The study of airway primary afferent neuron excitability.


:The activation of airway afferent neurons initiates a variety of reflexes including cough and bronchoconstriction. Like somatic afferent neurons involved in inflammation-induced hyperalgesia, the excitability of airway afferent neurons is not fixed but, rather, can be increased by the action of a variety of mediators produced during inflammation. A variety of techniques have been applied to study the pharmacological modulation of the excitability of afferent neurons. Although airway afferent neurons have not been studied to the same extent as fibers involved in hyperalgesia, similar pathways may control their excitability. The ability to study the pharmacological modulation of airway afferent neuron excitability is crucial to our understanding of airway afferent neurophysiology and may also provide insight into novel therapeutic targets for various inflammatory lung diseases.


Curr Opin Pharmacol


Carr MJ,Ellis JL





Has Abstract


2002-06-01 00:00:00














  • Retrieving GPCR data from public databases.

    abstract::Improvements in databases have already impacted GPCR research. The purpose of the review is to give a snapshot of the GPCR data available and provide utility examples. Consequently, this review covers a small set of major databases, including UniProt for proteins, Ensembl for genes, ChEMBL for bioactive chemistry and ...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Southan C

    更新日期:2016-10-01 00:00:00

  • Recent advances in the non-invasive assessment of fibrosis using biomarkers.

    abstract::Fibrosis can occur in most organs and is characterised by excessive and progressive extracellular matrix deposition and destruction of normal tissue architecture and function. In many cases treatment options are limited. Fibrotic diseases are therefore associated with high morbidity and mortality. Tissue biopsies rema...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Tatler AL

    更新日期:2019-12-01 00:00:00

  • Non-neuronal cholinergic airway epithelium biology.

    abstract::Acetylcholine, a major regulator of airway function, is not solely produced by neurons but also by a variety of non-neurons cells including various airway epithelial cells utilizing a molecular machinery of acetylcholine synthesis and release that differs from that of neurons. While canonical neuronal cholinergic sign...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Kummer W,Krasteva-Christ G

    更新日期:2014-06-01 00:00:00

  • The role of tissue factor/factor VIIa in the pathophysiology of acute thrombotic formation.

    abstract::Tissue factor (TF) is the essential cofactor for the coagulation protease factor VIIa (FVIIa), initiating the coagulation cascade. The role of TF in thrombotic diseases is becoming increasingly evident. Recent findings suggest that inhibition of TF/FVIIa activity could be important in the prevention of clinical sequel...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Girard TJ,Nicholson NS

    更新日期:2001-04-01 00:00:00

  • The role of chemokines in intestinal inflammation and cancer.

    abstract::Chronic inflammation is a risk factor for several gastrointestinal malignancies, including colorectal cancer. Recent epidemiological studies and clinical trials demonstrate that long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) markedly reduced the relative risk of colorectal cancer. Chronic inflammation...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Wang D,Dubois RN,Richmond A

    更新日期:2009-12-01 00:00:00

  • Psychological side effects of immune therapies: symptoms and pathomechanism.

    abstract::Immunotherapies revolutionised the treatment of several disorders but show specific side-effect profiles which frequently involve psychological symptoms. Long term interferon-alpha (IFN-alpha) therapy can cause wide-ranging psychiatric side-effects from fatigue, insomnia, anxiety to full-blown depression. This treatme...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Kovacs D,Kovacs P,Eszlari N,Gonda X,Juhasz G

    更新日期:2016-08-01 00:00:00

  • Assaying dissociable elements of behavioural inhibition and impulsivity: translational utility of animal models.

    abstract::Inhibition is a fundamental property of behaviour required for flexible responding and humans have evolved executive brain systems that can engage inhibitory processes in order to reduce interference from irrelevant distracting stimuli, block unwanted memories and emotions and suppress inappropriate choices and action...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Humby T,Wilkinson LS

    更新日期:2011-10-01 00:00:00

  • Image-free assessment of protein translocation in live cells.

    abstract::Protein translocation is a universal event shared by most cell signalling pathways to transmit signals between cell compartments. In recent years, the use of new fluorescence microscopy technologies combined with fluorescent probes--most often fluorescent proteins--and image analysis software has allowed the visualiza...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Furger C,Derick S,Boutin JA,Nosjean O

    更新日期:2009-10-01 00:00:00

  • Immunomodulation in stem-cell transplantation.

    abstract::Acute graft-versus-host disease is a complication that affects 30-60% of patients undergoing allogeneic stem-cell transplantation. The standard for prophylaxis for graft-versus-host disease has historically been the combination of cyclosporine and methotrexate. Recently, tacrolimus has been used more frequently and cu...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Abo-Zena RA,Horwitz ME

    更新日期:2002-08-01 00:00:00

  • Strategies for hepatitis C therapeutic intervention: now and next.

    abstract::Interferon-alpha-based therapies are the mainstay of hepatitis C treatment. However, these broad immunomodulatory agents, already limited by their side effects, expense and route of administration, are not efficacious in all cases. Therefore, research efforts have focused on identifying additional drugs and therapeuti...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Tan SL,He Y,Huang Y,Gale M Jr

    更新日期:2004-10-01 00:00:00

  • Role of the P2X4 receptor in neuropathic pain.

    abstract::Neuropathic pain is the most important type of chronic pain because it is refractory to available medications. Neuropathic pain occurs after peripheral nerve injury (PNI) or nerve damage by various reasons. In recent decades, a growing body of evidence shows that spinal microglia and P2X4 receptor (P2X4R), a subtype o...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Inoue K

    更新日期:2019-08-01 00:00:00

  • Dopamine D2-D3 receptor heteromers: pharmacological properties and therapeutic significance.

    abstract::Heteromerization of dopamine receptors has been shown for both the D(1)/D(5) and D(2)/D(3)/D(4) receptor families, which couple positively and negatively, respectively, to adenylyl cyclase. The present article reviews data on dopamine heteromers formed by D(3), focusing in particular on associations with their D(2) co...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Maggio R,Millan MJ

    更新日期:2010-02-01 00:00:00

  • Cell death and cancer therapy.

    abstract::Successful cancer therapy requires the selective killing of cancer cells. Many molecular components of the pathways that lead to cell death have recently been identified and a number of these, including p53, Apaf-1, and members of the inhibitor of apoptosis protein and Bcl-2 gene families, have been found to be altere...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Bunz F

    更新日期:2001-08-01 00:00:00

  • From purified GPCRs to drug discovery: the promise of protein-based methodologies.

    abstract::G-protein-coupled receptors (GPCRs), the largest family of membrane proteins, represent ideal therapeutic targets for a number of disorders and diseases. Besides cell-based assays and high throughput screening (HTS), and thanks to the availability of milligram quantities of active purified receptors, protein-based app...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Alkhalfioui F,Magnin T,Wagner R

    更新日期:2009-10-01 00:00:00

  • Pharmacology on microfluidics: multimodal analysis for studying cell-cell interaction.

    abstract::Understanding the mechanisms of cell-cell interaction is a key unanswered question in modern pharmacology, given crosstalk defects are at the basis of many pathologies. Microfluidics represents a valuable tool for analyzing intercellular communication mediated by transmission of soluble signals, as occurring for examp...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Delamarche E,Tonna N,Lovchik RD,Bianco F,Matteoli M

    更新日期:2013-10-01 00:00:00

  • Treatment of orthostatic hypotension.

    abstract::Orthostatic hypotension (OH) is a fall in blood pressure after assuming an upright position. Whereas asymptomatic patients usually need no treatment, the majority of symptomatic patients can be cured by avoidance of trigger mechanisms and the use of physical countermaneuvers and non-pharmacological interventions. Seve...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Oldenburg O,Kribben A,Baumgart D,Philipp T,Erbel R,Cohen MV

    更新日期:2002-12-01 00:00:00

  • Opioid-receptor-heteromer-specific trafficking and pharmacology.

    abstract::Homomerization and heteromerization of 7 transmembrane spanning (7TM)/G-protein-coupled receptors (GPCRs) have been an important field of study. Whereas initial studies were performed in artificial cell systems, recent publications are shifting the focus to the in vivo relevance of heteromerization. This is especially...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: van Rijn RM,Whistler JL,Waldhoer M

    更新日期:2010-02-01 00:00:00

  • Heteromerization of dopamine D2 receptors with dopamine D1 or D5 receptors generates intracellular calcium signaling by different mechanisms.

    abstract::The repertoire of signal transduction pathways activated by dopamine in brain includes the increase of intracellular calcium. However the mechanism(s) by which dopamine activated this important second messenger system was/were unknown. Although we showed that activation of the D5 dopamine receptor increased calcium co...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Hasbi A,O'Dowd BF,George SR

    更新日期:2010-02-01 00:00:00

  • GDNF and somatostatin in sensory neurones.

    abstract::Somatostatin (SOM) is a regulatory peptide produced throughout the central nervous system and in most major peripheral organs. In humans, the SOM stable analogue octreotide (OCT) is used to treat opioid-resistant pain. In animal models, SOM and OCT are analgesics and SOM released from the peripheral endings of sensory...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Malcangio M

    更新日期:2003-02-01 00:00:00

  • Biased ligands: pathway validation for novel GPCR therapeutics.

    abstract::G protein-coupled receptors (GPCRs), in recent years, have been shown to signal via multiple distinct pathways. Furthermore, biased ligands for some receptors can differentially stimulate or inhibit these pathways versus unbiased endogenous ligands or drugs. Biased ligands can be used to gain a deeper understanding of...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Rominger DH,Cowan CL,Gowen-MacDonald W,Violin JD

    更新日期:2014-06-01 00:00:00

  • Therapeutic strategies to halt renal fibrosis.

    abstract::Angiotensin II blockade has become a standard anti-fibrotic therapy in renal diseases because it slows progression to end-stage renal disease. However, current data support the notion that angiotensin II blockade alone cannot stop progressive fibrotic disease. Of an increasing number of therapies showing efficacy in a...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Yu L,Noble NA,Border WA

    更新日期:2002-04-01 00:00:00

  • VEGF as a potential target for therapeutic intervention in depression.

    abstract::Antidepressants are among the most widely prescribed drugs, however the mechanism underlying their therapeutic efficacy is not known. Neurotrophic factors represent a promising class of targets for antidepressant treatments. We recently characterized a role for vascular endothelial growth factor (VEGF) in cellular and...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Warner-Schmidt JL,Duman RS

    更新日期:2008-02-01 00:00:00

  • Two way communication between neutrophils and dendritic cells.

    abstract::Neutrophils are instrumental in innate immunity by mediating immediate removal of pathogens. Recent findings demonstrate that they are able to communicate with dendritic cells, which form a link between innate and adaptive immunity by stimulating long-term memory T cell responses. This communication occurs through the...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Ludwig IS,Geijtenbeek TB,van Kooyk Y

    更新日期:2006-08-01 00:00:00

  • Human therapeutic antibodies.

    abstract::The development of genetic engineering technologies has today advanced to the point where the generation of high-affinity human antibodies against therapeutic targets is not a major hurdle. Rather, it is the selection of target molecules in, for example, cancer therapy that poses a challenge. Targets that are not mere...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Borrebaeck CA,Carlsson R

    更新日期:2001-08-01 00:00:00

  • Angiotensin type 2 receptors: blood pressure regulation and end organ damage.

    abstract::In most situations, the angiotensin AT2-receptor (AT2R) mediates physiological actions opposing those mediated by the AT1-receptor (AT1R), including a vasorelaxant effect. Nevertheless, experimental evidence vastly supports that systemic application of AT2R-agonists is blood pressure neutral. However, stimulation of A...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Sumners C,de Kloet AD,Krause EG,Unger T,Steckelings UM

    更新日期:2015-04-01 00:00:00

  • PET imaging: implications for the future of therapy monitoring with PET/CT in oncology.

    abstract::Among the methods based on molecular imaging, the measure of the tracer uptake variation between a baseline and follow-up scan with the SUV and [(18)F]FDG-PET/CT is a very powerful tool for assessing response to treatment in oncology. However, the development of new targeted therapeutics and tissue pharmacokinetic eva...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Tomasi G,Rosso L

    更新日期:2012-10-01 00:00:00

  • The brain hypocretins and their receptors: mediators of allostatic arousal.

    abstract::The hypocretins (abbreviated 'Hcrts' - also called 'orexins') are two neuropeptides secreted exclusively by a small population of neurons in the lateral hypothalamus. These peptides bind to two receptors located throughout the brain in nuclei associated with diverse cognitive and physiological functions. Initially, th...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Carter ME,Schaich Borg J,de Lecea L

    更新日期:2009-02-01 00:00:00

  • Cyclooxygenase and nitric oxide systems in the gut as therapeutic targets for safer anti-inflammatory drugs.

    abstract::After a decade of intense pharmacological and drug development activity by the pharmaceutical industry, compounds derived from two key strategies for reducing gastrointestinal effects of non-steroidal anti-inflammatory drugs (NSAIDs) have been subjected to rigorous clinical appraisal. Despite the undoubted therapeutic...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Whittle BJ

    更新日期:2004-12-01 00:00:00

  • A role for the gut-to-brain GLP-1-dependent axis in the control of metabolism.

    abstract::Over the past years tremendous amounts of clinical and fundamental data have been generated about GLP-1 and related therapeutic strategies for the treatment of type 2 diabetes. However, the cellular and physiological mechanisms through which GLP-1 is secreted, controls glycemia, and behaves as a therapeutic agent are ...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Burcelin R,Serino M,Cabou C

    更新日期:2009-12-01 00:00:00

  • Opportunistic infections in lung disease: Pseudomonas infections in cystic fibrosis.

    abstract::Pseudomonas aeruginosa is an opportunistic pathogen that significantly contributes to morbidity and mortality in patients with cystic fibrosis. Defective mucociliary clearance associated with the absence of the functional cystic fibrosis transmembrane conductance regulator in airway epithelium plays a critical role in...

    journal_title:Current opinion in pharmacology

    pub_type: 杂志文章,评审


    authors: Gómez MI,Prince A

    更新日期:2007-06-01 00:00:00