Glucose-lowering treatment in cardiovascular and peripheral artery disease.

abstract：:Diabetes diagnosed in adults is a highly heterogeneous disorder. It mostly consists of what is referred to as type 2 diabetes but also comprises other entities (i.e. different diseases), including latent autoimmune diabetes, late onset forms of monogenic diabetes and familial diabetes of the adulthood, which has recen...

journal_title：Current opinion in pharmacology

authors： Trischitta V,Prudente S,Doria A

更新日期：2020-12-01 00:00:00

abstract：:Sulfonylurea receptor 1 (SUR1) is a molecule with more diverse and critically important functions than previously recognized. Long viewed simply as a subunit involved in formation of a subset of K(ATP) channels, accumulating evidence indicates that SUR1 is newly upregulated in CNS ischemia and injury and is surprising...

journal_title：Current opinion in pharmacology

authors： Simard JM,Woo SK,Bhatta S,Gerzanich V

更新日期：2008-02-01 00:00:00

abstract：:Improvements in databases have already impacted GPCR research. The purpose of the review is to give a snapshot of the GPCR data available and provide utility examples. Consequently, this review covers a small set of major databases, including UniProt for proteins, Ensembl for genes, ChEMBL for bioactive chemistry and ...

journal_title：Current opinion in pharmacology

authors： Southan C

更新日期：2016-10-01 00:00:00

abstract：:Clostridium difficile disease is the major, known cause of nosocomial diarrhea and is an emerging cause of community-associated diarrhea. Recent outbreaks due to a strain of apparent increased virulence, BI/NAP1, and recognition of increasing metronidazole treatment failures as well as the morbidity associated with re...

journal_title：Current opinion in pharmacology

authors： Balagopal A,Sears CL

更新日期：2007-10-01 00:00:00

abstract：:Cholesterol epoxide hydrolase (ChEH) catalyzes the hydration of cholesterol-5,6-epoxides (5,6-EC) into cholestane-3β,5α,6β-triol. ChEH is a hetero-oligomeric complex called the anti-estrogen binding site (AEBS) comprising 3β-hydroxysterol-Δ(8)-Δ(7)-isomerase (D8D7I) and 3β-hydroxysterol-Δ(7)-reductase (DHCR7). D8D7I a...

journal_title：Current opinion in pharmacology

authors： Silvente-Poirot S,Poirot M

更新日期：2012-12-01 00:00:00

abstract：:Osteoporosis is a major and growing healthcare concern. When administered by daily injection, parathyroid hormone (PTH) and its N-terminal fragments and analogs are potent bone-formation agents. Teriparatide, recombinant human PTH(1-34), is likely to be the first anabolic agent approved for treating osteoporosis, desp...

journal_title：Current opinion in pharmacology

authors： Fox J

更新日期：2002-06-01 00:00:00

abstract：:In the last decade, the relationship between drug dosing and treatment efficacy for life-threatening fungal infections has been clarified by application of pharmacodynamic principles to the study of antifungal agents. Similar to antibacterials, antifungal agents can display static or cidal patterns of activity against...

journal_title：Current opinion in pharmacology

authors： Lewis RE

更新日期：2007-10-01 00:00:00

abstract：:Although only 5-10% of patients with asthma are relatively unresponsive to treatment with inhaled corticosteroids, refractory asthma represents an important condition, as these patients suffer considerable morbidity and mortality and consume a disproportionately large amount of health resource. Treatment options are l...

journal_title：Current opinion in pharmacology

authors： Berry M,Brightling C,Pavord I,Wardlaw A

更新日期：2007-06-01 00:00:00

abstract：:Osteoporosis is characterized by low bone mass and increased susceptibility to fracture. Recent in vitro studies showed that strontium ranelate, a novel agent containing two strontium atoms, acts as an effective anti-osteoporotic drug by inhibiting bone resorption by osteoclasts and promoting osteoblast replication an...

journal_title：Current opinion in pharmacology

authors： Marie PJ

更新日期：2005-12-01 00:00:00

abstract：:G-protein-coupled receptors (GPCRs), the largest family of membrane proteins, represent ideal therapeutic targets for a number of disorders and diseases. Besides cell-based assays and high throughput screening (HTS), and thanks to the availability of milligram quantities of active purified receptors, protein-based app...

journal_title：Current opinion in pharmacology

authors： Alkhalfioui F,Magnin T,Wagner R

更新日期：2009-10-01 00:00:00

abstract：:Over the past few years small molecule inhibitors of both Src family kinases and focal adhesion kinase (FAK) have entered clinical studies for the treatment of solid tumours. These adhesion-linked kinases are involved in a number of pathways that have impact on the behaviour of tumour cells and the challenge is now, h...

journal_title：Current opinion in pharmacology

authors： Brunton VG,Frame MC

更新日期：2008-08-01 00:00:00

abstract：:In vitro surveillance data, which provide key information to interpret the results of pharmacokinetic/pharmacodynamics (PK-PD) target attainment studies, are used to support dose selection decisions and recommendations for in vitro susceptibility testing criteria for antibacterial agents during drug development. Consi...

journal_title：Current opinion in pharmacology

authors： Flamm RK,Sader HS,Castanheira M,Jones RN

更新日期：2017-10-01 00:00:00

abstract：:Mice rendered adenosine deaminase-deficient manifest an 'asthma' phenotype in the lungs that includes mast cell degranulation, eosinophilia, mucus hypersecretion and bronchial hyperresponsiveness. These changes can be reversed by enzyme therapy with adenosine deaminase, and attenuated by theophylline. Theophylline als...

journal_title：Current opinion in pharmacology

authors： Fozard JR

更新日期：2003-06-01 00:00:00

abstract：:Therapeutic drug monitoring (TDM) plays a vital role in implementing precision medicine in inflammatory bowel disease (IBD), and may contribute to increased effectiveness, lower rates of drug toxicity and cost savings. While expert panels advocate the use of reactive TDM for anti-tumor necrosis factor (anti-TNF) agent...

journal_title：Current opinion in pharmacology

authors： Alsoud D,Vermeire S,Verstockt B

更新日期：2020-12-01 00:00:00

abstract：:Myocardial apoptosis primarily triggered during reperfusion has been associated with cardiac dysfunction and extension of infarction. Although potential signaling pathways involved in triggering apoptosis remain to be clearly defined, an increasing number of experiments have implicated the generation of reactive oxyge...

journal_title：Current opinion in pharmacology

authors： Zhao ZQ

更新日期：2004-04-01 00:00:00

abstract：:About one third of people in the world suffer from metabolic syndrome (MetS), with symptoms such as hypertension and elevated blood cholesterol, and with increased risk of developing additional diseases such as diabetes mellitus and heart disease. The progression of this multifactorial pathology, which targets various...

journal_title：Current opinion in pharmacology

authors： Lugnier C

更新日期：2011-12-01 00:00:00

abstract：:The CD28 and B7 protein families are critical regulators of immune responses and, in the past few years, several new family members have been identified. Preclinical studies exploring the role of members of the CD28 and B7 families support the targeting of these pathways for new therapeutic approaches. Indeed, recent ...

journal_title：Current opinion in pharmacology

authors： Carreno BM,Carter LL,Collins M

更新日期：2005-08-01 00:00:00

abstract：:Human pluripotent stem cells can be differentiated into specific, relevant cell types of interest including the cells of the retina and optic nerve. These cells can then be used to study fundamental biology as well as disease modelling and subsequent screening of potential treatments. Many models of differentiation an...

journal_title：Current opinion in pharmacology

authors： Lidgerwood GE,Hewitt AW,Pébay A

更新日期：2019-10-01 00:00:00

abstract：:A single sub-psychotomimetic dose of ketamine, an ionotropic glutamatergic n-methyl-D-aspartate (NMDA) receptor antagonist, produces a fast-acting antidepressant response in patients suffering from major depressive disorder. Depressed patients report alleviation of core symptoms within 2 h of a single low-dose intrave...

journal_title：Current opinion in pharmacology

authors： Kavalali ET,Monteggia LM

更新日期：2015-02-01 00:00:00

abstract：:The activation of airway afferent neurons initiates a variety of reflexes including cough and bronchoconstriction. Like somatic afferent neurons involved in inflammation-induced hyperalgesia, the excitability of airway afferent neurons is not fixed but, rather, can be increased by the action of a variety of mediators ...

journal_title：Current opinion in pharmacology

authors： Carr MJ,Ellis JL

更新日期：2002-06-01 00:00:00

abstract：:The evolving policies regarding the use of therapeutic Cannabis have steadily increased the public interest in its use as a complementary and alternative medicine in several disorders, including inflammatory bowel disease. Endocannabinoids represent both an appealing therapeutic strategy and a captivating scientific d...

journal_title：Current opinion in pharmacology

authors： Pesce M,Esposito G,Sarnelli G

更新日期：2018-12-01 00:00:00

abstract：:Since its discovery in 1993 and subsequent development of selective antagonists, a growing number of studies support the use of serotonin 5-HT(6) receptor antagonism as a promising mechanism for treating cognitive dysfunction. Lately, several studies with structurally different compounds have shown that not only antag...

journal_title：Current opinion in pharmacology

authors： Codony X,Vela JM,Ramírez MJ

更新日期：2011-02-01 00:00:00

abstract：:Biomarker profiling is utilized to identify diagnostic and prognostic candidates for stroke. Clinical and preclinical biomarker data suggest altered circulating immune responses may illuminate the mechanisms of stroke recovery. However, the relationship between peripheral blood biomarker profile(s) and brain profiles ...

journal_title：Current opinion in pharmacology

authors： Asano S,Chantler PD,Barr TL

更新日期：2016-02-01 00:00:00

abstract：:The deployment of artemisinin-based combination therapies (ACTs) has been, and continues to be, integral to reducing the number of malaria cases and deaths. However, their efficacy is being increasingly jeopardized by the emergence and spread of parasites that are resistant (or partially resistant) to the artemisinin ...

journal_title：Current opinion in pharmacology

authors： Martin RE,Shafik SH,Richards SN

更新日期：2018-10-01 00:00:00

abstract：:Reporter-gene assays offer an alternative to biochemical assays for following signal transduction pathways from receptors at the cell surface to nuclear gene transcription in living cells. Specific reporter-gene systems are now available for the study of ligand activity at G alpha(i/o), G alpha(s) and G alpha(q) G-pro...

journal_title：Current opinion in pharmacology

authors： Hill SJ,Baker JG,Rees S

更新日期：2001-10-01 00:00:00

abstract：:Despite multiple efforts to find treatments, prion diseases are still incurable. The currently available therapeutic strategies are mostly based on compounds to inhibit pathological PrP (PrPSc) accumulation, and cellular PrP (PrPC) conversion into PrPSc. However, they cannot reverse the pathological changes already pr...

journal_title：Current opinion in pharmacology

authors： Relaño-Ginés A,Lehmann S,Crozet C

更新日期：2019-02-01 00:00:00

abstract：:Somatostatin (SOM) is a regulatory peptide produced throughout the central nervous system and in most major peripheral organs. In humans, the SOM stable analogue octreotide (OCT) is used to treat opioid-resistant pain. In animal models, SOM and OCT are analgesics and SOM released from the peripheral endings of sensory...

journal_title：Current opinion in pharmacology

authors： Malcangio M

更新日期：2003-02-01 00:00:00

abstract：:The use and utility of computational models in drug development has significantly grown in the last decades, fostered by the availability of high throughput datasets and new data analysis strategies. These in silico approaches are demonstrating their ability to generate reliable predictions as well as new knowledge on...

journal_title：Current opinion in pharmacology

authors： Piñero J,Furlong LI,Sanz F

更新日期：2018-10-01 00:00:00

abstract：:Asthma is the most common chronic illness in childhood with challenges that revolve around interventions that can potentially alter the course of the disease and concerns regarding the safety of regular use of controller medications. Recent studies suggest that the use of inhaled corticosteroids in very young children...

journal_title：Current opinion in pharmacology

authors： Quizon A,Colin AA

更新日期：2010-06-01 00:00:00

abstract：:Clinical trials of selective small-molecule inhibitors of epidermal growth factor receptor tyrosine kinase activity have shown that these targeted inhibitors of proliferative signal transduction provide well-tolerated antitumour activity in patients. Preclinical pharmacology studies illustrate the potential use of the...

journal_title：Current opinion in pharmacology

authors： Wakeling AE

更新日期：2002-08-01 00:00:00