Abstract：
:The activation of airway afferent neurons initiates a variety of reflexes including cough and bronchoconstriction. Like somatic afferent neurons involved in inflammation-induced hyperalgesia, the excitability of airway afferent neurons is not fixed but, rather, can be increased by the action of a variety of mediators produced during inflammation. A variety of techniques have been applied to study the pharmacological modulation of the excitability of afferent neurons. Although airway afferent neurons have not been studied to the same extent as fibers involved in hyperalgesia, similar pathways may control their excitability. The ability to study the pharmacological modulation of airway afferent neuron excitability is crucial to our understanding of airway afferent neurophysiology and may also provide insight into novel therapeutic targets for various inflammatory lung diseases.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Carr MJ,Ellis JLdoi
10.1016/s1471-4892(02)00147-9keywords:
subject
Has Abstractpub_date
2002-06-01 00:00:00pages
216-9issue
3eissn
1471-4892issn
1471-4973pii
S1471489202001479journal_volume
2pub_type
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