Abstract:
:High-quality monoclonal antibodies (mAbs) with specificity for relevant disease molecules can now be produced in abundance. Anti-tumour necrosis factor-alpha therapies have set a new standard for symptom control in rheumatoid arthritis, and blockade of tumour necrosis factor has the potential to protect joints from structural damage. Other targets for therapeutic antibodies include the cytokines interleukin (IL)-1, IL-6, IL-8, IL-15, IL-17 and IL-18. In addition, there is preliminary evidence for the clinical efficacy of both keliximab, a mAb targeting the T cell antigen CD4, and rituximab, a chimeric mAb against the B cell antigen CD20 and CTLA4-Ig, which blocks the CD28/B7 interaction. Phase III studies have yet to be undertaken for these novel biological agents, and it is unclear whether any of these agents will have true disease-modifying capabilities.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Taylor PCdoi
10.1016/s1471-4892(03)00032-8keywords:
subject
Has Abstractpub_date
2003-06-01 00:00:00pages
323-8issue
3eissn
1471-4892issn
1471-4973pii
S1471489203000328journal_volume
3pub_type
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