Abstract：
:During the past decade, evidence has accumulated for the involvement of purines and purine receptors in the pathogenesis and pathophysiology of asthma and chronic obstructive pulmonary diseases. In particular, the indirect bronchospasmic and inflammatory actions of purines via the activation and degranulation of mast cells has been extensively studied and reviewed. At present, interest is focused on the impact of purines on pulmonary innervation and the neuroendocrine system, and the potent interaction of the latter with many of the airway components that are essentially altered in asthma and chronic obstructive pulmonary disease. However, data related to these interactions are diverse and not always easily recognised in the literature.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Adriaensen D,Timmermans JPdoi
10.1016/j.coph.2004.01.010keywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
207-14issue
3eissn
1471-4892issn
1471-4973pii
S1471489204000591journal_volume
4pub_type
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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更新日期：2011-06-01 00:00:00
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journal_title：Current opinion in pharmacology
pub_type： 杂志文章,评审
doi：10.1016/s1471-4892(02)00174-1
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journal_title：Current opinion in pharmacology
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doi：10.1016/j.coph.2012.06.002
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journal_title：Current opinion in pharmacology
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doi：10.1016/j.coph.2012.07.006
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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journal_title：Current opinion in pharmacology
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