Abstract:
:Understanding the mechanisms of cell-cell interaction is a key unanswered question in modern pharmacology, given crosstalk defects are at the basis of many pathologies. Microfluidics represents a valuable tool for analyzing intercellular communication mediated by transmission of soluble signals, as occurring for example between neurons and glial cells in neuroinflammation, or between tumor and surrounding cells in cancer. However, the use of microfluidics for studying cell behavior still encompasses many technical and biological challenges. In this review, a state of the art of successes, potentials and limitations of microfluidics applied to key biological questions in modern pharmacology is analyzed and commented.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Delamarche E,Tonna N,Lovchik RD,Bianco F,Matteoli Mdoi
10.1016/j.coph.2013.07.005subject
Has Abstractpub_date
2013-10-01 00:00:00pages
821-8issue
5eissn
1471-4892issn
1471-4973pii
S1471-4892(13)00142-2journal_volume
13pub_type
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