Abstract：
:White adipose tissue (WAT) is a highly dynamic organ that can vary considerably in mass depending on energy balance. Data from recent cross-sectional and prospective clinical studies have revealed a set of mechanisms that link WAT dysfunction to type 2 diabetes. This review focuses on three of the most important pathophysiological processes that distinguish WAT in the insulin resistant state: regional WAT distribution, adipocyte hypertrophy and lipid turnover. Together, these disturbances attenuate the lipid storage capacity of WAT leading to ectopic fat deposition in peripheral tissues such as skeletal muscle, liver and vessels ultimately leading to type 2 diabetes and cardiovascular complications. The possible approaches to therapeutically target dysfunctional WAT are also discussed.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Mejhert N,Rydén Mdoi
10.1016/j.coph.2020.09.008subject
Has Abstractpub_date
2020-12-01 00:00:00pages
47-52eissn
1471-4892issn
1471-4973pii
S1471-4892(20)30089-8journal_volume
55pub_type
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