Abstract:
:Pseudomonas aeruginosa is an opportunistic pathogen that significantly contributes to morbidity and mortality in patients with cystic fibrosis. Defective mucociliary clearance associated with the absence of the functional cystic fibrosis transmembrane conductance regulator in airway epithelium plays a critical role in the initial colonization of this pathogen. P. aeruginosa, while initiating a profound inflammatory response, employs multiple mechanisms to evade immune clearance. The capacity to grow in biofilms and the selection of mutants with a mucoid phenotype are major adaptations that allow its persistence in the airways.
journal_name
Curr Opin Pharmacoljournal_title
Current opinion in pharmacologyauthors
Gómez MI,Prince Adoi
10.1016/j.coph.2006.12.005subject
Has Abstractpub_date
2007-06-01 00:00:00pages
244-51issue
3eissn
1471-4892issn
1471-4973pii
S1471-4892(07)00060-4journal_volume
7pub_type
杂志文章,评审abstract::Immunotherapies revolutionised the treatment of several disorders but show specific side-effect profiles which frequently involve psychological symptoms. Long term interferon-alpha (IFN-alpha) therapy can cause wide-ranging psychiatric side-effects from fatigue, insomnia, anxiety to full-blown depression. This treatme...
journal_title:Current opinion in pharmacology
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journal_title:Current opinion in pharmacology
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