Abstract：
:The deployment of artemisinin-based combination therapies (ACTs) has been, and continues to be, integral to reducing the number of malaria cases and deaths. However, their efficacy is being increasingly jeopardized by the emergence and spread of parasites that are resistant (or partially resistant) to the artemisinin derivatives and to their partner drugs, with the efficacy of the latter being especially crucial for treatment success. A detailed understanding of the genetic determinants of resistance to the ACT partner drugs, and the mechanisms by which they mediate resistance, is required for the surveillance of molecular markers and to optimize the efficacy and lifespan of the partner drugs through resistance management strategies. We summarize new insights into the molecular basis of parasite resistance to the ACTs, such as recently-uncovered determinants of parasite susceptibility to the artemisinin derivatives, piperaquine, lumefantrine, and mefloquine, and outline the mechanisms through which polymorphisms in these determinants may be conferring resistance.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Martin RE,Shafik SH,Richards SNdoi
10.1016/j.coph.2018.07.010subject
Has Abstractpub_date
2018-10-01 00:00:00pages
71-80eissn
1471-4892issn
1471-4973pii
S1471-4892(18)30044-4journal_volume
42pub_type
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