Abstract:
:MicroRNAs (miRs) have recently emerged as a novel class of gene expression regulators. The number of studies documenting an altered miR expression pattern in cancer continues to expand rapidly. Critical information is continuously gained regarding how aberrantly expressed miRs contribute to carcinogenesis. Current studies provide evidence that analyses of miR expression patterns have potential clinical applications toward developing tumor biomarkers to identify the presence and dissemination of esophageal cancer, as well as to assess tumor chemosensitivity or radiosensitivity. The incidence of esophageal cancer is on the rise, and this disease continues to portend a poor prognosis. The current review addresses ways in which altered miR expression contributes to esophageal carcinogenesis, along with how recent discoveries may be applied clinically.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
David S,Meltzer SJdoi
10.1016/j.coph.2011.09.006subject
Has Abstractpub_date
2011-12-01 00:00:00pages
612-6issue
6eissn
1471-4892issn
1471-4973pii
S1471-4892(11)00173-1journal_volume
11pub_type
杂志文章,评审abstract::The majority of kidney cancers are clear-cell carcinomas (ccRCC), characterized by the accumulation of cholesterol, cholesterol esters, other neutral lipids and glycogen. Rather than being a passive bystander, the clear-cell phenotype is suggested to be a biomarker of deregulated cholesterol and lipid biosynthesis, wh...
journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
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abstract::Heteromerization of dopamine receptors has been shown for both the D(1)/D(5) and D(2)/D(3)/D(4) receptor families, which couple positively and negatively, respectively, to adenylyl cyclase. The present article reviews data on dopamine heteromers formed by D(3), focusing in particular on associations with their D(2) co...
journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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doi:10.1016/j.coph.2007.12.008
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journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.coph.2007.03.001
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abstract::The pharmaceutical industry is currently abandoning its antibacterial discovery research efforts. This seems to be part of a cyclical pattern in this therapeutic area. The reasons behind these ongoing cycles of feast and famine are multiple, but most revolve around the perception of market opportunities from the conti...
journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.coph.2003.04.003
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abstract::Most of the G-protein-coupled receptors (GPCRs) in the human genome have been described. Investigation will now shift from discovery to analysis. Like many other genes, those encoding GPCRs are frequently found adjacent to each other in clusters. Duplicated genes often share ligands, signalling pathways and amino acid...
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doi:10.1016/s1471-4892(02)00214-x
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journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.coph.2008.07.012
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journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
doi:10.1016/s1471-4892(03)00073-0
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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abstract::The advent of near physiological organoid technology has produced a step change in our understanding of stem cells and has provided the research community with a powerful new cell based tool to model human physiology and disease. We review the pros and cons of intestinal organoid culture systems. The molecular and gen...
journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
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journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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doi:10.1016/j.coph.2006.11.007
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abstract::Heart disease is the most common cause of death in patients with chronic kidney disease (CKD), particularly in those receiving dialysis. Atherosclerosic cardiovascular (CV) disease (CVD) accounts for a large number of these deaths. Atherosclerosis is accelerated in patients with CKD due predominantly to the high preva...
journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.coph.2012.12.001
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journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.coph.2005.01.005
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abstract::The activation of airway afferent neurons initiates a variety of reflexes including cough and bronchoconstriction. Like somatic afferent neurons involved in inflammation-induced hyperalgesia, the excitability of airway afferent neurons is not fixed but, rather, can be increased by the action of a variety of mediators ...
journal_title:Current opinion in pharmacology
pub_type: 杂志文章,评审
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