Two way communication between neutrophils and dendritic cells.

Abstract:

:Neutrophils are instrumental in innate immunity by mediating immediate removal of pathogens. Recent findings demonstrate that they are able to communicate with dendritic cells, which form a link between innate and adaptive immunity by stimulating long-term memory T cell responses. This communication occurs through the cell-surface receptors Mac-1 and carcinoembryonic antigen-related cellular adhesion molecule on neutrophils, which interact with C-type lectins such as dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN). Clearly, dendritic cells can prolong the lifespan of neutrophils, whereas neutrophils could direct dendritic cell-mediated T cell responses.

journal_name

Curr Opin Pharmacol

authors

Ludwig IS,Geijtenbeek TB,van Kooyk Y

doi

10.1016/j.coph.2006.03.009

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

408-13

issue

4

eissn

1471-4892

issn

1471-4973

pii

S1471-4892(06)00087-7

journal_volume

6

pub_type

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