Abstract:
:Neutrophils are instrumental in innate immunity by mediating immediate removal of pathogens. Recent findings demonstrate that they are able to communicate with dendritic cells, which form a link between innate and adaptive immunity by stimulating long-term memory T cell responses. This communication occurs through the cell-surface receptors Mac-1 and carcinoembryonic antigen-related cellular adhesion molecule on neutrophils, which interact with C-type lectins such as dendritic cell-specific ICAM-3 grabbing non-integrin (DC-SIGN). Clearly, dendritic cells can prolong the lifespan of neutrophils, whereas neutrophils could direct dendritic cell-mediated T cell responses.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Ludwig IS,Geijtenbeek TB,van Kooyk Ydoi
10.1016/j.coph.2006.03.009subject
Has Abstractpub_date
2006-08-01 00:00:00pages
408-13issue
4eissn
1471-4892issn
1471-4973pii
S1471-4892(06)00087-7journal_volume
6pub_type
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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