Abstract：
:Rhabdomyolysis is a clinical condition of potential life threatening destruction of skeletal muscle caused by diverse mechanisms including drugs and toxins. Given the fact that structurally not related compounds cause an identical phenotype pinpoints to common targets or pathways, responsible for executing rhabdomyolysis. A drop in myoplasmic ATP paralleled with sustained elevations in cytosolic Ca²⁺ concentration represents a common signature of rhabdomyolysis. Interestingly, cardiac tissue is hardly affected or only secondary, as a consequence of imbalance in electrolytes or acid-base equilibrium. This dogma is now impaired by compounds, which show up with combined toxicity in heart and skeletal muscle. In this review, cases of rhabdomyolysis with novel recently approved drugs will be explored for new target mechanisms in the light of previously described pathomechanisms.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Hohenegger Mdoi
10.1016/j.coph.2012.04.002subject
Has Abstractpub_date
2012-06-01 00:00:00pages
335-9issue
3eissn
1471-4892issn
1471-4973pii
S1471-4892(12)00052-5journal_volume
12pub_type
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