Abstract:
:Light offers unique advantages for studying and manipulating biomolecules and the cellular processes that they control. Optical control of ionotropic and metabotropic glutamate receptors has garnered significant interest, since these receptors are central to signaling at neuronal synapses and only optical approaches provide the spatial and temporal resolution required to directly probe receptor function in cells and tissue. Following the classical method of glutamate photo-uncaging, recently developed methods have added other forms of remote control, including those with high molecular specificity and genetic targeting. These tools open the door to the direct optical control of synaptic transmission and plasticity, as well as the probing of native receptor function in intact neural circuits.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Reiner A,Levitz J,Isacoff EYdoi
10.1016/j.coph.2014.12.008subject
Has Abstractpub_date
2015-02-01 00:00:00pages
135-43eissn
1471-4892issn
1471-4973pii
S1471-4892(14)00175-1journal_volume
20pub_type
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doi:10.1016/j.coph.2013.09.001
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