Abstract:
:During the past few years, a possible link between skeletal muscle contractile activity and immune changes has been established. This concept is based on the finding that exercise provokes an increase in a number of cytokines. We have suggested that cytokines and other peptides that are produced; expressed and released by muscle fibers and exert either paracrine or endocrine effects should be classified as 'myokines'. Human skeletal muscle has the capacity to express several myokines belonging to distinct different cytokine classes and contractile activity plays a role in regulating the expression of cytokines in skeletal muscle. In the present review, we focus on the myokines interleukin (IL)-6, IL-8 and IL-15 and their possible anti-inflammatory, immunoregulatory and metabolic roles.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Nielsen S,Pedersen BKdoi
10.1016/j.coph.2008.02.005subject
Has Abstractpub_date
2008-06-01 00:00:00pages
346-51issue
3eissn
1471-4892issn
1471-4973pii
S1471-4892(08)00030-1journal_volume
8pub_type
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