Abstract：
:Gasotransmitters fulfill important roles in cellular homeostasis having been linked to various pathologies, including inflammation and cardiovascular diseases. In addition to the known pathways mediating the actions of gasotransmitters, their effects in regulating mitochondrial function are emerging. Given that mitochondria are key organelles in energy production, formation of reactive oxygen species and apoptosis, they are important mediators in preserving health and disease. Preserving or restoring mitochondrial function by gasotransmitters may be beneficial, and mitigate pathogenetic processes. In this review we discuss the actions of gasotransmitters with focus on their role in mitochondrial function and their therapeutic potential.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Hendriks KD,Maassen H,van Dijk PR,Henning RH,van Goor H,Hillebrands JLdoi
10.1016/j.coph.2019.07.001subject
Has Abstractpub_date
2019-04-01 00:00:00pages
87-93eissn
1471-4892issn
1471-4973pii
S1471-4892(19)30017-7journal_volume
45pub_type
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