, particularly cardiovascular dysfunction, type 2 diabetes, and some types of cancer. In this review, we highlighted recent evidence in mouse models that support a potential benefit of increasing adipose lipid utilization through stimulating...

journal_title：Current opinion in pharmacology

authors： Marcelin G,Chua S Jr

更新日期：2010-10-01 00:00:00

abstract：:Although a prominent cause of upper and lower respiratory tract disease in infants and the elderly, clinical options for treatment of respiratory syncytial virus (RSV) infections remain limited. Historically, attempts to develop vaccines have been unsuccessful, and rapid viral mutation rates have stifled development o...

journal_title：Current opinion in pharmacology

authors： Leaman DW

更新日期：2005-10-01 00:00:00

abstract：:The classical neurotransmitter, serotonin (5-HT), plays an important role outside of the central nervous system in immune signaling. Here I review recent studies describing 5-HT uptake in dendritic cells and B lymphocytes, 5-HT synthesis in T lymphocytes, and the role of specific 5-HT receptor subtypes in innate and a...

journal_title：Current opinion in pharmacology

authors： Ahern GP

更新日期：2011-02-01 00:00:00

abstract：:The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated Cl(-) channel expressed in epithelial cells in the airways, pancreas, intestine and other fluid-transporting tissues. Cystic fibrosis is caused by mutations in the CFTR, resulting in impaired Cl(-) transport and plasma membrane targetin...

journal_title：Current opinion in pharmacology

authors： Thiagarajah JR,Verkman AS

更新日期：2003-12-01 00:00:00

abstract：:Antimicrobial resistance is a global threat to the management of infections in our patients. Sound stewardship of antibacterial agents at our disposal must be accompanied by a concerted effort to develop new agents to bolster our armamentarium. This review will cover the latest antibiotics that have come through the p...

journal_title：Current opinion in pharmacology

authors： Gould IM,Gunasekera C,Khan A

更新日期：2019-10-01 00:00:00

abstract：:Major progress in our understanding of the mechanisms of anaesthesia has been made during the past year. Several key advances in defining very specific sites of action on ligand-gated ion channels have been described. Furthermore, new techniques have become available for addressing the identification of binding sites ...

journal_title：Current opinion in pharmacology

authors： Thompson SA,Wafford K

更新日期：2001-02-01 00:00:00

abstract：:Chronic inflammation is a risk factor for several gastrointestinal malignancies, including colorectal cancer. Recent epidemiological studies and clinical trials demonstrate that long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) markedly reduced the relative risk of colorectal cancer. Chronic inflammation...

journal_title：Current opinion in pharmacology

authors： Wang D,Dubois RN,Richmond A

更新日期：2009-12-01 00:00:00

abstract：:Inhibition of the DNA repair enzyme poly(ADP-ribose) polymerase-1 (PARP-1) has been extensively investigated in the pre-clinical setting as a strategy for chemo- or radio-potentiation. Recent evidence has suggested that PARP inhibitors might be active as single agents in certain rare inherited cancers that carry DNA r...

journal_title：Current opinion in pharmacology

authors： Plummer ER

更新日期：2006-08-01 00:00:00

abstract：:Obesity is characterized by the presence of chronic inflammation in adipose tissue, particularly in the visceral compartment, that has been causally linked to development of obesity-associated comorbidities. This link can be either direct or indirect, through induction of insulin resistance. This review summarizes rec...

journal_title：Current opinion in pharmacology

authors： Akasheh RT,Pang J,York JM,Fantuzzi G

更新日期：2013-08-01 00:00:00

abstract：:Diabetes diagnosed in adults is a highly heterogeneous disorder. It mostly consists of what is referred to as type 2 diabetes but also comprises other entities (i.e. different diseases), including latent autoimmune diabetes, late onset forms of monogenic diabetes and familial diabetes of the adulthood, which has recen...

journal_title：Current opinion in pharmacology

authors： Trischitta V,Prudente S,Doria A

更新日期：2020-12-01 00:00:00

abstract：:Cancer is one of the major growing public health problems making the development of new anti-cancer treatment strategies still compulsory. Conventionally used chemotherapies are quite often associated with severe side effects. One reason is limited cell-permeability of the used drugs resulting in only poor overall bio...

journal_title：Current opinion in pharmacology

authors： Klimpel A,Lützenburg T,Neundorf I

更新日期：2019-08-01 00:00:00