The study of airway primary afferent neuron excitability.

Abstract:

:The activation of airway afferent neurons initiates a variety of reflexes including cough and bronchoconstriction. Like somatic afferent neurons involved in inflammation-induced hyperalgesia, the excitability of airway afferent neurons is not fixed but, rather, can be increased by the action of a variety of mediators produced during inflammation. A variety of techniques have been applied to study the pharmacological modulation of the excitability of afferent neurons. Although airway afferent neurons have not been studied to the same extent as fibers involved in hyperalgesia, similar pathways may control their excitability. The ability to study the pharmacological modulation of airway afferent neuron excitability is crucial to our understanding of airway afferent neurophysiology and may also provide insight into novel therapeutic targets for various inflammatory lung diseases.

journal_name

Curr Opin Pharmacol

authors

Carr MJ,Ellis JL

doi

10.1016/s1471-4892(02)00147-9

keywords:

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

216-9

issue

3

eissn

1471-4892

issn

1471-4973

pii

S1471489202001479

journal_volume

2

pub_type

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