Abstract:
:About one third of people in the world suffer from metabolic syndrome (MetS), with symptoms such as hypertension and elevated blood cholesterol, and with increased risk of developing additional diseases such as diabetes mellitus and heart disease. The progression of this multifactorial pathology, which targets various tissues and organs, might necessitate a renewal in therapeutic approaches. Since cyclic nucleotide phosphodiesterases (PDEs), enzymes which hydrolyze cyclic AMP and cyclic GMP, play a crucial role in regulating endocrine and cardiovascular functions, inflammation, oxidative stress, and cell proliferation, all of which contribute to MetS, we wonder whether PDE inhibitors might represent new therapeutic approaches for preventing and treating MetS.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Lugnier Cdoi
10.1016/j.coph.2011.09.012subject
Has Abstractpub_date
2011-12-01 00:00:00pages
698-706issue
6eissn
1471-4892issn
1471-4973pii
S1471-4892(11)00179-2journal_volume
11pub_type
杂志文章,评审abstract::Biomarker profiling is utilized to identify diagnostic and prognostic candidates for stroke. Clinical and preclinical biomarker data suggest altered circulating immune responses may illuminate the mechanisms of stroke recovery. However, the relationship between peripheral blood biomarker profile(s) and brain profiles ...
journal_title:Current opinion in pharmacology
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abstract::In recent decades there has been an upsurge of interest in mechanisms of cell death in the central nervous system. Much attention has been focused on two cell death processes - excitotoxicity and apoptosis - and much confusion has arisen regarding how one relates to the other, and how either relates to neurological di...
journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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abstract::Circadian rhythms impact cardiac and vascular pathophysiology, resulting in 24-hour patterning of symptoms and life-threatening/ending events (chronopathology), plus kinetics and dynamics of medications (chronopharmacology), resulting in administration-time differences in efficacy and safety. Scheduling medications ac...
journal_title:Current opinion in pharmacology
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doi:10.1016/j.coph.2020.10.014
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abstract::Diabetes diagnosed in adults is a highly heterogeneous disorder. It mostly consists of what is referred to as type 2 diabetes but also comprises other entities (i.e. different diseases), including latent autoimmune diabetes, late onset forms of monogenic diabetes and familial diabetes of the adulthood, which has recen...
journal_title:Current opinion in pharmacology
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abstract::Antimicrobial resistance is a global threat to the management of infections in our patients. Sound stewardship of antibacterial agents at our disposal must be accompanied by a concerted effort to develop new agents to bolster our armamentarium. This review will cover the latest antibiotics that have come through the p...
journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
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abstract::The development of genetic engineering technologies has today advanced to the point where the generation of high-affinity human antibodies against therapeutic targets is not a major hurdle. Rather, it is the selection of target molecules in, for example, cancer therapy that poses a challenge. Targets that are not mere...
journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4892(01)00070-4
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abstract::High-quality monoclonal antibodies (mAbs) with specificity for relevant disease molecules can now be produced in abundance. Anti-tumour necrosis factor-alpha therapies have set a new standard for symptom control in rheumatoid arthritis, and blockade of tumour necrosis factor has the potential to protect joints from st...
journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4892(03)00032-8
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abstract::In most situations, the angiotensin AT2-receptor (AT2R) mediates physiological actions opposing those mediated by the AT1-receptor (AT1R), including a vasorelaxant effect. Nevertheless, experimental evidence vastly supports that systemic application of AT2R-agonists is blood pressure neutral. However, stimulation of A...
journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.coph.2015.01.004
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abstract::Opiate drugs, such as morphine, are renowned for their analgesic properties. To date, opioid narcotics represent the largest and most potent class of pain relievers available to treat both acute and chronic pain conditions. The use of opiates, however, is severely limited by several adverse side effects. Upon chronic ...
journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.coph.2012.01.014
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abstract::After a decade of intense pharmacological and drug development activity by the pharmaceutical industry, compounds derived from two key strategies for reducing gastrointestinal effects of non-steroidal anti-inflammatory drugs (NSAIDs) have been subjected to rigorous clinical appraisal. Despite the undoubted therapeutic...
journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.coph.2004.08.003
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journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.coph.2017.05.003
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journal_title:Current opinion in pharmacology
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doi:10.1016/j.coph.2003.04.003
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abstract::Classical gene targeting has identified many genes important for fetal and placental development. Null mutation of these genes may lead to fetal growth restriction, malformation or embryonic death. Growth restriction of epigenetic basis can predispose to adult-onset diseases. The mechanisms underlying this process, te...
journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4892(01)00108-4
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journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4892(01)00122-9
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journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.coph.2005.02.005
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abstract::The molecular genetics of Barrett's esophagus (BE) and its evolution to esophageal adenocarcinoma (EAC) have been widely studied; however, the molecular mechanism of BE-EAC carcinogenesis has not been completely understood. MicroRNA (miRNA) is now essential to understand the molecular mechanism of cancer progression. ...
journal_title:Current opinion in pharmacology
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doi:10.1016/j.coph.2009.08.009
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abstract::A single sub-psychotomimetic dose of ketamine, an ionotropic glutamatergic n-methyl-D-aspartate (NMDA) receptor antagonist, produces a fast-acting antidepressant response in patients suffering from major depressive disorder. Depressed patients report alleviation of core symptoms within 2 h of a single low-dose intrave...
journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.coph.2014.07.009
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journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.coph.2012.06.002
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journal_title:Current opinion in pharmacology
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abstract::Mice rendered adenosine deaminase-deficient manifest an 'asthma' phenotype in the lungs that includes mast cell degranulation, eosinophilia, mucus hypersecretion and bronchial hyperresponsiveness. These changes can be reversed by enzyme therapy with adenosine deaminase, and attenuated by theophylline. Theophylline als...
journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
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journal_title:Current opinion in pharmacology
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doi:10.1016/j.coph.2012.09.004
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journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
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journal_title:Current opinion in pharmacology
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doi:10.1016/j.coph.2015.01.005
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abstract::During the past few years, a possible link between skeletal muscle contractile activity and immune changes has been established. This concept is based on the finding that exercise provokes an increase in a number of cytokines. We have suggested that cytokines and other peptides that are produced; expressed and release...
journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.coph.2008.02.005
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journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.coph.2008.03.002
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abstract::During the past decade, evidence has accumulated for the involvement of purines and purine receptors in the pathogenesis and pathophysiology of asthma and chronic obstructive pulmonary diseases. In particular, the indirect bronchospasmic and inflammatory actions of purines via the activation and degranulation of mast ...
journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.coph.2004.01.010
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