Abstract：
:Despite multiple efforts to find treatments, prion diseases are still incurable. The currently available therapeutic strategies are mostly based on compounds to inhibit pathological PrP (PrPSc) accumulation, and cellular PrP (PrPC) conversion into PrPSc. However, they cannot reverse the pathological changes already present in the brain. Cell-based therapeutic strategies could promote the repair of the pre-existing brain damage. The few available data come mostly from preclinical studies using neural stem cells, bone marrow-derived microglia and mesenchymal stem cells, as cell sources. Moreover, the benefits of cell-based therapeutic strategies could be linked not only to the replacement of damaged cells, but also to the secretion of trophic factors by the grafted cells that might modulate inflammation, cell death, or endogenous neurogenesis.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Relaño-Ginés A,Lehmann S,Crozet Cdoi
10.1016/j.coph.2018.11.001subject
Has Abstractpub_date
2019-02-01 00:00:00pages
8-14eissn
1471-4892issn
1471-4973pii
S1471-4892(18)30042-0journal_volume
44pub_type
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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