Abstract:
:Hepatocellular carcinoma (HCC) is the 5th most common cancer, but the 3rd leading cause of cancer death globally with approximately 700,000 fatalities annually. The severity of this cancer arises from its difficulty to detect and treat. The major etiologies of HCC are liver fibrosis or cirrhosis from chronic viral infections, as well as metabolic conditions. Since most cases arise from prior pathologies, biomarker surveillance in high-risk individuals is an essential approach for early detection and improved patient outcome. While many molecular biomarkers have been associated with HCC, there are few that have made clinical impact for this disease. Here we review some major approaches used for HCC biomarker discovery-proteomics and glycomics-and describe new methodologies being tested for biomarker development.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Black AP,Mehta ASdoi
10.1016/j.coph.2018.04.002subject
Has Abstractpub_date
2018-08-01 00:00:00pages
74-78eissn
1471-4892issn
1471-4973pii
S1471-4892(18)30005-5journal_volume
41pub_type
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