Contributions of adipocyte lipid metabolism to body fat content and implications for the treatment of obesity.

abstract：:Neutrophils are instrumental in innate immunity by mediating immediate removal of pathogens. Recent findings demonstrate that they are able to communicate with dendritic cells, which form a link between innate and adaptive immunity by stimulating long-term memory T cell responses. This communication occurs through the...

journal_title：Current opinion in pharmacology

authors： Ludwig IS,Geijtenbeek TB,van Kooyk Y

更新日期：2006-08-01 00:00:00

abstract：:Two new approaches for the treatment of osteoporosis are summarized, each having arisen out of important new discoveries in bone biology. Odanacatib (ODN) inhibits the enzyme, cathepsin K, that is essential for the resorbing activity of osteoclasts. It is effective in preventing ovariectomy-induced bone loss in precli...

journal_title：Current opinion in pharmacology

authors： Ng KW,Martin TJ

更新日期：2014-06-01 00:00:00

abstract：:Reporter-gene assays offer an alternative to biochemical assays for following signal transduction pathways from receptors at the cell surface to nuclear gene transcription in living cells. Specific reporter-gene systems are now available for the study of ligand activity at G alpha(i/o), G alpha(s) and G alpha(q) G-pro...

journal_title：Current opinion in pharmacology

authors： Hill SJ,Baker JG,Rees S

更新日期：2001-10-01 00:00:00

abstract：:CLEC-2 is a C-type lectin-like molecule that has recently been identified as a receptor on the surface of platelets. Ligand binding by CLEC-2 promotes phosphorylation of a tyrosine in the cytoplasmic domain YXXL motif of CLEC-2 by Src kinases and further downstream signalling events trigger platelet activation and agg...

journal_title：Current opinion in pharmacology

authors： O'Callaghan CA

更新日期：2009-04-01 00:00:00

abstract：:Increased understanding of gastrointestinal pathophysiology in functional bowel disorders is leading to improved focus on relevant enteric, vagal and spinal afferent nervous systems, and targets operating on these systems. These targets include receptors for tachykinins, motilin, ghrelin, corticotropin-releasing facto...

journal_title：Current opinion in pharmacology

authors： Sanger GJ,Hicks GA

更新日期：2002-12-01 00:00:00

abstract：:The repertoire of signal transduction pathways activated by dopamine in brain includes the increase of intracellular calcium. However the mechanism(s) by which dopamine activated this important second messenger system was/were unknown. Although we showed that activation of the D5 dopamine receptor increased calcium co...

journal_title：Current opinion in pharmacology

authors： Hasbi A,O'Dowd BF,George SR

更新日期：2010-02-01 00:00:00

abstract：:The inflammatory response is regulated by the production of different extracellular mediators, including lipids and extracellular nucleotides. In the extracellular environment, intermediate lipids activate specific G-protein-coupled receptors (GPCRs) in target cells and promote cell recruitment and activation. Extrace...

journal_title：Current opinion in pharmacology

authors： Alarcón-Vila C,Pizzuto M,Pelegrín P

更新日期：2019-08-01 00:00:00

abstract：:Successful cancer therapy requires the selective killing of cancer cells. Many molecular components of the pathways that lead to cell death have recently been identified and a number of these, including p53, Apaf-1, and members of the inhibitor of apoptosis protein and Bcl-2 gene families, have been found to be altere...

journal_title：Current opinion in pharmacology

authors： Bunz F

更新日期：2001-08-01 00:00:00

abstract：:Therapeutic drug monitoring (TDM) plays a vital role in implementing precision medicine in inflammatory bowel disease (IBD), and may contribute to increased effectiveness, lower rates of drug toxicity and cost savings. While expert panels advocate the use of reactive TDM for anti-tumor necrosis factor (anti-TNF) agent...

journal_title：Current opinion in pharmacology

authors： Alsoud D,Vermeire S,Verstockt B

更新日期：2020-12-01 00:00:00

abstract：:Early animal, menstrual phase and gender comparative studies inconsistently support an oestrogen-induced increase in fat oxidation during exercise. Recent advances from studies of cellular signalling and gene expression provide evidence for inter-tissue and intramuscular mechanisms that demonstrate oestrogen's promoti...

journal_title：Current opinion in pharmacology

authors： Oosthuyse T,Bosch AN

更新日期：2012-06-01 00:00:00

abstract：:Fibrosis can occur in most organs and is characterised by excessive and progressive extracellular matrix deposition and destruction of normal tissue architecture and function. In many cases treatment options are limited. Fibrotic diseases are therefore associated with high morbidity and mortality. Tissue biopsies rema...

journal_title：Current opinion in pharmacology

authors： Tatler AL

更新日期：2019-12-01 00:00:00

abstract：:Mitochondria play a key role in energy metabolism in many tissues, including skeletal muscle and liver. Inherent disorders of mitochondria such as DNA deletions cause major disruption of metabolism and can result in severe impairment or death. However, the occurrence of such disorders is extremely rare and cannot acco...

journal_title：Current opinion in pharmacology

authors： Johannsen DL,Ravussin E

更新日期：2009-12-01 00:00:00

abstract：:Human pluripotent stem cells can be differentiated into specific, relevant cell types of interest including the cells of the retina and optic nerve. These cells can then be used to study fundamental biology as well as disease modelling and subsequent screening of potential treatments. Many models of differentiation an...

journal_title：Current opinion in pharmacology

authors： Lidgerwood GE,Hewitt AW,Pébay A

更新日期：2019-10-01 00:00:00

abstract：:The second messenger, cAMP, is one of the most important regulatory signals for control of steroidogenesis. This review focuses on current knowledge about regulation of cyclic nucleotides by phosphodiesterases (PDEs) in steroidogenic tissues. The first PDE known to directly regulate steroidogenesis was PDE2, the cGMP-...

journal_title：Current opinion in pharmacology

authors： Tsai LC,Beavo JA

更新日期：2011-12-01 00:00:00

abstract：:Synthetic glucocorticoids are potent modulators of the immune system, and are clinically invaluable in the treatment of a wide variety of conditions. However, their use can be limited by harmful side effects, and their mechanisms of action remain poorly understood and controversial. It has recently been reported that ...

journal_title：Current opinion in pharmacology

authors： Clark AR,Lasa M

更新日期：2003-08-01 00:00:00

abstract：:In response to the emergence of parasite drug resistance to currently deployed antimalarials, the scientific community, in partnership with the pharmaceutical industry and public organizations, has fashioned an antimalarial drug development portfolio for the sustained development and registration of safe, effective an...

journal_title：Current opinion in pharmacology

authors： Biagini GA,O'Neill PM,Bray PG,Ward SA

更新日期：2005-10-01 00:00:00

abstract：:Leptin and adiponectin are the major adipokines secreted by fat cells. Leptin effects energy homeostasis by decreasing food intake and by acting on lipogenesis and fatty acid oxidation. Elucidation of the mechanisms of action of adiponectin (Acrp30), a hormone considered to be a major insulin-sensitizing hormone, and ...

journal_title：Current opinion in pharmacology

authors： Lafontan M,Viguerie N

更新日期：2006-12-01 00:00:00

abstract：:Toll-like receptors (TLRs) play a crucial role in host defence and inflammation. Given that a significant amount of evidence implicates TLRs in the pathogenesis of immune diseases and cancer, and their activation occurs early in the inflammatory cascade, they are attractive targets for novel therapeutic agents. Potent...

journal_title：Current opinion in pharmacology

authors： Connolly DJ,O'Neill LA

更新日期：2012-08-01 00:00:00

abstract：:An increasing number of genetic diseases are found to result from mutations that lead to retention of the affected proteins in the endoplasmic reticulum, where they are recognized as misfolded by the quality control system. Several of these conformational diseases involve mutations in G-protein-coupled receptors. Rece...

journal_title：Current opinion in pharmacology

authors： Bernier V,Bichet DG,Bouvier M

更新日期：2004-10-01 00:00:00

abstract：:Putative druggable targets to selectively enhance cardiac conduction can be considered from the level of the ion channels determining the initiation and duration of the cardiac action potential to the gap junction proteins responsible for optimal cellular electrical coupling. Nature has provided a number of inherited ...

journal_title：Current opinion in pharmacology

authors： Gomes J,Lambiase PD

更新日期：2009-04-01 00:00:00

abstract：:Reactive oxygen species play important roles in the pathophysiology of chronic heart failure secondary to chronic left ventricular hypertrophy or myocardial infarction. Reactive oxygen species influence several components of the phenotype of the failing heart, including contractile function, interstitial fibrosis, end...

journal_title：Current opinion in pharmacology

authors： Murdoch CE,Grieve DJ,Cave AC,Looi YH,Shah AM

更新日期：2006-04-01 00:00:00

abstract：:Neutrophils are key innate immune effector cells that are rapidly recruited to sites of infection and inflammation to provide early defence against invading microorganisms. This function is facilitated by the expression of Toll-like receptor (TLR) family members by neutrophils, allowing the recognition of an extensive...

journal_title：Current opinion in pharmacology

authors： Prince LR,Whyte MK,Sabroe I,Parker LC

更新日期：2011-08-01 00:00:00

abstract：:Gut microbiota has a crucial role in the maintenance of health. Increasing evidence suggests that changes or disturbances in gut microbiota may be associated with various diseases. Therefore, preclinical and clinical studies related to gut microbiota are becoming increasingly important. Germ-free animal experimentatio...

journal_title：Current opinion in pharmacology

authors： Uzbay T

更新日期：2019-12-01 00:00:00

abstract：:Angiotensin type 1 (AT1) receptors are key effector elements of the renin-angiotensin system, mediating virtually all of the classical physiological actions of angiotensin II. Pharmacological blockade of the AT1 receptor effectively lowers blood pressure in a substantial proportion of patients with hypertension, indic...

journal_title：Current opinion in pharmacology

authors： Chen D,Coffman TM

更新日期：2015-04-01 00:00:00

abstract：:It has been a few decades since Ca(2+) was identified as one of the important factors that can accelerate gastric wound repair as well as contribute to epithelial homeostasis and regulation of gastric secretions. The mechanistic basis has remained largely unexplored in vivo because it was not possible to track in real...

journal_title：Current opinion in pharmacology

authors： Aihara E,Montrose MH

更新日期：2014-12-01 00:00:00

abstract：:High-quality monoclonal antibodies (mAbs) with specificity for relevant disease molecules can now be produced in abundance. Anti-tumour necrosis factor-alpha therapies have set a new standard for symptom control in rheumatoid arthritis, and blockade of tumour necrosis factor has the potential to protect joints from st...

journal_title：Current opinion in pharmacology

authors： Taylor PC

更新日期：2003-06-01 00:00:00

abstract：:Skeletal lesions contribute substantially to morbidity and mortality in patients with cancer. Emerging treatments for metastatic bone disease have arisen from our understanding of the biology of bone metastases. Tumour cells alter the functions of bone-resorbing (osteoclasts) and bone-forming (osteoblasts) cells, prom...

journal_title：Current opinion in pharmacology

authors： Clément-Demange L,Clézardin P

更新日期：2015-06-01 00:00:00

abstract：:Introduction of biological agents for the treatment of the chronic inflammatory joint disease rheumatoid arthritis has reinvigorated research into this debilitating disease. These agents have been shown to both act on the signs and symptoms of disease, as well as retard the progression of joint destruction. However, t...

journal_title：Current opinion in pharmacology

authors： Blake SM,Swift BA

更新日期：2004-06-01 00:00:00

abstract：:The past decade has witnessed a growing interest in the trophic effects of antidepressant drugs. Antidepressants stimulate the production and signaling of plasticity-related proteins such as neurotrophins and cAMP response element binding protein, and neurotrophin signaling appears to be both sufficient and necessary ...

journal_title：Current opinion in pharmacology

authors： Castrén E

更新日期：2004-02-01 00:00:00

abstract：:Since its discovery in 1993 and subsequent development of selective antagonists, a growing number of studies support the use of serotonin 5-HT(6) receptor antagonism as a promising mechanism for treating cognitive dysfunction. Lately, several studies with structurally different compounds have shown that not only antag...

journal_title：Current opinion in pharmacology

authors： Codony X,Vela JM,Ramírez MJ

更新日期：2011-02-01 00:00:00