Abstract:
:Reporter-gene assays offer an alternative to biochemical assays for following signal transduction pathways from receptors at the cell surface to nuclear gene transcription in living cells. Specific reporter-gene systems are now available for the study of ligand activity at G alpha(i/o), G alpha(s) and G alpha(q) G-protein-coupled receptors. In recent years reporter genes have been applied in academia and industry to the study of ligand efficacy and affinity in recombinant and primary cell lines using a variety of colour, fluorescent or luminescent read-outs.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Hill SJ,Baker JG,Rees Sdoi
10.1016/s1471-4892(01)00091-1keywords:
subject
Has Abstractpub_date
2001-10-01 00:00:00pages
526-32issue
5eissn
1471-4892issn
1471-4973pii
S1471-4892(01)00091-1journal_volume
1pub_type
杂志文章,评审abstract::Increased understanding of gastrointestinal pathophysiology in functional bowel disorders is leading to improved focus on relevant enteric, vagal and spinal afferent nervous systems, and targets operating on these systems. These targets include receptors for tachykinins, motilin, ghrelin, corticotropin-releasing facto...
journal_title:Current opinion in pharmacology
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abstract::Neutrophils are instrumental in innate immunity by mediating immediate removal of pathogens. Recent findings demonstrate that they are able to communicate with dendritic cells, which form a link between innate and adaptive immunity by stimulating long-term memory T cell responses. This communication occurs through the...
journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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abstract::Chronic vulnerability to relapse is a formidable challenge for the treatment of drug addiction. The neurobiological basis of relapse and its prevention has, therefore, attracted major attention in addiction research. Current conceptualizations of addiction recognize craving as a central driving force for ongoing drug ...
journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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更新日期:2013-10-01 00:00:00
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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abstract::Irritable bowel syndrome, which affects 5-10% of the population includes around 25% with predominantly diarrhoea (IBS-D). Several lines of evidence suggest an increase in mucosal 5-HT availability in IBS-D including a decrease in the serotonin transporter (SERT) which is also seen following acute diverticulitis. 5-HT(...
journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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abstract::Improvements in databases have already impacted GPCR research. The purpose of the review is to give a snapshot of the GPCR data available and provide utility examples. Consequently, this review covers a small set of major databases, including UniProt for proteins, Ensembl for genes, ChEMBL for bioactive chemistry and ...
journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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abstract::Calcitonin gene related peptide (CGRP) has been proposed to contribute to pain transmission and inflammation and for these reasons to the mechanism of migraine. CGRP is, in fact, expressed in and released from a subset of polymodal primary sensory neurons of the trigeminal ganglion. Release of CGRP in the dorsal spina...
journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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abstract::In the last decade, the relationship between drug dosing and treatment efficacy for life-threatening fungal infections has been clarified by application of pharmacodynamic principles to the study of antifungal agents. Similar to antibacterials, antifungal agents can display static or cidal patterns of activity against...
journal_title:Current opinion in pharmacology
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abstract::Cancer is one of the major growing public health problems making the development of new anti-cancer treatment strategies still compulsory. Conventionally used chemotherapies are quite often associated with severe side effects. One reason is limited cell-permeability of the used drugs resulting in only poor overall bio...
journal_title:Current opinion in pharmacology
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abstract::The second messenger, cAMP, is one of the most important regulatory signals for control of steroidogenesis. This review focuses on current knowledge about regulation of cyclic nucleotides by phosphodiesterases (PDEs) in steroidogenic tissues. The first PDE known to directly regulate steroidogenesis was PDE2, the cGMP-...
journal_title:Current opinion in pharmacology
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abstract:PURPOSE OF THE REVIEW:Faecal microbiota transplantation (FMT) has emerged as a potent form of therapeutic microbial manipulation. There is much interest in exploring its potential in conditions such as inflammatory bowel disease (IBD) where disturbances in the gastrointestinal microbiota play a crucial role in disease ...
journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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